Effect of plasma exchange on colchicine elimination in overdose – a case report

Colchicine poisoning: Case report of three homicides in a family

“…Clinical reports support the effectiveness of Extracorporeal Membrane Oxygenation (ECMO) for treating colchicine-induced cardiogenic shock [ 13 ]. Additionally, plasma exchange and blood purification interventions may improve patient outcomes [ 14 , 15 ].…”

Colchicine: the good, the bad, the ugly and how to minimize the risks

“…The rationale for plasma exchange is that colchicine is ≈40–50% protein bound at therapeutic doses. The data are conflicting as to the benefit, with a case report of plasma exchange revealing removal of only 0.01% of the ingested dose, an amount that is unlikely to influence clinical outcome [ 76 ], while other reports have suggested potential benefit [ 72 ]. Haemodialysis is indicated to support significant renal impairment rather than as a mechanism for the removal of colchicine.…”

Progress in the management of acute colchicine poisoning in adults

“…The therapeutic effects of plasma exchange (PE) [ 39 , 40 ] and continuous veno-venous hemofiltration (CVVHDF) [ 38 ] were uncertain and need further clinical verification. Matthias et al reported that plasma exchange did not significantly remove colchicine from the whole body of the poisoned patient [ 40 ]. The probable reason for the failure of plasma exchange is the redistribution of colchicine from plasma to tissue compartments [ 40 ].…”

“…Matthias et al reported that plasma exchange did not significantly remove colchicine from the whole body of the poisoned patient [ 40 ]. The probable reason for the failure of plasma exchange is the redistribution of colchicine from plasma to tissue compartments [ 40 ]. Notably, PE could not only remove metabolic wastes but also improve the coagulation function by replenishing coagulation factors and fibrinolytic proteins.…”