Effect of polymer concentration on the morphology of the PHPMAA-g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation

Abstract

Successful generation of micelles, vesicles, and/or worms with controllable sizes was achieved through the self-assembly process of the poly[N-(2-hydroxypropyl)] methacrylamide-g-polylactide (PHPMAA-g-PLA) copolymer within a microfluidic channel. A product diagram was...

Microfluidic Controlled Self-Assembly of Polylactide (PLA)-Based Linear and Graft Copolymers into Nanoparticles with Diverse Morphologies

“…In our recent publication, we highlighted the significant impact of self-assembly within the MF technique, particularly evident with a typical amphiphilic PHPMAA- g -PLA GCP. This copolymer enabled the formation of nano-objects with a unique worm-like (Ws) morphology at a concentration of C final 20.0 mg mL –1 .…”

“…In our recent published papers, − we showcased the synthesis of a novel category of BCPs with linear and nonlinear architecture. Likewise, all were synthesized via a metal-free one-pot/simultaneous ROP and RAFT approach.…”

“…(A) TEM image and (B) SAXS data of recorded for the self-assembled of PHPMAA- g -PLA Ws. Adapted with permission under a Creative Commons [CC-BY 3.0] from ref Copyright 2024 Royal Society of Chemistry.…”

“…The PLA- b -PTEGMA diblock copolymer, PHPMA- g -PLA graft copolymer (GCP), and PHPMAA- g -PLA GCP , were synthesized via a one-pot/one-step protocol following previous procedures, which are detailed in the Supporting Information.…”

“…Additionally, it possesses protein-repelling characteristics and offers a prolonged blood circulation lifetime. , In 2010, Zentel et al proposed a new route toward the synthesis of functional PLA- b -PHPMAA via the combination of ROP of LA and conversion into a chain transfer agent for the subsequent RAFT polymerization . A one-step/simultaneous RAFT/ROP approach was found for the first time by our team for the copolymerization of PLA with different vinyl monomers. − It is well-known that PLA is a hydrophobic, aliphatic, biodegradable, and biocompatible synthetic biomaterial. − It has also been utilized in biomedical applications including sutures, bone screws, and tissue engineering scaffolds. , Nevertheless, controlling the size, shape, and polydispersity of soft-matter self-assembled nanostructures is an important strategy, which is why the application of microfluidic (MF) devices is greatly necessary . Indeed, MF methods featuring precise fluid manipulation have quickly become powerful and versatile for manufacturing NPs in a highly controlled manner, which is of great importance for nanoencapsulation, biomimics, and microreactors .…”