Effect of polyions on Japanese encephalitis virus Difference in interaction of virus with DEAE dextran and Dextran sulfate between PS cell adapted and non-adapted virus

Ozaki, Yoshihiko; Kumagai, Kazuaki

doi:10.1007/bf01241531

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Polyanions have been widely reported to possess resistance-enhancing properties against a host of bacterial (3,19,20), viral (16,18,21,23), or parasitic infections (12). On the other hand, Bonventre and Black-Schaffer (4) showed that DS 500 causes increased susceptibility of mice to infection with Staphylococcus aureus and Shigella flexneri.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice

Hahn

1974

Infect Immun

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Injection of dextran sulfate 500 caused loss of antibacterial resistance. Mice became more susceptible to an infection with Listeria monocytogenes and were unable to develop antilisterial immunity after both active and passive immunization with passively administered spleen cells from Listeria-immune donors. Indirect evidence suggests that the phagocytic component of cell-mediated resistance to bacterial infection is the site of attack of dextran sulfate.

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Section: Discussionmentioning

confidence: 99%

Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice

Hahn

1974

Infect Immun

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“…Dextran sulfate (DS) 500 (molecular weight, 500,000), a widely used immunological model substance (3,4,6,8,15), has been shown in mice to cause increased susceptibility to infections with the facultatively intracellular bacterium Listeria monocytogenes (7). Findings reported there suggested the main site of attack of DS 500 to be the mononuclear phagocyte.…”

mentioning

confidence: 99%

Morphological Changes Induced by Dextran Sulfate 500 in Mononuclear Phagocytes of Listeria -Infected Mice

Hahn

Bierther

1974

Infect Immun

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Morphological changes involving mononuclear phagocytes in Listeria-infected mice after treatment with dextran sulfate 500 were investigated. Mononuclear phagocytes in livers and spleens, both circulating monocytes and fixed macrophages, showed uptake of electron-dense material. Mononuclear phagocyte changes were most pronounced within granulomatous lesions, where many phagocytes showed' large membrane-bound inclusions and extensive cellular damage. It is concluded that dextran sulfate 500 selectively damages mononuclear phagocytes and that, in listerial infection, dextran sulfate 500 renders mononuclear phagocytes unable to express cellular resistance.

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Reproduction of Togaviruses

Pfefferkorn

Shapiro

1974

Reproduction: Small and Intermediate RNA Viruses

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Effect of polyions on Japanese encephalitis virus Difference in interaction of virus with DEAE dextran and Dextran sulfate between PS cell adapted and non-adapted virus

Cited by 6 publications

References 13 publications

Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice

Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice

Morphological Changes Induced by Dextran Sulfate 500 in Mononuclear Phagocytes of Listeria -Infected Mice

Reproduction of Togaviruses

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