Effect of plant extracts on Alzheimer’s disease: An insight into therapeutic avenues

Obulesu, Magisetty; Rao, Dowlathabad Muralidhara

doi:10.4103/0976-3147.80102

Cited by 73 publications

(47 citation statements)

References 74 publications

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“…This opens a substantial therapeutic strategy for the treatment of AD by inhibiting YAP/Bax pathway [123]. A few plant extracts, carotenoids, antioxidants and Chinese traditional medicines such as SuHeXiang Wan [124] have shown neuroprotective effects but they need potential further studies to validate the neuroprotective effects [125,126]. Recently, it has been shown that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride (KHG26377) has a protective role against the beta-amyloid (Ab 25-35 )-induced primary cortical neuronal cell neurotoxicity [127].…”

Section: Resultsmentioning

confidence: 98%

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

2014

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Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex etiology. Apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as Bcl2, Bax, caspases, amyloid beta, tumor necrosis factor-α, amyloid precursor protein intracellular C-terminal domain, reactive oxygen species, perturbation of enzymes leads to deleterious neurodegenerative disorders like AD. There are diverse pathways that provoke manifold events in mitochondria and endoplasmic reticulum (ER) to execute the process of cell death. This review summarizes the crucial apoptotic mechanisms occurring in both mitochondria and ER. It gives substantial summary of the diverse mechanisms studied in vivo and in vitro. A brief account on neuroprotection of several bioactive components, flavonoids and antioxidants of plants against apoptotic events of both mitochondria and ER in both in vitro and in vivo has been discussed. In light of this, the burgeoning need to develop animal models to study the efficacy of various therapeutic effects has been accentuated.

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Section: Resultsmentioning

confidence: 98%

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

2014

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“…The studies have shown that regular consumption of lemon balm infusions by people suffering from Alzheimer's disease positively influences their cognitive functions and relieves the symptoms of senile dementia. What is more, lemon balm may lower the level of cholesterol in blood and therefore prevent atherosclerosis [22,23].…”

Section: Lemon Balm (Melissa Officinalis)mentioning

confidence: 99%

Health Properties of Selected Herbal Plants

Kozák

Sobczak

Żukiewicz-Sobczak³

2016

hpc

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“…Las hojas, cuyo consumo incluso en altas cantidades carecen de toxicidad, se han encontrado que poseen antioxidantes como las vitamina C y E, mejoran la memoria por medios nootropicos; se sospecha que podría ser utilizado para el tratamiento del Alzheimer según la investigación realizada por Obelesu M y col (6).…”

Section: Introduccionunclassified

Moringa oleifera acute effect on dexamethasone-induced hyperglycemia in Wistar rats

Santacruz¹,

Barreto

Malvetti

et al. 2016

An. Fac. Cienc. Méd. (Asunción)

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RESUMEN INTRODUCCIÓN:Se han atribuido muchos efectos beneficiosos a la moringa oleífera en varias publicaciones siendo de gran interés su efecto hipoglicemiante por disminución de la absorción intestinal de glucosa, aunque no está definido si su eficacia hipoglicemiante sería igual o mayor a algún hipoglicemiante oral conocido. El objetivo del presente estudio fue determinar el efecto agudo de moringa oleífera en hiperglucemia inducida por dexametasona en ratas Wistar hembras, así como comparar su efecto hipoglicemiante con la metformina. MATERIALES Y MÉTODOS: Estudio experimental, tres grupos de cinco ratas Wistar hembras, con peso de 188 ± 11 gramos. Se realizó la medición de la glucemia basal con glucómetro, después de 12 horas de ayuno, la inicial al principio del experimento, luego fueron tratadas con dexametasona 10 mg/kg/día, subcutánea, durante 10 días y se tomó la glicemia post dexametasona . Los días 11 a 14, recibieron el grupo 1 (suero fisiológico), grupo 2 (moringa oleífera 300 mg/kg/día) y grupo 3 (metformina 14,28 mg/kp/día), por sonda oro gástrica, el día 15 se tomó la glucemia post tratamiento. Se analizó el promedio, desviación estándar y la correlación mediante la prueba la prueba T de Student, se consideró P < a 0,05 como significativa. RESULTADOS: Grupo 1 (control): glucemia inicial (117 ± 21 mg/dl), post-dexametasona (445 ± 260 mg/dl) y post tratamiento (222 ± 5 mg/dL), Grupo 2 (moringa oleífera): glucemia inicial (95±27 mg/dl), post dexametasona (413 ± 184 mg/dl) y post tratamiento (102 ± 18 mg/dl) y del Grupo 3 (metformina): glucemia inicial (110 ± 5 mg/dl), post-dexametasona (470 ± 146 mg/dl) y post tratamiento (88 ± 11 mg/dL). La glucemia pos tratamiento mostró diferencias entre el grupo 1 y 2 (p < 0,0001), entre el grupo 1 y 3 (p < 0,0001) no hallándose diferencias entre los grupos moringa oleífera y metformina (p = 0,1). DISCUSIÓN: la moringa oleífera disminuye en forma aguda la hiperglucemia inducida por dexametasona en ratas hembras Wistar, con la misma eficacia que la metformina Palabras clave: moringa oleífera, hiperglicemia, ratas Wistar, mefformina. ABSTRACTSanta Cruz F et al  Efecto agudo de moringa oleífera sobre la hiperglucemia inducida por ... An. Fac. Cienc. Méd. (Asunción) / Vol. 48 -Nº 1, 2015 42INTRODUCTION: It has been attributed many beneficial effects of moringa oleífera in various publications to be of great interest for its hypoglycemic effect due to decreased intestinal absorption of glucose; although it is not defined if his hypoglycemic efficacy would be equal to or greater than any known oral hypoglycemic agent. The objective of this study was to determine the acute effect of moringa oleífera on hyperclycemia induced by dexamethasone in female Wistar rats and compare its hypoglycemic effect with metformin. MATERIALS AND METHODS: Experimental study, wiht 3 groups of 5 female Wistar rats, weighing 188 ± 11 grams. Measuring the basal blood glucose meter was performed after 12 hours of fasting, the initial glycemia at the beginning of the experiment and were then ...

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Effect of plant extracts on Alzheimer’s disease: An insight into therapeutic avenues

Cited by 73 publications

References 74 publications

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

Health Properties of Selected Herbal Plants

Moringa oleifera acute effect on dexamethasone-induced hyperglycemia in Wistar rats

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