Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid

Demirel, Esra; Yıldız, Kadri; Çadırcı, Kenan; Aygün, Hayati; Şenocak, Eyüp; Gündoğdu, Betül

doi:10.1016/j.aott.2018.07.005

Cited by 9 publications

(10 citation statements)

References 34 publications

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“…Therefore, studies to prevent epidural fibrosis formation in recent years have gained importance. [ 3 , 9 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 18 ] Cytokines released into the environment in epidural fibrosis such as interleukin (IL)-6, IL-8, transforming growth factor beta (TGF-β), and tumor necrosis factor alpha (TNF-α) induce the pathological process by affecting the fibroblasts and, thereby, leading to the formation of granulation tissue in the hematoma in the surgical area. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 15 , 22 ] Therefore, researchers have also examined the effects of fibroblast proliferation and wound maturation on epidural fibrosis development. In previous studies, hyaluronic acid-based gels,[ 6 ] platelet-rich fibrin, and ADCON-L® gel[ 3 ] were used to create an anti-fibrotic mechanical barrier. Although the methods that create a mechanical barrier show different efficacy, they significantly reduce the development of epidural fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 , 2 ] Epidural fibrosis develops as a result of the exaggerated healing tissue in this area, causing adhesions in the dura mater and nerve roots, and is one of the most important causes of failed back surgery syndrome caused by recurrent pain after surgery. [ 3 , 4 ] Revision surgeries performed due to recurrent pain after surgery may cause complications such as epidural bleeding, nerve root damage and dural lacerations, and worsen the clinical outcome. Therefore, the number of studies investigating the cellular mechanisms of epidural fibrosis and preventing epidural fibrosis after surgery has increased in recent years.…”

Section: Introductionmentioning

confidence: 99%

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Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model

et al. 2021

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Objectives This study aims to investigate the effect of radial extracorporeal shock wave therapy (rESWT) treatment in the prevention of epidural fibrosis after laminectomy in rats. Materials and methods Eighteen 16-month-old male Sprague-Dawley rats weighing 300 g were used in this experimental study between November 2019 and February 2020. The rats were randomly divided into two groups as the control group (L3-L4 total laminectomy without any treatment) and the study group (L3-L4 total laminectomy plus rESWT). The rats were sacrificed at the postoperative sixth week and the lumbar spine was excised en bloc, fixed, and decalcified. Sections were stained with hematoxylin-eosin to evaluate epidural fibrosis, acute inflammation, chronic inflammation, and vascular proliferation. Results The median value and standard deviations were obtained based on histological examinations. Accordingly, epidural fibrosis decreased significantly in the study group compared to the control group. There was no statistically significant difference between the groups in terms of acute and chronic inflammation response and vascular proliferation. Conclusion The rESWT application immediately after surgery is effective in preventing epidural fibrosis after laminectomy in rats.

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“…Therefore, studies to prevent epidural fibrosis formation in recent years have gained importance. [ 3 , 9 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model

et al. 2021

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“…Platelet-rich fibrin (PRF), acting as a barrier due to its membranous structure, not only controls fibroblast migration to the wound area but also reduces adhesion by controlling collagen synthesis. Demirel compared the effects of Adcon-L and PRF on EF using 28 Sprague-dawley rats and showed that the PRF group developed lower EF than the Adcon gel group [29].…”

Section: Discussionmentioning

confidence: 99%

The histopathological effects of reabsorbable polyethylene glycol hydrogel (Coseal) on epidural fibrosis in an experimental postlaminectomy model in rats

et al. 2021

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Background: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal®) on epidural fibrosis (EF) following laminectomy in rats.Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal®, Group 3) was squeezed over the dura mater, and the wound was closed. A histopathological examination was undertaken to evaluate arachnoidal invasion and EF. Results:The results of EF in the Group 2 and Group 3 were significantly lower compared to the Group 1 (p = 0.023 and p = 0.002, respectively). No statistically significant difference was found between the Group 2 and Group 3 in terms of EF (p = 0.957). There was also no statistically significant difference between the mean arachnoidal invasion of the three groups (p > 0.171). However, the rate of arachnoidal invasion was the lowest in the Group 3. Conclusion:Intraoperative Coseal®, a polyethylene glycol polymer, tends to reduce the risk of epidural fibrosis, although this is not statistically significant.

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Evaluation of the osteoconductive properties of scaffold containing platete-enriched-fibrin (PRF) with three calcium phosphate (TCP) in the alveolar socket repair after tooth extraction: An animal study

et al. 2023

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Bone regeneration can be accomplished through osteogenesis, osteoinduction, and osteoconduction mechanisms. This study aimed to investigate the properties of the PRF scaffold with tricalcium phosphate nanoparticles in socket preservation in an animal model. Fabrication of PRF performed. In this experimental study, 18 rats were divided into three negative control, PRF, and PRF/TCP groups. The mechanical and chemical tests including swelling rate, degradation time, and MTT tests were applied to the scaffolds. In each animal, the first maxillary right molar was extracted, and extraction sites of test groups were filled with a resorbable biocompatible biomaterial in situ hardening bone substitute. After 2 and 4 weeks all animals were sacrificed and examined histopathologically and with qRT-PCR. Histological results showed TCP in combination with PRF accelerates bone regeneration with the highest amount of lamellar bone and collagen formation compared to the control and PRF alone. Mechanical and chemical tests on the scaffolds showed the addition of TCP to the PRF scaffold decreases the swelling rate and increases the degradation time. qRT-PCR showed expression of osteogenic genes increased significantly ( p < 0.05) in PRF/TCP and PRF, respectively. In conclusion, the gelatin hydrogel containing PRF/TCP scaffold led to more bone formation after tooth extraction. Therefore, the injectable PRF\TCP hydrogel is a promising candidate for bone repair and regeneration.

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Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid

Abstract: We concluded that PRF contributed to hemostasis and prevented epidural fibrosis.

Cited by 9 publications

References 34 publications

Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model

Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model

The histopathological effects of reabsorbable polyethylene glycol hydrogel (Coseal) on epidural fibrosis in an experimental postlaminectomy model in rats

Evaluation of the osteoconductive properties of scaffold containing platete-enriched-fibrin (PRF) with three calcium phosphate (TCP) in the alveolar socket repair after tooth extraction: An animal study

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