Effect of polymer microneedle pre-treatment on drug distributions in the skin <i>in vivo</i>

Hao, Yu; Yang, Yuan; Li, Qiu Yu; Zhang, Xiao Peng; Shen, Chang Bing; Zhang, Chao; Cui, Yong; Guo, Xin Dong

doi:10.1080/1061186x.2020.1757101

Cited by 14 publications

(7 citation statements)

References 31 publications

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“…The first MNs, which aimed at enhancing the skin permeability for transdermal drug delivery, were of the solid type [1]. Solid MNs are generally fabricated using silicon, metal, or polymer materials, which have sufficient mechanical strength to puncture the stratum corneum and penetrate the epidermis of human skin [6][7][8][9][10][11]. After the penetration and removal of solid MNs from the skin, drug components are transported into the dermis layer through pathways formed by the MNs.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in porous microneedles: materials, fabrication, and transdermal applications

Bao

Park

Bonfante

et al. 2021

Drug Deliv. and Transl. Res.

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In the past two decades, microneedles (MNs), as a painless and simple drug delivery system, have received increasing attention for various biomedical applications such as transdermal drug delivery, interstitial fluid (ISF) extraction, and biosensing. Among the various types of MNs, porous MNs have been recently researched owing to their distinctive and unique characteristics, where porous structures inside MNs with continuous nano- or micro-sized pores can transport drugs or biofluids by capillary action. In addition, a wide range of materials, including non-polymers and polymers, were researched and used to form the porous structures of porous MNs. Adjustable porosity by different fabrication methods enables the achievement of sufficient mechanical strength by optimising fluid flows inside MNs. Moreover, biocompatible porous MNs integrated with biosensors can offer portable detection and rapid measurement of biomarkers in a minimally invasive manner. This review focuses on several aspects of current porous MN technology, including material selection, fabrication processes, biomedical applications, primarily covering transdermal drug delivery, ISF extraction, and biosensing, along with future prospects as well as challenges. Graphical abstract

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Section: Introductionmentioning

confidence: 99%

Recent advances in porous microneedles: materials, fabrication, and transdermal applications

Bao

Park

Bonfante

et al. 2021

Drug Deliv. and Transl. Res.

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“…MNs with longer lengths can easily penetrate deeper layers of the skin, resulting in larger micro-sized holes. This allows more drugs to cross the stratum corneum (SC) to increase the permeability of the drug via the MN-created pathways [ 36 , 68 , 69 ]. Increased height of the MN can promote a vertical mannerism of drug diffusion while having a minor impact on the horizontal level of drug diffusion.…”

Section: Microneedle Insertion—behavior On Skin Layersmentioning

confidence: 99%

The Rise of Polymeric Microneedles: Recent Developments, Advances, Challenges, and Applications with Regard to Transdermal Drug Delivery

Gera

Burra

2022

JFB

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The current scenario of the quest for microneedles (MNs) with biodegradability and biocompatibility properties is a potential research area of interest. Microneedles are considered to be robust, can penetrate the skin’s deep-seated layers, and are easy to manufacture, and their applications from the clinical perspective are still ongoing with standard escalation. This review paper focuses on some of the pivotal variants of polymeric microneedles which are specifically dissolvable and swell-based MNs. It further explores the drug dissolution kinetics and insertion behavior mechanisms with an emphasis on the need for mathematical modeling of MNs. This review further evaluates the multifarious fabrication methods, with an update on the advances in the fabrication of polymeric MNs, the choice of materials used for the fabrication, the challenges in polymeric MN fabrication, and the prospects of polymeric MNs with applications pertinent to healthcare, by exclusively focusing on the procurable literature over the last decade.

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“…Furthermore, during polymer selection, the target tissue for the MN must be called transdermal or non-transdermal [ 46 , 47 ]. Aimed at soft tissues that cannot withstand pressure from the high-strength MN implant, careful balancing of strength and versatility must be considered [ 48 ]. Environmental moisture is also an important consideration, as greater moisture levels decrease the resistance of the MNs by the polymer and humidity [ 49 ].…”

Section: Materials Choice and Drug Release Kinetics Of Polymeric Microneedlesmentioning

confidence: 99%

“…Longer MNs can penetrate deeper and create longer micro-holes in the skin. As a result, more drugs can effectively move across the stratum corneum (SC), increasing drug permeability through the pathways created by the MNs [ 36 , 48 , 114 ]. Increasing the MNs height can promote the vertical and hardly affect the horizontal drug diffusion.…”

Section: Modeling and Optimization For Designing Polymeric Mnsmentioning

confidence: 99%

“…Increasing the MNs height can promote the vertical and hardly affect the horizontal drug diffusion. The dosage of drug administered can be controlled by adjusting the height of MNs for skin pretreatment, and thus more drug distribution occurs in the skin [ 24 , 48 ]. Higher density MN patches can induce higher drug diffusion horizontally as higher densities of the MNs create more micro-holes and distribute more drugs through the micro-holes into the skin.…”

Section: Modeling and Optimization For Designing Polymeric Mnsmentioning

confidence: 99%

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Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Effect of polymer microneedle pre-treatment on drug distributions in the skin in vivo

Cited by 14 publications

References 31 publications

Recent advances in porous microneedles: materials, fabrication, and transdermal applications

Recent advances in porous microneedles: materials, fabrication, and transdermal applications

The Rise of Polymeric Microneedles: Recent Developments, Advances, Challenges, and Applications with Regard to Transdermal Drug Delivery

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

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