2001
DOI: 10.2486/indhealth.39.317
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Effect of Platinum Coordination Complex (PtCx) on Citrate Uptake by Rat Renal Brush Border Membrane Vesicles (BBMV): Cisplatin-Intoxicated Rats.

Abstract: Platinosis with severe dermatitis and/or asthma is broadly defined as the effects of soluble platinum salts on people exposed to them occupationally. Platinum coordination complexes are widely used in the treatment of a variety of solid tumors. However, the clinical use of cisplatin, the most useful agent, is limited by the development of nephrotoxicity. Thus, an accidental exposure to soluble platinum at a high dose in platinum refineries and pharmaceutical factories could induce occupational nephrotoxicity. … Show more

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Cited by 4 publications
(3 citation statements)
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“…A major function of the kidney is the uptake of various substances including glucose, amino acids and Pi. The BBM is also the functional site of the nephron where various transporters are located.12 CDDP interferes with water and electrolyte transport by renal tubular epithelia.16'32 The Na+ gradient dependent uptake of glucose across the BBMV is inhibited in animals exposed to CDDP and in renal proximal tubular cells in primary culture.3334 CDDP administration also inhibits citrate and organic cation transport across BBM from rat kidney but has no effect on organic anion 35,36 transport.…”
Section: Discussionmentioning
confidence: 99%
“…A major function of the kidney is the uptake of various substances including glucose, amino acids and Pi. The BBM is also the functional site of the nephron where various transporters are located.12 CDDP interferes with water and electrolyte transport by renal tubular epithelia.16'32 The Na+ gradient dependent uptake of glucose across the BBMV is inhibited in animals exposed to CDDP and in renal proximal tubular cells in primary culture.3334 CDDP administration also inhibits citrate and organic cation transport across BBM from rat kidney but has no effect on organic anion 35,36 transport.…”
Section: Discussionmentioning
confidence: 99%
“…The citrate uptake was also significantly inhibited in cisplatin-intoxicated rats at 1 min compared with that of control rats 15) . To further clarify the mechanism of renal disturbance induced by vanadium exposure, in vivo experiments in vanadium-intoxicated rats are needed.…”
mentioning
confidence: 77%
“…La unión de cisplatino al ADN nuclear (DNAn) genera una marcada curvatura de la doble hélice hacia el surco mayor, lo que se traduce en un desenrrollamiento parcial de la molécula de ADN, impidiendo una correcta progresión del ciclo celular (Zamble y Lippard, 1995). Estas uniones generan además aductos covalentes impidiendo la mitosis y replicación del ADN (Sorenson y Eastman, 1988;Saris et al, 1996), siendo los más frecuentes: El daño en el ADN inducido por la formación de aductos causa muerte celular por apoptosis y por procesos no apoptóticos tales como necrosis (Sato et al, 2001;Price et al, 2004;Cepeda et al, 2007). El modo de muerte celular ha sido unida a la concentración de cisplatino usada.…”
Section: Cisplatinounclassified