Effect of Polycythemia on Serum Lipid Profile and Oxidative Stress

Abstract

Polycythemia is generally known as a disorder that affects the stem cells in the bone marrow and is characterized by a high and excessive production of red blood cells. The current study was designed to investigate and investigate the relationship between the serum lipid profile and oxidative stress in polycythemia patients., The study included examining 85 blood samples from both gender, males and females, for patients coming to Shatra General Hospital. During the study period, all of (Hb, PCV, MDA, TC, TG, HDL, LDL, and VLDL) were examined for both patients and control groups.The current study showed an increase in the incidence of polycythemia in males, while it decreased in females, and the study showed that the incidence of polycythemia increased with age until it reached its peak in the third age group 41-50 years, then the percentage gradually decreased to a minimum in the fifth age group 61-70 years .The results of the study recorded a significant increase P <o.o5 in both the concentration of hemoglobin Hb and the packed cell volume PCV in patients with polycythemia, both real and secondary, when compared with the control group. Also, the results of the present study showed: a significant decrease P <0.05 in cholesterol concentration in the group of true polycythemia compared with the control group. A significant increase P <0.05 in concentration of triglycerides (TG) was higher in the true polycythemia group and a high significant P <0.05 in the secondary polycythemia group compared with the control group.The results indicated that there was a significant decrease P <0.05 in LDL concentration in the true polycythemia group, and a significant increase of P <0.o5 in the secondary polycythemia group compared with the control group. The results of the study also recorded a high significant decrease P <0.05 in the true polycythemia group and a significant decrease P <0.o5 in the secondary polycythemia group compared to the control group. The results also showed a significant increase P <0.05 with the concentration of VLDL in the group of true polycythemia and high Significant p <0.05 in the secondary polycythemia group compared with the control group.The results showed a significant increase P <0.05 in MDA concentration in polycythemia patients compared with the control group.