Effect of platelet-rich and platelet-poor plasma on peri-implant innervation in dog mandibles

Song, Dandan; Huang, Yan; Dessel, Jeroen Van; Shujaat, Sohaib; Orhan, Kaan; Vangansewinkel, Tim; Eynde, Kathleen Van den; Lambrichts, Ivo; Roskams, Tania; Politis, Constantinus; Jacobs, Reinhilde

doi:10.1186/s40729-019-0193-3

Cited by 10 publications

(12 citation statements)

References 37 publications

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“…Following crown preparation and attachment, each implant was followed-up for a period of at least 1 months. The surgical procedure has been explained in a prior publication [ 31 , 32 ]. Thereafter, all animals were euthanized using an overdose of xylazine hydrochloride (intravenous injection) and immediate perfusion of 4% paraformaldehyde and 0.0125% glutaraldehyde in 0.1 M phosphate buffer (pH 7.4).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic accuracy of CBCT versus intraoral imaging for assessment of peri‐implant bone defects

et al. 2021

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Background Early detection of marginal bone loss is vital for treatment planning and prognosis of teeth and implant. This study was conducted to assess diagnostic accuracy of CBCT compared to intra-oral (IO) radiography for detection, classification, and measurement of peri-implant bone defects in an animal model. Methods Fifty-four mandible blocks with implants were harvested from nine male health adult beagle dogs with acquisition of IO, CBCT and micro-CT images from all samples. Peri-implant bone defects from 16 samples were diagnosed using micro-CT and classified into 3 defect categories: dehiscence (n = 5), infrabony defect (n = 3) and crater-like defect (n = 8). Following training and calibration of the observers, they asked to detect location (mesial, distal, buccal, lingual) and shape of the defect (dehiscence, horizontal defect, vertical defect, carter-like defect) utilizing both IO and CBCT images. Both observers assessed defect depth and width on IO, CBCT and micro-CT images at each side of peri-implant bone defect via CT-analyzer software. Data were analyzed using SPSS software and a p value of < 0.05 was considered as statistically significant. Results Overall, there was a high diagnostic accuracy for detection of bone defects with CBCT images (sensitivity: 100%/100%), while IO images showed a reduction in accuracy (sensitivity: 69%/63%). Similarly, diagnostic accuracy for defect classification was significantly higher for CBCT, whereas IO images were unable to correctly identify vestibular dehiscence, with incorrect assessment of half of the infrabony defects. For accuracy of measuring defect depth and width, a higher correlation was observed between CBCT and gold standard micro-CT (r = 0.91, 95% CI 0.86–0.94), whereas a lower correlation was seen for IO images (r = 0.82, 95% CI 0.67–0.91). Conclusions The diagnostic accuracy and reliability of CBCT was found to be superior to IO imaging for the detection, classification, and measurement of peri-implant bone defects. The application of CBCT adds substantial information related to the peri-implant bone defect diagnosis and decision-making which cannot be achieved with conventional IO imaging.

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Section: Methodsmentioning

confidence: 99%

Diagnostic accuracy of CBCT versus intraoral imaging for assessment of peri‐implant bone defects

et al. 2021

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“…Following crown preparation and attachment, each implant was followed-up for a period of at least 1 months. The surgical procedure has been explained in a prior publication (27,28). Thereafter, all animals were euthanized using an overdose of xylazine hydrochloride (intravenous injection) and immediate perfusion of 4% paraformaldehyde and 0.0125% glutaraldehyde in 0.1 M phosphate buffer (pH 7.4).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic Accuracy of CBCT Versus Intraoral Imaging for Assessment of Peri‐implant Bone Defects

Song

Shujaat

Vasconcelos

et al. 2021

Preprint

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Background: Early detection of marginal bone loss is vital for treatment planning and prognosis of teeth and implant. This study was conducted to assess diagnostic accuracy of CBCT compared to intra-oral (IO) radiography for detection, classification and measurement of peri-implant bone defects in an animal model.Methods: Fifty-four mandible blocks with implants were harvested from nine male health adult beagle dogs with acquisition of IO, CBCT and micro-CT images from all samples. Peri-implant bone defects from 16 samples were diagnosed using micro-CT and classified into 3 defect categories: dehiscence (n = 5), infrabony defect (n = 3) and crater-like defect (n = 8). Following training and calibration of the observers, they asked to detect location (mesial, distal, buccal, lingual) and shape of the defect (dehiscence, horizontal defect, vertical defect, carter-like defect) utilizing both IO and CBCT images. Both observers assessed defect depth and width on IO, CBCT and micro-CT images at each side of peri-implant bone defect via CT-analyzer software. Data were analyzed using SPSS software and a p value of < 0.05 was considered as statistically significant. Results: Overall, there was a high diagnostic accuracy for detection of bone defects with CBCT images (sensitivity: 100%/100%), while IO images showed a reduction in accuracy (sensitivity: 69%/63%). Similarly, diagnostic accuracy for defect classification was significantly higher for CBCT, whereas IO images were unable to correctly identify vestibular dehiscence, with incorrect assessment of half of the infrabony defects. For accuracy of measuring defect depth and width, a higher correlation was observed between CBCT and gold standard micro-CT (r = 0.91, 95% CI: 0.86-0.94), whereas a lower correlation was seen for IO images (r = 0.82, 95%CI: 0.67-0.91).Conclusions: The diagnostic accuracy and reliability of CBCT was found to be superior to IO imaging for the detection, classification and measurement of peri-implant bone defects. The application of CBCT adds substantial information related to the peri-implant bone defect diagnosis and decision-making which cannot be achieved with conventional IO imaging.

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“…All of the 22 selected articles were retrospective in design and focused on the oral sensory function or peri-implant innervation following dental implant treatment. Fourteen articles performed psychophysical assessment of the active or passive tactile function, five articles 4,[20][21][22][23] performed histological analysis for assessing myelinated nerve fibres within the peri-implant tissue, and three articles [24][25][26] assessed cortical plasticity through neurophysiological evaluation.…”

Section: Study Characteristicsmentioning

confidence: 99%

Osseoperception following dental implant treatment: A systematic review

Song

Shujaat

Politis

et al. 2022

J of Oral Rehabilitation

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Objectives Osseoperception is defined as the ability to perceive tactile sensation via mechanoreception in the peri‐implant environment. The objective was to systematically review the available literature on the osseoperception phenomenon following dental implant placement and to explore potential factors which might improve the perception capacity. Material and methods A literature search was performed using PubMed, Cochrane, Embase, and Web of Science databases up to June 2021. Both human and animal studies assessing sensory capacity or innervation following implant placement were included in this review. Two reviewers independently performed the study selection, data extraction and quality assessment of the included studies. The methodological quality of the included papers was assessed using Cochrane risk of bias for human studies and SYRCLE’s risk of bias tool for animal studies. Results The electronic search of databases yielded 1667 results. Following removal of duplicates, title and abstract screening and full‐text reading, 22 publications were eligible to be included in the review. Psychophysical evidence from 14 studies indicated a lower tactile function of implants, where active and passive threshold levels were found to be 5 and 50 times higher for implants compared to natural teeth, respectively. The neurophysiological evidence from three studies indicated cortical plasticity following dental implant placement, measured via trigeminal nerve evoked potentials and functional magnetic resonance imaging. Histological evidence from five studies demonstrated the presence of myelinated nerve fibres in the peri‐implant tissues. Additionally, immediate implant placement and loading showed beneficial effect on peri‐implant tissue (re)innervation; however, no other biological or physiological factors could be identified influencing osseoperception. Conclusions The reported evidence supported the existence of so‐called osseoperception phenomenon for restoring the sensory feedback pathway following oral implant rehabilitation. Further studies are required to identify factors that might further assist physiological integration of the oral implants in the human body as such to approach natural oral function.

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Effect of platelet-rich and platelet-poor plasma on peri-implant innervation in dog mandibles

Cited by 10 publications

References 37 publications

Diagnostic accuracy of CBCT versus intraoral imaging for assessment of peri‐implant bone defects

Diagnostic accuracy of CBCT versus intraoral imaging for assessment of peri‐implant bone defects

Diagnostic Accuracy of CBCT Versus Intraoral Imaging for Assessment of Peri‐implant Bone Defects

Osseoperception following dental implant treatment: A systematic review

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