Effect of Point Spread Function Deconvolution in Reconstruction of Brain 18F-FDG PET Images on the Diagnostic Thinking Efficacy in Alzheimer's Disease

Doyen, Matthieu; Mairal, Elise; Bordonné, Manon; Zaragori, Timothée; Roch, Véronique; Imbert, Laëtitia; Verger, Antoine

doi:10.3389/fmed.2021.721551

Cited by 5 publications

(5 citation statements)

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“…Acquisitions were recorded over a 15 min single bed position and all brain PET scans were reconstructed with the OSEM iterative reconstruction algorithm, as used in clinical practice, and corrected for PSF (Point Spread Function), attenuation, random coincidences, and scatter. Reconstruction parameters were based on two iterations of 10 subsets, displayed in a 256 × 256 matrix with 1 × 1 × 1 mm 3 (Doyen et al, 2021 ). The acquisition was then followed by the whole-body 18 F-FDG PET for which the patient was referred.…”

Section: Methodsmentioning

confidence: 99%

Interactions Between Brain 18F-FDG PET Metabolism and Hemodynamic Parameters at Different Ages of Life: Results From a Prospective Cross-Sectional Study

Zimmermann

Joly

Schoepfer

et al. 2022

Front. Aging Neurosci.

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Brain 18F-FDG PET imaging is useful to characterize accelerated brain aging at a pre-symptomatic stage. This study aims to examine the interactions between brain glycolytic metabolism and hemodynamic parameters in different age groups.Methods: A total of 72 patients (from 23 to 88 years of age, 38 women) without any cerebral diseases but with available cardiac, arterial peripheral, and central blood pressure measurements as well as arterial stiffness parameters obtained from brachial pressure and applanation tonometry and a brain 18F-FDG PET scan were prospectively included into this study. Quantitative voxel-to-voxel analyses were carried out to test for negative associations between brain glycolytic metabolism and individual hemodynamic parameters (p-voxel of <0.001 for the whole population and <0.005 for age groups).Results: The heart rate parameter of the whole population showed the most extensive associations with brain metabolism (15,857 mm3, T-score: 5.1), predominantly affecting the frontal and temporal regions (69% of the volume). Heart rate for the younger age group, systolic and pulse pressure for the 41–60-year-old group, and diastolic pressure for the older group were most extensively associated with brain metabolism and mainly involved the fronto-temporal lobes (respective involvement of 52.8%, 60.9%, and 65.5%) which are also the regions implicated in accelerated brain aging.Conclusion: This cross-sectional prospective study identified extensive associations between cerebral metabolism and hemodynamic parameters, indicating common aging mechanisms. Heart rate throughout adult life, systolic and pulse pressure parameters around middle age, and diastolic pressure parameters in older patients, suggest the existence of potentially therapeutic targets to prevent accelerated brain aging.

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Section: Methodsmentioning

confidence: 99%

Interactions Between Brain 18F-FDG PET Metabolism and Hemodynamic Parameters at Different Ages of Life: Results From a Prospective Cross-Sectional Study

Zimmermann

Joly

Schoepfer

et al. 2022

Front. Aging Neurosci.

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“…A cylindrical phantom was used to measure the axial and radial PET spatial resolution of a given reconstruction configuration by calculating the full width at half maximum (FWHM) along each direction as proposed by Lodge et al (8). The phantom was filled with 64.7 MBq of 18 F, and placed at the centre of the scanner FOV, with the long axis parallel to the axis of the scanner. One end of the phantom was lifted to create a small angle with the scanner axis, in order that the phantom edge intersects the image matrix obliquely in different slices.…”

Section: Spatial Resolution Calculationmentioning

confidence: 99%

“…However, only a few studies have examined the effect of reconstruction on neuroimaging PET quantitation. These studies were primarily based on phantom scans, often using a small subject cohort usually saved for retrospective reconstruction (16)(17)(18). A notable exception is a recent study examining the impact of reconstruction parameters on [ 18 F]-FDG and [ 18 F]-flutemetamol scans of AD subjects (21).…”

Section: Introductionmentioning

confidence: 99%

Impact of PET reconstruction on Aβ-amyloid quantitation in cross-sectional and longitudinal analyses

Ruwanpathirana

Williams

Masters

et al. 2023

Preprint

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Amyloid beta β accumulation in Alzheimer′s disease (AD) is typically measured using standardized uptake value ratio (SUVR) and the Centiloid scale (CL). The low spatial resolution of PET images is known to degrade quantitative metrics due to the partial volume effect (PVE). This paper examines the impact of spatial resolution, as determined by the reconstruction configuration, on the β-PET quantitation in both cross-sectional and longitudinal data. Methods: Cross-sectional Study-89 subjects with [18F]-florbetapir scans (44 β-, 45 β+) were reconstructed using 69 reconstruction configurations. For each reconstruction, β SUVR was calculated and the spatial resolution was calculated as full-width-at-half-maximum (FWHM) using the barrel phantom method (Lodge et al, 2018). The change of SUVR and the effect size of the difference in SUVR between β- and β+ groups with FWHM were examined. Longitudinal study-79 subjects (46 β-, 33 β+) with three [18F]-flutemetamol scans were analysed. All scans were reconstructed using low-, medium- and high-resolution reconstruction configurations and β CLs were calculated. Since linear β accumulation was assumed over a 10-year interval, for each reconstruction configuration, β accumulation rate differences (ARD) between the second and first periods were calculated for all the subjects and compared. Zero ARD was used as a consistency metric. The number of β-accumulators was also used to compare reconstruction configurations. Results: Cross-sectional-SUVRs in both β- and β+ groups were impacted by the FWHM of the reconstruction method; β- SUVRs increased for FWHM ≥ 4.5 mm, while β+ SUVRs decreased across the FWHM range. High-resolution reconstructions provided the best statistical separation between groups. Longitudinal study-In the β- group, the median ARD of low-resolution reconstructed data was greater than zero whereas the ARDs of higher-resolution reconstructions were not significantly different to zero, indicating less consistent rates in the low- than the higher-resolution data. Higher-resolution reconstructions identified 10 additional β-accumulators in the β- group, resulting in a 22% increased group size compared to the low-resolution reconstructions. Higher-resolution reconstructions reduced the average CL values of the negative group by 12 points.

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“…Positron emission tomography (PET) imaging works by imaging an injected radioactive tracer that combines with negative electrons to produce annihilating photons (Zhang et al, 2019;Hu et al, 2020;Zeng et al, 2020). PET imaging provides functional information on a wide range of biochemical and physiological processes (Delcroix et al, 2021;Doyen et al, 2021). To monitor rapid changes in tracer distribution, the scan time per frame is short, thus resulting in poor image quality when images are reconstructed by traditional methods under low-count conditions (Wang and Qi, 2015;Wang, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dynamic PET Imaging Using Dual Texture Features

Ouyang

Zhao

Cheng

et al. 2022

Front. Comput. Neurosci.

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Purpose: This study aims to explore the impact of adding texture features in dynamic positron emission tomography (PET) reconstruction of imaging results.Methods: We have improved a reconstruction method that combines radiological dual texture features. In this method, multiple short time frames are added to obtain composite frames, and the image reconstructed by composite frames is used as the prior image. We extract texture features from prior images by using the gray level-gradient cooccurrence matrix (GGCM) and gray-level run length matrix (GLRLM). The prior information contains the intensity of the prior image, the inverse difference moment of the GGCM and the long-run low gray-level emphasis of the GLRLM.Results: The computer simulation results show that, compared with the traditional maximum likelihood, the proposed method obtains a higher signal-to-noise ratio (SNR) in the image obtained by dynamic PET reconstruction. Compared with similar methods, the proposed algorithm has a better normalized mean squared error (NMSE) and contrast recovery coefficient (CRC) at the tumor in the reconstructed image. Simulation studies on clinical patient images show that this method is also more accurate for reconstructing high-uptake lesions.Conclusion: By adding texture features to dynamic PET reconstruction, the reconstructed images are more accurate at the tumor.

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Effect of Point Spread Function Deconvolution in Reconstruction of Brain 18F-FDG PET Images on the Diagnostic Thinking Efficacy in Alzheimer's Disease

Cited by 5 publications

References 10 publications

Interactions Between Brain 18F-FDG PET Metabolism and Hemodynamic Parameters at Different Ages of Life: Results From a Prospective Cross-Sectional Study

Interactions Between Brain 18F-FDG PET Metabolism and Hemodynamic Parameters at Different Ages of Life: Results From a Prospective Cross-Sectional Study

Impact of PET reconstruction on Aβ-amyloid quantitation in cross-sectional and longitudinal analyses

Dynamic PET Imaging Using Dual Texture Features

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