Effect of polycyclic aromatic hydrocarbons on immunity

Yu, Yangyiyi; Jin, Hui; Lu, Qianjin

doi:10.1016/j.jtauto.2022.100177

Cited by 32 publications

(12 citation statements)

References 142 publications

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“…Consistent with these studies, immunosuppression was indicated to be the most common effect after exposure to PAH in general, while evidence also exists indicating that low doses of PAH can be immunostimulatory [ 10 , 13 , 14 , 15 ]. Indeed, levels of nine monohydroxylated urinary PAH metabolites as well as the interaction between PAH exposure and smoking have been found to positively correlate with the prevalence of late-stage rheumatoid arthritis [ 16 ].…”

Section: Introductionmentioning

confidence: 71%

“…In this study, we focused on benzo(a)pyrene (BaP) because of its widespread presence, with over 70% of the European population exposed to concentrations above the WHO guideline value, according to the Air Quality Report by the European Environment Agency, for example [ 8 ]. As one of the most extensively studied environmental pollutants, BaP is a polycyclic aromatic hydrocarbon (PAH) commonly found in byproducts of industrial incineration, motor vehicle emissions, and cigarette smoke [ 9 , 10 ]. BaP has been shown to suppress the production of IgM and IgG in an in vitro antibody response model of splenic suspensions, and the exposure of B6C3F1 mice to BaP resulted in a reduced number of IgM and IgG antibody plaque-forming cells in response to antigens including sheep red blood cells (SRBC) and lipopolysaccharide (LPS) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice

Zhu

Kennicott

Liang

2023

IJMS

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Studies indicate that genetic factors only account for approximately thirty percent of all autoimmune diseases, while the rest of autoimmune pathogenesis is attributed to environmental factors including toxic chemicals. To understand if and how environmental pollutants trigger autoimmunity, we investigated the effect of benzo[a]pyrene (BaP) exposure on the development of autoimmune phenotypes in the lupus-prone MRL strain. The exposure of MRL mice to BaP over the course of 8 weeks before lupus onset resulted in total body weight loss in males, while marginal changes in anti-dsDNA levels occurred. Multi-organ analyses of BaP-treated and control MRL mice suggested that the kidney is a major organ directly affected by the metabolism of benzene-containing compounds, with increased expression of BaP-target genes including Cyp4b1 and Hao2. Intriguingly, spatial transcriptomic data showed that BaP caused a drastic reduction in cell-type diversity in both the kidneys and spleen of MRL mice. Further analysis of the molecular pathways affected suggested a sex-biased effect of BaP treatment, with the upregulated expression of angiogenesis genes in the lungs and an increased deposition of C3 in the kidneys of male mice. While SLE is more common in women, the disease is more severe in male patients, with an increased risk of disease progression to renal failure and lung cancer. Our results reveal sex-biased molecular pathways stimulated by BaP which may help explain the increased likelihood of end organ damage in males with lupus.

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Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice

Zhu

Kennicott

Liang

2023

IJMS

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“…In another study [22], a negative association was reported between WBC and polycyclic aromatic hydrocarbons in an exposed human population. Air pollutants from crude oil aring, such as particulate matter and polycyclic aromatic hydrocarbons, stimulate systemic in ammatory responses in the exposed subject [23]. The platelet count, H-L ratio, ESR and IL-6 can serve as prognostic and diagnostic biomarkers and are often utilized to re ect in ammatory and immune status in chickens [24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Effect of Exposure to Crude Oil Polluted Environment on Hematological and Serological Indices in Chickens: Variability in Breed Sensitivity

Oleforuh-Okoleh,

Fakae,

Obianwuna

et al. 2024

Preprint

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Industrial petrochemical activities pose a significant threat to the ecosystem and could cause health issues in chickens reared within vulnerable areas such as the Niger Delta region of Nigeria. This study investigated the differential responses of four chicken breeds (FUNAAB Alpha FAC, Ross 308 broilers AB, native chickens-origin of crude oil exploration communities HP, and native chickens-origin of non-crude oil exploration communities NHP) to crude oil flaring using blood-borne parameters. At five weeks of age, 256 chicks were randomly assigned to two groups: control and exposed, each had four replicates (eight birds/replicate). Birds in the exposed group inhaled gaseous emissions from crude oil flared in their enclosure (three hours daily on alternate days for 35 days). Haematological indices were influenced by a decrease (p<0.05) in packed cell volume and red blood cell count in the exposed group compared with the control. A remarkable rise (p<0.05) in inflammatory markers (platelet count, erythrocyte sedimentation rate, and interleukin-6 levels (IL-6) was also observed in most breeds. The AB showed no significant changes in haematological indices or inflammatory markers, save for IL-6. For most breeds, the exposed group had higher serum levels of aspartate aminotransaminase, alanine aminotransaminase, alkaline phosphatase, creatinine, total protein, and uric acid. Evidence of oxidative stress, as indicated by increased serum malondialdehyde (p<0.05) and reduced enzymatic antioxidant defense levels of glutathione peroxidase and superoxide dismutase activity, was recorded. Our study revealed marked variations in blood parameters among breeds, with the AB(broiler) showing more resilience to hydrocarbon toxicity than breeds with indigenous genes.

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“…85 Moreover, PAH exposure has been associated with the induction of inflammation and immune system responses, such as NF-κB and MAPK pathways. 99 PM2.5 and PAHs contain reactive oxygen species (ROS) that can dysregulate the balance between antioxidants and oxidants in the body. 100 This imbalance results in increased oxidative stress, leading to cellular damage, DNA mutations and impaired repair mechanisms.…”

Section: A Ir Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

“…Signalling pathways related to vascular endothelial growth factor (VEGF) and angiopoietin pathways may also be affected 85 . Moreover, PAH exposure has been associated with the induction of inflammation and immune system responses, such as NF‐κB and MAPK pathways 99 …”

Section: Air Pollution and Endometriosismentioning

confidence: 99%

Pollution and endometriosis: A deep dive into the environmental impacts on women's health

Vallée,

Ceccaldi,

Carbonnel

et al. 2023

BJOG

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BackgroundThe interaction between pollution and endometriosis is a pressing issue that demands immediate attention. The impact of pollution, particularly air and water pollution, or occupational hazards, on hormonal disruption and the initiation of endometriosis remains a major issue.ObjectivesThis narrative review aims to delve into the intricate connection between pollution and endometriosis, shedding light on how environmental factors contribute to the onset and severity of this disease and, thus, the possible public health policy implications.DiscussionEndocrine‐disrupting chemicals (EDCs) in pollutants dysregulate the hormonal balance, contributing to the progression of this major gynaecological disorder. Air pollution, specifically PM2.5 and PAHs, has been associated with an increased risk of endometriosis by enhancing chronic inflammation, oxidative stress, and hormonal imbalances. Chemical contaminants in water and work exposures, including heavy metals, dioxins, and PCBs, disrupt the hormonal regulation and potentially contribute to endometriosis. Mitigating the environmental impact of pollution is required to safeguard women’s reproductive health. This requires a comprehensive approach involving stringent environmental regulations, sustainable practices, responsible waste management, research and innovation, public awareness, and collaboration among stakeholders.ConclusionPublic health policies have a major role in addressing the interaction between pollution and endometriosis in a long‐term commitment.

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Effect of polycyclic aromatic hydrocarbons on immunity

Cited by 32 publications

References 142 publications

Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice

Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice

Effect of Exposure to Crude Oil Polluted Environment on Hematological and Serological Indices in Chickens: Variability in Breed Sensitivity

Pollution and endometriosis: A deep dive into the environmental impacts on women's health

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