Effect of polyethylene glycol and nano clay on swelling, diffusion, network parameters and drug release behavior of interpenetrating network copolymer

Abstract

Controlled release of a drug from a biocompatible nontoxic polymer at a predetermined rate by maintaining a constant drug level for a specific time period causes its maximum utility with reduced side effect and more efficient cure of the disease. Accordingly, several composite hydrogels were synthesized by free radical crosslink copolymerization of acrylic acid (AA), acrylamide (AM), and N'N‐methylene bis acrylamide (MBA, crosslinker) in water in the presence of varied amounts of polyethylene glycol (PEG) and nano sized sodium montmorillonite (NaMMT) clay. The structures of the hydrogels were characterized. The effect of the synthesis and process parameters on the swelling, diffusion, network parameters, and drug release properties of the polymer networks were studied. The hydrogel containing 3.2 wt% NaMMT clay and 24 wt% PEG showed the best equilibrium swelling ratio (33.2 g/g), drug entrapment efficiency (86%), and drug release properties (96.6% in 30 h at pH of 7.4) for a model drug riboflavin. The results indicate a significant improvement of swelling and drug release properties of the polymer in the presence of PEG and NaMMT clay in the gel network.

The Diels-Alder Cross-Linked Gelatin/Dextran Nanocomposite Hydrogels with Silver Nanoparticles for Wound Healing Applications: Synthesis, Characterization, and In Vitro Evaluation

“…Testing the storage and loss moduli (G′/G″) of hydrogels created from Gel/Dex can assess their mechanical strength across a range of conditions, as depicted in Figure 3 a. Throughout the frequency sweep analysis, G′ consistently surpassed G″ in value, indicating the flexible nature of the hydrogels [ 28 , 36 ]. Despite this trend, initial measurements at the lowest frequency showed storage modulus values of 754 Pa for the hydrogel, and 1294, 1840, and 2869 Pa for the nanocomposite hydrogels are referred to as GD/Ag1, GD/Ag2, and GD/Ag3, respectively, as shown in Figure 3 a.…”