Effect of placenta penetration during cordocentesis at mid‐pregnancy on fetal outcomes

Boupaijit, Kuanoon; Wanapirak, Chanane; Piyamongkol, Wirawit; Sirichotiyakul, Supatra; Tongsong, Theera

doi:10.1002/pd.2916

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…The potential confounders needed to be controlled or excluded, included placenta traversed, difficult procedures, twin pregnancies, gestational age, and levels of operators’ experience. Placenta traversed has been associated with adverse outcomes [20]. Gestational age certainly has an influence on the outcomes of procedures and pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Umbilical Cord Bleeding following Mid-Pregnancy Cordocentesis on Pregnancy Outcomes

Tongsong

Khumpho²,

Wanapirak³

et al. 2012

Gynecol Obstet Invest

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Objectives: To compare the adverse pregnancy outcomes among the three groups of umbilical cord bleeding following cordocentesis; a group of no bleeding (group 1), transient bleeding (group 2), and persistent bleeding (>60 s: group 3). Methods: Consecutive cases of cordocentesis were prospectively recorded and followed up. The inclusion criteria for analysis consisted of (1) singleton pregnancies; (2) gestational age of 18–22 weeks; (3) no fetal anomalies; (4) no previous invasive procedures; (5) performed by experienced operators, and (6) known pregnancy outcomes. The main outcomes were rates of fetal loss, low birth weight and preterm birth. Results: Of 2,174 procedures, 1,614 were in group 1, 509 were in group 2, and 51 were in group 3. The mean birth weight and gestational age at delivery were significantly lower in group 3 than those in groups 1 and 2. The fetal loss rate was significantly higher in group 3. Rates of low birth weight and preterm birth were significantly higher in group 3 whereas the rates in group 2 had a tendency to be higher than those in group 1. Conclusion: This study suggests that cord bleeding during cordocentesis carries a higher risk of fetal loss, low birth weight and preterm birth.

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Section: Discussionmentioning

confidence: 99%

Effect of Umbilical Cord Bleeding following Mid-Pregnancy Cordocentesis on Pregnancy Outcomes

Tongsong

Khumpho²,

Wanapirak³

et al. 2012

Gynecol Obstet Invest

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“…After 20th week of gestation, the option is percutaneous umbilical blood sampling or cordocentesis, which involves direct sampling of fetal blood from the umbilical cord. The procedure-related loss rate is about 1.0-1.5% and cordocentesis with placenta penetration had a significantly higher rate of fetal loss [54][55][56].…”

Section: Prenatal Screening and Diagnosismentioning

confidence: 98%

Down Syndrome: Clinical and Genetic Aspects, Genetic Counseling and Prenatal Screening and Diagnosis

Pavarino¹,

Biselli²,

Pinto³

et al. 2013

Down Syndrome

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“…The couples at risk are offered prenatal diagnosis, by chorionic villus sampling, amniocentesis, or cordocentesis according to their gestational age and laboratory availability. However, such invasive prenatal diagnostic procedures pose fetal loss rate, including less than 1% for chorionic villus sampling and amniocentesis and 2% for cordocentesis …”

Section: Introductionmentioning

confidence: 99%

The performance of cardio‐biparietal ratio measured by 2D ultrasound in predicting fetal hemoglobin Bart disease during midpregnancy: A pilot study

2019

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Objective: The aim of this study was to assess the performance of cardio-biparietal ratio measured by real-time two-dimensional ultrasound in predicting hemoglobin (Hb) Bart disease among fetuses at risk.Method: This prospective diagnostic study recruited pregnancies at risk for Hb Bart disease at 17 to 22 weeks' gestation. Cardio-biparietal ratio and cardiothoracic ratio were measured before cordocentesis for Hb typing. The performance of the cardiobiparietal ratio and cardiothoracic ratio for identifying affected fetuses was evaluated.Results: Among 72 fetuses at risk, 31 were diagnosed as affected by Hb Bart disease. By using a cutoff 0.45, cardio-biparietal ratio had a sensitivity of 83.9%, specificity of 92.7%, positive predictive value of 89.7%, and negative predictive value of 88.4%, whereas cardiothoracic ratio using cutoff 0.5 had a sensitivity of 94.3%, specificity of 65.1%, positive predictive value of 68.8%, and negative predictive value of 93.3%.Conclusion: Cardio-biparietal ratio is a new sonomarker to predict Hb Bart disease among fetuses at risk. This sonomarker is relatively effective and may be useful in areas of high prevalence of alpha thalassemia disease, limited number of experts in prenatal ultrasound, and difficult access to prenatal diagnosis.

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Effect of placenta penetration during cordocentesis at mid‐pregnancy on fetal outcomes

Abstract: Cordocentesis with placenta penetration carries a higher risk for fetal loss, preterm birth, and low birth weight. This information may be helpful in prenatal diagnosis counseling, and it may encourage performers to avoid placenta penetration, if possible.

Cited by 10 publications

References 13 publications

Effect of Umbilical Cord Bleeding following Mid-Pregnancy Cordocentesis on Pregnancy Outcomes

Effect of Umbilical Cord Bleeding following Mid-Pregnancy Cordocentesis on Pregnancy Outcomes

Down Syndrome: Clinical and Genetic Aspects, Genetic Counseling and Prenatal Screening and Diagnosis

The performance of cardio‐biparietal ratio measured by 2D ultrasound in predicting fetal hemoglobin Bart disease during midpregnancy: A pilot study

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