Effect of plasticization on heparin release from biodegradable matrices

Tan, Lay Poh; Venkatraman, Subbu S.; Sung, P.F.; Wang, X.T.

doi:10.1016/j.ijpharm.2004.06.022

Cited by 50 publications

(30 citation statements)

References 15 publications

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“…Being biodegradable and biocompatible, PLGA is widely used for delivery of PTX and other drugs coated on stents [1,[4][5][6]. To compromise the brittle mechanical properties of PLGA, PEG of low glass transition temperature was often added as a plastizer to the PLGA matrix [6,7]. The PEG addition also resulted in accelerated or decelerated drug release in a controlled manner [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…To compromise the brittle mechanical properties of PLGA, PEG of low glass transition temperature was often added as a plastizer to the PLGA matrix [6,7]. The PEG addition also resulted in accelerated or decelerated drug release in a controlled manner [7][8][9][10]. For instance, adding 2% PEG to PLGA microparticles increased the in vitro release rate of PTX, while higher portion of PEG slowed down the PTX release [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Kang¹,

Robinson²,

Park³

et al. 2007

Journal of Controlled Release

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Mechanisms underlying the release of paclitaxel (PTX) from poly(ethylene glycol)/poly(lactic-coglycolic acid) (PEG/PLGA) blends were investigated by coherent anti-Stokes Raman scattering (CARS) microscopy. PLGA, PEG, and PTX were selectively imaged by using the resonant CARS signal from the CH 3 , CH 2 , and aromatic CH stretch vibrations, respectively. Phase segregation was observed in PLGA films containing 10 to 40 wt.% PEG in the absence of PTX loading. The PEG phase existed in the form of crystalline fibers in the (8:2, weight ratio) and (7:3) PLGA/PEG films. CARS observation indicated that PTX preferentially partitioned into the PEG domains in the (9:1) and (8:2) PLGA/PTX films, but exhibited a uniform mixing with both PLGA and PEG in the (7:3) PLGA/PEG film. The solid dispersion of PTX into PEG domains was attributed to a strong interaction between PTX and PEG, supported by the disappearance of PEG crystallization in the PTX-loaded PLGA/PEG film evidenced through X-ray diffraction analysis. PTX release was induced by exposing the film to an aqueous solution and monitored in real time by CARS and two-photon fluorescence microscopy. Fast dissolution of both PEG and PTX was observed at the film surface. Upon infiltration of water into the film, the PEG domains rearranged into ring structures enriched by both PTX and PEG. The CARS data provided a visual evidence explaining the accelerated burst release followed by more sustained release of PTX from the PLGA/PEG films as measured by HPLC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Kang¹,

Robinson²,

Park³

et al. 2007

Journal of Controlled Release

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show abstract

“…The incorporation of PEG 400 has been reported to decrease the drug initial burst, possibly by its plasticizing effect on the PLGA matrix system [47]. This effect was recently illustrated by Ibrahim et al, who developed an optimized ISG formulation of meloxicam and studied the initial burst and cumulative release of the ISG system after incorporation of 10−30 % PEG 400 along with PLGA/NMP polymeric solvent [31].…”

Section: Addition Of Plasticizers or Surfactantsmentioning

confidence: 95%

Preparation of Parenteral in situ Gel Formulation Based on smart PLGA polymer: Concepts to Decrease Initial Drug Burst and extend drug release

Ahmed¹,

Hussain²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…In the homopolymer it decreased the burst-effect and accelerated the drug release in the phase controlled by diffusion, in copolymer the plasticizer did not exert a significant effect on the kinetics of release. The differences were explained by the influence of plasticizer on polymer hydrophilicity and crystallinity (Tan et al, 2004).…”

Section: Drug Release From Plasticized Polyestersmentioning

confidence: 99%