Effect of pollen extract on the development of experimental atherosclerosis in rabbits

Wójcicki, J; Samochowiec, L; Bartłkomowicz, B.; Hinek, Aleksander; Jaworska, Marzena; Gawrońska-Szklarz, B

doi:10.1016/0021-9150(86)90017-1

Cited by 31 publications

(28 citation statements)

References 16 publications

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“…Previous studies affirmed the role of cholesterol crystals within atherosclerotic plaque in promoting local inflammation and inciting plaque instability via activation of NLRP3 inflammasome 41 42. In animal models, colchicine has been shown to prevent the development of atherosclerosis and to reduce crystal-induced inflammation 43 44. Another interesting observation from animal studies revealed that colchicine works synergistically when combined with atorvastatin in reducing serum CRP and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and improving nitric oxide production in hyperlipidemic rat model 45.…”

Section: Colchicine In Cardiac Diseasesmentioning

confidence: 96%

Colchicine in cardiovascular disease: an ancient drug with modern tricks

Tong

Wilson

Layland

2016

Heart

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From the dark history of being a poison and purgative, colchicine has risen to become one of the few irrefutable positives in the history of pharmacology in the management of myriad inflammatory conditions. Colchicine exerts its action through binding to tubulin, which in turn affects several cellular processes and pathways modulating the inflammatory response. Despite narrow therapeutic-toxicity window and the most common complaint of gastrointestinal upset, its list of medicinal use is expanding in recent years as we continue to unravel the mystery of this ancient remedy. In this review, we summarise the history of colchicine use, discuss its pharmacokinetics and mechanism of actions, and examine the most up-to-date evidence of colchicine in the treatment of various cardiac conditions with a focus on cardiovascular disease.

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Section: Colchicine In Cardiac Diseasesmentioning

confidence: 96%

Colchicine in cardiovascular disease: an ancient drug with modern tricks

Tong

Wilson

Layland

2016

Heart

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“…Cernitin, another pollen extract that has been shown to have hypolipidemic and antioxidant effects 78,79 , was found to inhibit the human prostate cell lines, whereas the non-prostate-derived cells exhibited variable degrees of resistance 80 . Seventy-nine BPH patients, aged 62-89 years, were treated with cernitin at a dose of 126 mg, three times a day, for 12 weeks to over 1 year.…”

Section: Cernitinmentioning

confidence: 99%

Phytotherapy for prostatism

Xiao

Zhou

2001

The Aging Male

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Phytotherapy has won popular appreciation world-wide in the last few years with advocates proposing that herbs have the advantage of being reasonably effective, of producing fewer side-effects, and of being less costly compared with standard pharmaceutical therapies. PC-SPES is a combination of eight herbs effective for the treatment of prostate cancer patients, including androgen-dependent and androgen-independent cancers, with an overall improvement of morbidity and immune status, even in those in whom conventional therapy has failed. The preparation is estrogenic; however, its therapeutic activity is not only due to its estrogenicity, and the mechanism of action seems to be complicated. The constituent herbs of the preparation possess antitumor, antioxidant, immunomodulatory and anti-inflammatory activities, all of which may contribute to the therapeutic action of PC-SPES on prostate cancer. Further studies are needed to ascertain its long-term effect and safety, and to identify the active compounds and clarify their mechanisms of action.Saw palmetto may have a significant effect on urinary flow rates and symptom scores compared to placebo in men with benign prostatic hyperplasia (BPH) mainly as a result of its 5 -reductase inhibitory activity. Compared with finasteride, saw palmetto produces similar improvement in urinary tract symptoms and urinary flow and is associated with fewer adverse events. Hypoxis rooperi, Secale cereale and Pygeum africanum also appear to somewhat improve BPH symptoms, but the evidence seems less convincing for the use of Urtica dioica or Curcubita pepo alone in the treatment of BPH. The view, that the effects of all the plant products are no better than those of placebo, seems to be a little dogmatic. However, large-scale, placebo-controlled trials using standardized preparations with longer study durations are needed to determine their long-term effectiveness and safety.

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“…This cholesterol-lowering effect is mainly due to Panax ginseng and flower pollen. [21][22][23] It has been shown that Panax ginseng lowers cholesterol and triglyceride levels by activating lipoprotein lipase in hyperlipidemic rats. 22 In this study, however, the rats were normal and 28 days of Etana administration did not cause any significant change in the triglyceride levels.…”

Section: -13mentioning

confidence: 99%

A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals

et al. 2009

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We present herein a new herbal combination called Etana that is composed of five herbal extracts including Panax quinquelotius (Ginseng), Eurycoma longifolia (Tongkat Ali), Epimedium grandiflorum (Horny goat weed), Centella asiatica (Gotu Kola) and flower pollen extracts. Most of the above-mentioned extracts have a long historical and traditional use for erectile dysfunction (ED). On the basis of the mechanism of action of each of the above, a combination is introduced to overcome several physiological or induced factors of ED. This study was conducted to show an enhancement of erectile function in male rats. The animals were observed for 3 h after each administration for penile erection, genital grooming and copulation mounting, and the penile erection index (PEI) was calculated. The maximum response was observed at the concentration of 7.5 mg kg -1 of Etana. At a 7.5 mg kg -1 single dose, the percentage of responding rats was 53±7 with a PEI of 337±72 compared with 17±6 with a PEI of 30±10 for control animals. This PEI was significantly (Po0.001) higher than each single component and than the sum of any two herbal components of Etana. When compared with sildenafil citrate, Etana induced more pronounced PEI than 0.36 mg kg -1 , but similar to 0.71 mg kg -1 of sildenafil. Furthermore, full acute and sub-acute toxicity studies showed no toxic effects of Etana. In conclusion, this study describes a new and safe combination of herbal components that enhance erectile function in male rats. Clinical studies are warranted for evaluating Etana's significance in ED.

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Effect of pollen extract on the development of experimental atherosclerosis in rabbits

Cited by 31 publications

References 16 publications

Colchicine in cardiovascular disease: an ancient drug with modern tricks

Colchicine in cardiovascular disease: an ancient drug with modern tricks

Phytotherapy for prostatism

A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals

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