Effect of polyethylene glycol molecular weight on cell growth behavior of polyvinyl alcohol/carboxymethyl cellulose/polyethylene glycol hydrogel

Abstract

Polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC)/polyethylene glycol (PEG) hydrogel scaffolds are synthesized using cyclic freezing/thawing and subsequent γ‐ray irradiation to evaluate the effect of the molecular weights of PEG (200, 400, 1,000, and 2,000) on strength and cell growth behavior of the hydrogels. As the PEG weight increases from 200 to 2,000, the compressive strength and the pore size decreases gradually from 58.0 ± 8.2 kPa to 17.7 ± 6.1 kPa and from 22.7 ± 3.9 μm to 8.5 ± 1.6 μm, respectively. However, the highest swelling rate is obtained for PVA/CMC/PEG400 hydrogels. The irradiated PVA/CMC/PEG400 hydrogels exhibit tailored properties of the swelling rate of 1,148 ± 34.0%, the compressive strength of 42.5 ± 6.6 kPa, the pore size of 14.6 ± 1.9 μm, and cell viability of 184%. In addition, the fastest L‐929 cell proliferation and growth with time, verified by the cell proliferation (0–48 hr) and the scratch assay (0–15 hr), was observed for the PVA/CMC/PEG400 hydrogels, indicating that they are highly suitable for potential wound dressings that require fast healing regeneration.

A 4‐Arm PEG‐Thiodepsipeptide Precursor Enables Gelatinase‐Promoted Hydrogel Formation

“…We chose a maleimide functionalized PEG‐based precursor, as our earlier studies showed a fast reaction of liberated thiol groups with maleimide moieties on a multiarm PEG core. Functionalized multiarm PEG is suitable for hydrogel formation as shown in complex and localized hydrogel‐based biomaterials [ 48–50 ] via light‐based crosslinking reactions, [ 51 ] host‐guest interactions, and a variety of click reactions. [ 52–54 ]…”

“…We chose a maleimide functionalized PEG-based precursor, as our earlier studies showed a fast reaction of liberated thiol groups with maleimide moieties on a multiarm PEG core. Functionalized multiarm PEG is suitable for hydrogel formation as shown in complex and localized hydrogel-based biomaterials [48][49][50] via light-based crosslinking reactions, [51] host-guest interactions, and a variety of click reactions. [52][53][54] In a typical enzyme-promoted gel formation, a gelling mixture comprising PEG4MAL, PEG4TDP o , and enzymes in 100 μL tris buffer was monitored for gel formation during incubation at 37 °C.…”

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“…The swelling capacity of the cellulose hydrogels was also observed to be restricted as a higher amount of ECH crosslinker was used. This was due to the cellulose polymer networks becoming more rigid due to a higher degree of crosslinking, and thus the hydrogel networks have limited expansion [26][27][28]. However, both the optimization by RSM (Figure 2 and Figure 4) and experimental results (Figure 5) showed that the heating gelation condition had produced cellulose hydrogel with a higher swelling property as compared to the freezing method.…”

Characterization of Antibacterial Fabric Nanocomposites Based on Silver /Copper Oxide and Polymer Blend with Electron Beam Radiation

“…-Generally, the modi ed cotton fabrics with CMC-PEG-EG and those with CMC-PEG-EG/Ag/different CuO NP ratios showed marked improvements in thermal stability with higher T max values than the unmodi ed cotton fabrics. This could be attributed to the presence of chemical crosslinking reactions occurring between cotton cellulose and CMC-PEG-EG/Ag/CuO NP using EB irradiation (Shin et al,2020). The highest enhancement in the thermal stability, for both the rst and second T max , was estimated in the case of modi ed cotton fabrics with CMC-PEG-EG/Ag/different CuO NP ratios.…”