Effect of PM2.5 Levels on Respiratory Pediatric ED Visits in a Semi-Urban Greek Peninsula

Kanellopoulos, Nikolaos; Pantazopoulos, Ioannis; Mermiri, Maria; Mavrovounis, Georgios; Kalantzis, George; Saharidis, Georgios K. D.; Gourgoulianis, Konstantinos

doi:10.3390/ijerph18126384

Cited by 7 publications

(13 citation statements)

References 39 publications

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“…Some supporting evidence showed that among children hospitalized for pneumonia, positive associations were seen with short-term daily exposure to ambient air pollution [ 7 , 8 ]. Similarly, pediatric patient visits to the emergency department for respiratory symptoms were also increased in those with high levels of daily PM 2.5 exposure [ 9 ]. To date, the NAAQS of China has yet to set air pollutant standards to protect “sensitive subgroups”.…”

Section: Introductionmentioning

confidence: 99%

Short-term exposure to ambient fine particulate pollution aggravates ventilator-associated pneumonia in pediatric intensive care patients undergoing cardiovascular surgeries

Cui

et al. 2023

Environ Health

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Background Ambient air pollutants can be hazardous to human health, especially for vulnerable children. The impact of ambient air pollutant exposure before and during intensive care unit (ICU) stays on the development of ventilator-associated pneumonia (VAP) in critically ill children has not been established. We aimed to determine the correlations between short-term exposures to ambient fine particulate matter (PM2.5) and VAP in pediatric cardiac surgery patients in the ICU, and explore the effect of delayed exposure. Methods The medical record of 1755 child patients requiring artificial ventilation in the ICU between December 2013 to December 2020, were analyzed. The daily average concentrations of particulate matters (PM2.5 and PM10), sulfur dioxide (SO2), and ozone (O3) were calculated from public data. Interactions between these pollutants and VAP were simulated with the distributed lag non-linear model. Results Three hundred forty-eight cases (19.829%) of VAP were identified in this study, while the average concentrations of PM2.5, PM10, O3 and SO2 were 58, 118, 98 and 26 μg/m3, respectively. Exposure to increased levels of PM2.5 two days prior (lag 2-day) to VAP diagnosis is significantly correlated with an enhanced risk for VAP development. Even a slight increase of 10 μg/m3 in PM2.5 can translate to a 5.4% increase in VAP incidence (95% CI: 1.4%-9.5%) while the VAP incidence increased to 11.1% (95%CI: 4.5–19.5%) when PM2.5 concentration is well below the National Ambient Air Quality standard (NAAQS) of 50 μg/m3. The association was more pronounced in those aged below 3-months, with low body mass index or suffered from pulmonary arterial hypertension. Conclusion Short-term PM2.5 exposure is a significant risk for development of VAP in pediatric patients. This risk is present even with PM2.5 levels below the NAAQS. Ambient PM2.5 may represent a previously unrecognized risk factor for pneumonia and the current environmental pollution standards need to be reevaluated to consider susceptible populations. Trial registration The trial was registered with the National Clinical Trial Center: The correlation between ambient air pollution and the complications in ICU underwent cardiac surgery. Trial registration number: ChiCTR2000030507. Date of registration: March 5, 2020. URL of trial registry record: http://www.chictr.org.cn/index.aspx.

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Section: Introductionmentioning

confidence: 99%

Short-term exposure to ambient fine particulate pollution aggravates ventilator-associated pneumonia in pediatric intensive care patients undergoing cardiovascular surgeries

Cui

et al. 2023

Environ Health

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“…RRTIs are defined as a minimum of six to eight episodes per year, affecting 15%–20% of children under 5 years of age ( 2 ). The incidence of RRTIs has been increasing in recent years due to deterioration caused by environmental pollution and changes in lifestyle (e.g., early socialisation of children) ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study

et al. 2022

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Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population.

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“…A large number of researches results show that [1][2][3] , PM2.5 has great harm to human health, especially the respiratory system, heart disease and cardiovascular and cerebrovascular diseases. PM2.5 is one of the important factors that affect people's quality of life and human health.…”

Section: Introductionmentioning

confidence: 99%

PM2.5 prediction based on PCA-EDWaveNet-LSTM

Zhou

Zhu

Jin

et al. 2022

Second International Conference on Advanced Algorithms and Signal Image Processing (AASIP 2022)

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At this stage, the PM2.5 concentration prediction algorithm ignores the influence of other air pollution factors, and has not realized the time-dependent integration with the influence of other environmental pollutants. In this regard, the PCA-EDWavenet-LSTM algorithm considering other air pollution characteristics is proposed. The algorithm proposes to consider other air pollution factors, combine the influence of other air pollution factors with the times dependence on PM2.5 particle concentration, and establish a PCA-EDWaveNet-LSTM algorithm based on air pollution characteristics. In the empirical analysis of PM2.5 historical concentration prediction in Xi'an, the algorithm is compared with RF_Regression algorithm, SVM algorithm, and LSTM neural network. The results show that the prediction performance of this algorithm is better than various traditional prediction algorithms in PM2.5 concentration prediction.

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Effect of PM2.5 Levels on Respiratory Pediatric ED Visits in a Semi-Urban Greek Peninsula

Cited by 7 publications

References 39 publications

Short-term exposure to ambient fine particulate pollution aggravates ventilator-associated pneumonia in pediatric intensive care patients undergoing cardiovascular surgeries

Short-term exposure to ambient fine particulate pollution aggravates ventilator-associated pneumonia in pediatric intensive care patients undergoing cardiovascular surgeries

Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study

PM2.5 prediction based on PCA-EDWaveNet-LSTM

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