Effect of poly ethylene glycol on the mechanical and thermal properties of bioactive poly(ε-caprolactone) melt extrudates for pharmaceutical applications

Douglas, Paula; Albadarin, Ahmad B.; Sajjia, M.; Mangwandi, Chirangano; Kuhs, Manuel; Collins, Maurice N.; Walker, Gavin

doi:10.1016/j.ijpharm.2016.01.036

Cited by 45 publications

(39 citation statements)

References 19 publications

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“…Overall these results suggest that the addition of 1 and 3 wt% unmodified and modified cellulose causes an increase in the crystallinity due to an increase in mobility of the PLA chains . However, the addition of 5 wt% modified cellulose leads to restricted chain movement due to PLA/cellulose interactions which leads to a drop in crystallinity.…”

Section: Resultsmentioning

confidence: 75%

“…a and b). The glass transition range becomes broader as the percentage of cellulose is increased, suggesting that the addition of cellulose causes an increase in the crystallinity due to an increase in mobility of the PLA chains . With the addition of 3 and 5 wt% for both unmodified and modified cellulose, the glass transition becomes weaker on the DSC curves.…”

Section: Resultsmentioning

confidence: 99%

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Microcrystalline cellulose reinforced polylactic acid biocomposite filaments for 3D printing

2016

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The aim of this study was to produce a novel microcrystalline cellulose (MCC) reinforced polylactic acid (PLA), fully degradable biocomposites for 3D printing applications. The biocomposites were produced in filament form by solvent casting and twin screw extrusion to achieve final concentrations of 1, 3, and 5 wt% of cellulose. In order to improve compatibility with the PLA, the cellulose was surface‐modified using a titanate coupling agent. Influence of cellulose content and modification on the morphological, mechanical, and thermal properties of the biocomposites were studied. Differential scanning calorimetry results reveal an increase in crystallinity for all biocomposites, with 3 wt% surface‐modified cellulose displaying highest values. Dynamic mechanical thermal analysis results show that storage modulus increased for all biocomposites when compared with neat PLA, with the most significant increase associated with the 3 wt% modified cellulose. The surface modification of cellulose shifted the tan delta peak of the 1 and 3 wt% biocomposite toward lower temperatures, indicating an increased mobility of the PLA chains. Finally, the extruded cellulose reinforced PLA filaments were successfully 3D printed using a fused deposition modeling technique. POLYM. COMPOS., 39:1311–1320, 2018. © 2016 Society of Plastics Engineers

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Microcrystalline cellulose reinforced polylactic acid biocomposite filaments for 3D printing

2016

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“…For pure PCL, there is a slightly shifted peak at 1171 cm −1 , which could be ascribed to the C-O and C-C stretching in the amorphous phase [28]. Peaks of both pure materials were found in the blend compositions, but there are no shifts or new peaks visible indicating possible intermolecular interactions [29,32]. …”

Section: Resultsmentioning

confidence: 99%

Fabrication of Cell-Loaded Two-Phase 3D Constructs for Tissue Engineering

et al. 2016

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Hydrogel optimisation for biofabrication considering shape stability/mechanical properties and cell response is challenging. One approach to tackle this issue is to combine different additive manufacturing techniques, e.g., hot-melt extruded thermoplastics together with bioplotted cell loaded hydrogels in a sequential plotting process. This method enables the fabrication of 3D constructs mechanically supported by the thermoplastic structure and biologically functionalised by the hydrogel phase. In this study, polycaprolactone (PCL) and polyethylene glycol (PEG) blend (PCL-PEG) together with alginate dialdehyde gelatine hydrogel (ADA-GEL) loaded with stromal cell line (ST2) were investigated. PCL-PEG blends were evaluated concerning plotting properties to fabricate 3D scaffolds, namely miscibility, wetting behaviour and in terms of cell response. Scaffolds were characterised considering pore size, porosity, strut width, degradation behaviour and mechanical stability. Blends showed improved hydrophilicity and cell response with PEG blending increasing the degradation and decreasing the mechanical properties of the scaffolds. Hybrid constructs with PCL-PEG blend and ADA-GEL were fabricated. Cell viability, distribution, morphology and interaction of cells with the support structure were analysed. Increased degradation of the thermoplastic support structure and proliferation of the cells not only in the hydrogel, but also on the thermoplastic phase, indicates the potential of this novel material combination for biofabricating 3D tissue engineering scaffolds.

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“…Note that the T g reported is not corrected for any hydrophilic polymer used in polymersomes, as this is different for each specific case. For example, polycaprolactone (PCL) has a T g of −55 °C, but this T g increases in the presence of larger PEG units, up to −50 °C for 25 % PEG …”

Section: Polymer Compositionsmentioning

confidence: 99%

“…The backbone of PCL consists of ester linkages that are biodegradable, and the rate of degradation is relatively slow due to its crystalline structure. Therefore, PCL applications are mainly focused on long‐term drug delivery and cell‐based therapies . Compared to other biodegradable aliphatic polyesters, PCL has several advantages: high permeability to small drug molecules, maintenance of a neutral pH environment upon degradation, facility in forming blends with other polymers, and slow erosion kinetics suitable for long‐term delivery as compared to polylactide (PLA), polyglycolide (PGA), and polylactic‐co‐glycolic acid (PLGA)…”

Section: Polymer Compositionsmentioning

confidence: 99%

Designing Molecular Building Blocks for Functional Polymersomes

Rijpkema

Toebes

Maas

et al. 2019

Israel Journal of Chemistry

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In recent years various polymeric vesicles have been reported that show promising results for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles can be assembled from many different materials and various coupling reactions have been applied for functionalization of the vesicles. However, the designs reported are still rather simple, as it is challenging to mimic biological complex systems. In this review we focus on the properties of widely used hydrophobic polymers to better understand polymersome properties for various applications. Examples are shown of how researchers have used and modulated block‐copolymers and their properties to their advantage. Furthermore, an overview of possible end group functionalizations of nanoparticles is reported, giving insight in recent developments of smart nanoparticles for biomedical applications.

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Effect of poly ethylene glycol on the mechanical and thermal properties of bioactive poly(ε-caprolactone) melt extrudates for pharmaceutical applications

Cited by 45 publications

References 19 publications

Microcrystalline cellulose reinforced polylactic acid biocomposite filaments for 3D printing

Microcrystalline cellulose reinforced polylactic acid biocomposite filaments for 3D printing

Fabrication of Cell-Loaded Two-Phase 3D Constructs for Tissue Engineering

Designing Molecular Building Blocks for Functional Polymersomes

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