Effect of platelet-rich fibrin on alveolar ridge preservation

Pan, Jiayu; Xu, Quifang; Hou, Jingya; Wu, Yun; Liu, Yanqing; Li, Rong; Pan, Yaping; Zhang, Dongmei

doi:10.1016/j.adaj.2019.04.025

Cited by 48 publications

(26 citation statements)

References 41 publications

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“…The use of PRF (with or without additional bone grafting material, such as deproteinized bovine bone mineral, DBBM) for ridge preservation has been reported previously. However, its efficacy has been evaluated with heterogeneous approaches, and results are inconsistent (Castro et al, ; Pan et al, ; Temmerman et al, ). Interestingly, it was observed that some patients have smaller and/or shorter PRF membranes than others (Mazzocca et al, ).…”

Section: Introductionmentioning

confidence: 99%

Implant stability in patients treated with platelet‐rich fibrin and bovine bone substitute for alveolar ridge preservation is associated with peripheral blood cells and coagulation factors

Brouwers¹,

Vorm

Buis

et al. 2019

Clinical & Exp Dental Res

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Aims The aim of the present study was to assess the association between dental implant stability and peripheral blood cell composition and levels of coagulation factors in patients treated with alveolar ridge preservation with platelet‐rich fibrin (PRF) and bovine bone substitute. Materials and methods Fifty patients were included between 2015 and 2017. PRF was prepared from autologous blood, in which blood cells and coagulation factor levels were measured. PRF and bovine bone were placed in the socket, followed by closure with PRF membrane. Implants were placed 14 (±2.5) weeks postextraction. The implant stability quotient was measured at t = 0, t = 10 days, t = 7 weeks, and t = 17 weeks by resonance frequency analysis. Results Erythrocyte count was inversely associated with PRF membrane length, but not with implant stability. Conversely, platelet count did not correlate with membrane size but inversely correlated with implant stability at 7 and 17 weeks. In addition, implant stability was directly correlated with levels FXIII (t = 0, p < .01), active von Willebrand factor (VWF; t = 0 and 7 weeks, p < .05), and total VWF (t = 7 weeks, p = .012). Conclusion Implant stability following alveolar ridge preservation with PRF and bovine bone substitute is associated with circulating blood cells and coagulation factors. In particular, fibrin structure, VWF, and FXIII may be important modulators of implant stability.

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Section: Introductionmentioning

confidence: 99%

Implant stability in patients treated with platelet‐rich fibrin and bovine bone substitute for alveolar ridge preservation is associated with peripheral blood cells and coagulation factors

Brouwers¹,

Vorm

Buis

et al. 2019

Clinical & Exp Dental Res

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“…The findings of a systematic review and meta-analysis suggested that PRF use may improve alveolar ridge preservation and bone fill in extraction sockets. However, the current evidence is insufficient to conclude the benefit of PRF in bone regeneration 23 . Another meta-analysis of twelve studies reveals that PRF addition to open flap debridement improves soft and hard tissue healing as determined by the amount of gingival margin change and bone fill in intrabony defects 24 .…”

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confidence: 95%

Autologous platelet-rich fibrin stimulates canine periodontal regeneration

Kornsuthisopon

Pirarat

Osathanon

et al. 2020

Sci Rep

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Platelet-rich fibrin (PRF) provides a scaffold for cell migration and growth factors for promoting wound healing and tissue regeneration. Here, we report using PRF in periodontal healing after open flap debridement (OFD) in canine periodontitis. A split-mouth design was performed in twenty dogs. Forty periodontitis surgical sites were randomly categorized into 2 groups; OFD alone and OFD with PRF treatment. Clinical parameters of periodontal pocket depth, gingival index, and the cemento-enamel junction-alveolar bone levels/root length ratio were improved in the OFD + PRF group. The OFD + pRf group also demonstrated a dramatically decreased inflammatory score compared with the OFD group. Collagen accumulation was improved in the OFD + PRF group at later time points compared with baseline. PRF application also significantly reduced inflammatory cytokine expression (TNFA and IL1B), and promoted the expression of collagen production-related genes (COL1A1, COL3A1, and TIMP1) and growth factors (PDGFB, TGFB1, and VEGFA). These findings suggest that PRF combined with OFD provides a new strategy to enhance the overall improvement of canine periodontitis treatment outcomes, especially in terms of inflammation and soft tissue healing. Therefore, PRF use in treating periodontitis could play an important role as a regenerative material to improve canine periodontitis treatment.

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“…The results of the clinical measurements of the closing of the wound by secondary intention with a periodontal probe 16,24,32 are similar to those demonstrated in our report, with a clear distinction in the type of teeth measured, such as premolars, 15,16,28 incisors, canines, 10,14,24 or lower third molars. 32 Recent systematic reviews 23,33,34 are inconclusive as to the effect of PRF on soft tissue healing. These results may be due to both teeth having been treated surgically in a similar way, after an atraumatic technique and preservation of the gingiva with sutures, preventing their Measurement with periapical radiographs to evaluate changes of the alveolar bone after tooth extraction has been previously used and validated by several studies.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 Recent systematic reviews have reported that L-PRF does not offer greater benefits in bone formation compared with a blood clot, 12,20 and others have been inconclusive in terms of the effectiveness of L-PRF given the great heterogeneity of the reports, lack of control for risk of bias, and information about the clinical trials. [21][22][23] To date, ARP has been analyzed by measuring wound healing, with periapical radiographs or a dental cast. 24 A volumetric analysis using computer-aided design/ and computer-aided manufacturing technology or with the overlapping of images as in Standard Tessellation Language (.stl) could contribute to the volumetric measurement in ARP.…”

mentioning

confidence: 99%

Leukocyte and Platelet-Rich Fibrin Have Same Effect as Blood Clot in the 3-Dimensional Alveolar Ridge Preservation. A Split-Mouth Randomized Clinical Trial

Aravena

Sandoval

Pizarro

et al. 2021

Journal of Oral and Maxillofacial Surgery

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Purpose: Leukocyte-and platelet-rich fibrin (L-PRF) has been used for alveolar ridge preservation (ARP) in postextraction tooth sockets. However, current reports have measured its effectiveness in linear measurements of 3-dimensional ridge preservation. The purpose of this study was to determine the effectiveness of the use of L-PRF filling versus natural clot blood healing in ARP according to the clinical, radiographic, and volumetric measurements of postextraction tooth sockets.Materials and Methods: A split-mouth randomized clinical trial was designed. Healthy patients who needed bilateral extraction of upper third molars were selected. After the tooth extraction, the socket was filled and distributed randomly with L-PRF and the contralateral socket only with the blood clot. The dimensional change of soft tissue healing around the sockets, and the length, depth, and difference of bone formation were examined using standardized periapical radiographs. Volumetric measurement variation of the sockets was evaluated by 3-dimensional scanning of dental casts. Changes of all measures were analyzed at 7 days (initial) and 3 months (final) after the tooth extraction and compared between both groups (t test; P < .05).Results: Sixteen patients (aged 24.75 AE 3.53 years; 56.25% women) participated. Measurements of wound healing and the length, depth, and difference of bone formation were similar for both study groups at initial and final times. The calculation of initial-final volumetric socket variation was 15.45 AE 13.12 mL using L-PRF and 14.12 AE 11.23 mL using blood clot (P = .78).

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Effect of platelet-rich fibrin on alveolar ridge preservation

Cited by 48 publications

References 41 publications

Implant stability in patients treated with platelet‐rich fibrin and bovine bone substitute for alveolar ridge preservation is associated with peripheral blood cells and coagulation factors

Implant stability in patients treated with platelet‐rich fibrin and bovine bone substitute for alveolar ridge preservation is associated with peripheral blood cells and coagulation factors

Autologous platelet-rich fibrin stimulates canine periodontal regeneration

Leukocyte and Platelet-Rich Fibrin Have Same Effect as Blood Clot in the 3-Dimensional Alveolar Ridge Preservation. A Split-Mouth Randomized Clinical Trial

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