Effect of Poly(Vinyl Pyrrolidone) on Iodine Release from Acrylate‐Endcapped Urethane‐Based Poly(Ethylene Glycol) Hydrogels as Antibacterial Wound Dressing

Mignon, Arn; Gheysens, Tom; Walraet, Sander; Tack, Pieter; Rigole, Petra; Coenye, Tom; Vincze, Laszlo; Van Vlierberghe, Sandra; Dubruel, Peter

doi:10.1002/mabi.202300202

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…As a result, several AUPs, primarily utilising backbone polymers of PCL and PEG, have been evaluated for their potential applications in a biomedical setting. PEG-based AUPs in particular have seen a great deal of research into their suitability as hydrogels for wound healing, including in burn wound exudate management [18], anti-bacterial embedded dressings [19], and as novel smell-reducing materials for malodorous wounds [20]. In these implementations the PEG-based AUPs showed great promise, even producing results comparable to commercial products in some cases [18].…”

Section: Introductionmentioning

confidence: 99%

Melt electrowriting of poly(ϵ-caprolactone)—poly(ethylene glycol) backbone polymer blend scaffolds with improved hydrophilicity and functionality

Darroch,

Digeronimo,

Asaro

et al. 2024

Biomed. Mater.

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Melt electrowriting (MEW) is an additive manufacturing technique that harnesses electro-hydrodynamic phenomena to produce 3D-printed fibres with diameters on the scale of 10’s of microns. The ability to print at this small scale provides opportunities to create structures with incredibly fine resolution and highly defined morphology. The current gold standard material for MEW is poly(ε-caprolactone) (PCL), a polymer with excellent biocompatibility but lacking in chemical groups that can allow intrinsic additional functionality. To provide this functionality while maintaining PCL’s positive attributes, blending was performed with a Poly(Ethylene Glycol) (PEG)-based Acrylate endcapped Urethane-based Precursor (AUP). AUPs are a group of polymers, built on a backbone of existing polymers, which introduce additional functionality by the addition of one or more acrylate groups that terminate the polymer chain of a backbone polymer. By blending with a 20kDa AUP-PEG in small amounts, it is shown that MEW attributes are preserved, producing high-quality meshes. Blends were produced in various PCL:AUP weight ratios (100:0, 90:10 and 0:100) and processed into both solvent-cast films and MEW meshes that were used to characterise the properties of the blends. It was found that the addition of AUP-PEG to PCL significantly increases the hydrophilicity of structures produced with these polymers, and adds swelling capability compared to the non-swelling PCL. The developed blend (90:10) is shown to be processable using MEW, and the quality of manufactured scaffolds is evaluated against pure PCL scaffolds by performing scanning electron microscopy image analysis, with the quality of the novel MEW blend scaffolds showing comparable quality to that of pure PCL. The presence of the functionalisable AUP material on the surface of the developed scaffolds is also confirmed using fluorescence labelling of the acrylate groups. Biocompatibility of the MEW-processable blend was confirmed through a cell viability study, which found a high degree of cytocompatibility.

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Section: Introductionmentioning

confidence: 99%

Melt electrowriting of poly(ϵ-caprolactone)—poly(ethylene glycol) backbone polymer blend scaffolds with improved hydrophilicity and functionality

Darroch,

Digeronimo,

Asaro

et al. 2024

Biomed. Mater.

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Polymer‐ and Lipid‐Based Nanostructures Serving Wound Healing Applications: A Review

Cetin,

Mignon,

Van Vlierberghe

et al. 2024

Adv Healthcare Materials

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Management of hard‐to‐heal wounds often requires specialized care that surpasses the capabilities of conventional treatments. Even the most advanced commercial products lack the functionality to meet the needs of hard‐to‐heal wounds, especially those complicated by active infection, extreme bleeding, and chronic inflammation. The review explores how supramolecular nanovesicles and nanoparticles—such as dendrimers, micelles, polymersomes, and lipid‐based nanocarriers—can be key to introducing advanced wound healing and monitoring properties to address the complex needs of hard‐to‐heal wounds. Their potential to enable advanced functions essential for next‐generation wound healing products—such as hemostatic functions, transdermal penetration, macrophage polarization, targeted delivery, and controlled release of active pharmaceutical ingredients (antibiotics, gaseous products, anti‐inflammatory drugs, growth factors)—is discussed via an extensive overview of the recent reports. These studies highlight that the integration of supramolecular systems in wound care is crucial for advancing toward a new generation of wound healing products and addressing significant gaps in current wound management practices. Current strategies and potential improvements regarding personalized therapies, transdermal delivery, and the promising critically evaluated but underexplored polymer‐based nanovesicles, including polymersomes and proteinosomes, for wound healing.

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Effect of Poly(Vinyl Pyrrolidone) on Iodine Release from Acrylate‐Endcapped Urethane‐Based Poly(Ethylene Glycol) Hydrogels as Antibacterial Wound Dressing

Cited by 2 publications

References 21 publications

Melt electrowriting of poly(ϵ-caprolactone)—poly(ethylene glycol) backbone polymer blend scaffolds with improved hydrophilicity and functionality

Melt electrowriting of poly(ϵ-caprolactone)—poly(ethylene glycol) backbone polymer blend scaffolds with improved hydrophilicity and functionality

Polymer‐ and Lipid‐Based Nanostructures Serving Wound Healing Applications: A Review

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