Effect of plasma-derived extracellular vesicles on angiogenesis and the ensuing proliferative diabetic retinopathy through a miR-30b-dependent mechanism

Wang, Ping; Li, Chengqian; Deng, Yujie; Yu, Qing; Meng, Xuxia; Jiang, Tao; Wang, Qing; Fu, Yudong

doi:10.1186/s13098-022-00937-3

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Another study explored the impact of plasma-derived EVs on angiogenesis and the progression of proliferative diabetic retinopathy (PDR), with a focus on the role of microRNA-30b. This research suggests that the mechanisms influenced by plasma-derived EVs may regulate angiogenesis in PDR via a mechanism dependent on miR-30b [ 150 ].…”

Section: Cts-evs In Physiology and Pathologymentioning

confidence: 99%

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Amin,

Massoumi,

Tewari

et al. 2024

IJMS

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Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal in mediating intercellular communication due to their ability to selectively transfer biomolecules to specific cell types. EVs, composed of proteins, nucleic acids, and lipids, are taken up by cells to affect a variety of signaling cascades. Research in the field has primarily focused on stem cell-derived EVs, with a particular focus on mesenchymal stem cells, for their potential therapeutic benefits. Recently, tissue-specific EVs or cell type-specific extracellular vesicles (CTS-EVs), have garnered attention for their unique biogenesis and molecular composition because they enable highly targeted cell-specific communication. Various studies have outlined the roles that CTS-EVs play in the signaling for physiological function and the maintenance of homeostasis, including immune modulation, tissue regeneration, and organ development. These properties are also exploited for disease propagation, such as in cancer, neurological disorders, infectious diseases, autoimmune conditions, and more. The insights gained from analyzing CTS-EVs in different biological roles not only enhance our understanding of intercellular signaling and disease pathogenesis but also open new avenues for innovative diagnostic biomarkers and therapeutic targets for a wide spectrum of medical conditions. This review comprehensively outlines the current understanding of CTS-EV origins, function within normal physiology, and implications in diseased states.

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Section: Cts-evs In Physiology and Pathologymentioning

confidence: 99%

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Amin,

Massoumi,

Tewari

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…This transfer activates S1P1/AKT/VEGFR2 pathway, exacerbating abnormal angiogenesis 59 . Additionally, the increased tumor necrosis factor-α-induced protein 8 (TNFAIP8) and miR-30b in plasma EVs have been revealed to promote proliferation in human retinal microvascular endothelial cells 60 , 61 , making them crucial mediators of angiogenesis. Recent research has also discovered low levels of lncRNA PPT2-EGFL8 and elevated miR-423-5p in plasma EVs derived from PDR patients.…”

Section: Evs In Dr Pathology and Diagnosismentioning

confidence: 99%

Emerging role of extracellular vesicles in diabetic retinopathy

Zhu,

Huang,

Sun

et al. 2024

Theranostics

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Diabetic retinopathy (DR), a complex complication of diabetes mellitus (DM), is a leading cause of adult blindness. Hyperglycemia triggers DR, resulting in microvascular damage, glial apoptosis, and neuronal degeneration. Inflammation and oxidative stress play crucial roles during this process. Current clinical treatments for DR primarily target the advanced retinal disorder but offer limited benefits with inevitable side effects. Extracellular vesicles (EVs) exhibit unique morphological features, contents, and biological properties and can be found in cell culture supernatants, various body fluids, and tissues. In DR, EVs with specific cargo composition would induce the reaction of receptor cell once internalized, mediating cellular communication and disease progression. Increasing evidence indicates that monitoring changes in EV quantity and content in DR can aid in disease diagnosis and prognosis. Furthermore, extensive research is investigating the potential of these nanoparticles as effective therapeutic agents in preclinical models of DR. This review explores the current understanding of the pathological effects of EVs in DR development, discusses their potential as biomarkers and therapeutic strategies, and paves the way for further research and therapeutic advancements.

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“…Wang et al [ 157 ] also found that miR-30b was upregulated and SIRT1 was downregulated in the retina of diabetic mice, indicating a regulatory relationship between miR-30b and SIRT1. Inhibiting miR-30b led to an increase in SIRT1 expression, thereby reducing angiogenesis in retinal microvascular endothelial cells.…”

Section: Micrornas Participate In Dr Development By Different Mechanismsmentioning

confidence: 99%

Advances in Research Related to MicroRNA for Diabetic Retinopathy

Luo,

2024

Journal of Diabetes Research

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Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia, blood pressure, and lipid control, which includes laser photocoagulation, glucocorticoids, vitrectomy, and antivascular endothelial growth factor (anti-VEGF) medications. Despite the clinical efficacy of the aforementioned therapies, none of them can entirely shorten the clinical course of DR or reverse retinopathy. MicroRNAs (miRNAs) are vital regulators of gene expression and participate in cell growth, differentiation, development, and apoptosis. MicroRNAs have been shown to play a significant role in DR, particularly in the molecular mechanisms of inflammation, oxidative stress, and neurodegeneration. The aim of this review is to systematically summarize the signaling pathways and molecular mechanisms of miRNAs involved in the occurrence and development of DR, mainly from the pathogenesis of oxidative stress, inflammation, and neovascularization. Meanwhile, this article also discusses the research progress and application of miRNA-specific therapies for DR.

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Effect of plasma-derived extracellular vesicles on angiogenesis and the ensuing proliferative diabetic retinopathy through a miR-30b-dependent mechanism

Cited by 8 publications

References 28 publications

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Emerging role of extracellular vesicles in diabetic retinopathy

Advances in Research Related to MicroRNA for Diabetic Retinopathy

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