Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model

Komprda, T.; Sládek, Z.; Vícenová, Monika; Simonová, Jana; Franke, Gabriela; Lipový, Břetislav; Matejovičová, Milena; Kacvinská, Katarína; Sabliov, Cristina M.; Astete, Carlos E.; Levá, Lenka; Popelková, Vendula; Bátik, Andrej; Vojtová, Lucy

doi:10.3390/ijms23147663

Cited by 7 publications

(2 citation statements)

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“…Concurrently, an intricate network of biological molecules such as growth factors and cytokines orchestrates this multifaceted process. The intricate orchestration of wound repair is governed by intercellular interactions characterized by dynamic and precise crosstalk among various signaling pathways [1,8–10] . Broadly, wound healing includes four sequential yet overlapping stages: hemostasis, inflammatory responses, proliferation, and tissue remodeling.…”

Section: Introductionmentioning

confidence: 99%

Emerging Trends in Nano‐Functionalized Scaffolds for Chronic Wound Healing

Koolabadi,

Taghipour,

Rouhani

et al. 2024

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This review discusses recent studies on the combination of nanoparticles (NPs) and biomaterials for the treatment of chronic wounds, especially diabetic foot ulcers (DFUs). This article provides a concise overview of several types of NPs. We will discuss how these NPs possess inherent characteristics that enhance the bioactivity, mechanical strength, tissue adhesion, and antibacterial properties of wound repairing scaffolds. Additionally, we explore their capacity to carry active substances and genes to the wound site. In this context, a comprehensive elucidation of various notable complexities associated with wound repair is provided, alongside corresponding strategies to mitigate them. So that, the adoption of NPs within wound dressings is advocated as a proficient technological approach to address each of these challenges. Furthermore, this article examines several physical and chemical techniques employed by researchers for the incorporation of NPs into scaffolds.

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Section: Introductionmentioning

confidence: 99%

Emerging Trends in Nano‐Functionalized Scaffolds for Chronic Wound Healing

Koolabadi,

Taghipour,

Rouhani

et al. 2024

ChemistrySelect

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“…Fatty acids have been shown to be essential in skin tissue reconstruction processes [32]. Animal studies have demonstrated the beneficial effect of the fatty acids present in cod liver oil on the prevention or healing of skin wounds, both topically and internally (orally as a supplement or by injection) [33][34][35][36][37][38][39][40][41][42]. Fish liver oil stimulates angiogenesis, thus promoting wound healing.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Some Dermato-Cosmetic Preparations with Marine Lipids from Black Sea Wild Stingray

et al. 2023

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The traditional knowledge about the therapeutic and nutritional value of fish has been unanimously recognized among the population since ancient times. So, thanks to the therapeutic virtues of these marine animals, it was possible to develop therapies for certain pathologies as well as the use of bioactive compounds as adjunctive therapies incorporated into the treatment regimen of patients. In the present study, stingray liver oil from wild species collected from the Romanian coast of the Black Sea was isolated and analyzed. Fatty acid analysis was performed by gas chromatography. The analysis of the distribution of fatty acids in the composition of stingray liver oil indicates a ratio of 3.68 of omega 3 fatty acids to omega 6, a ratio of 1.21 of polyunsaturated fatty acids to monounsaturated fatty acids, an iodine index of 111.85, and a total percentage of 79.24% of unsaturated fatty acids. Stingray liver oil was used to evaluate the healing action after preparing a fatty ointment. According to the experimental data, a complete regeneration capacity of the wounds was noted in 12 days without visible signs. Four emulgels with stingray liver oil were formulated and analyzed from a rheological and structural point of view in order to select the optimal composition, after which the anti-inflammatory effect on inflammation caused in laboratory rats was studied and an anti-inflammatory effect was found significant (a maximum inhibitory effect of 66.47% on the edemas induced by the 10% kaolin suspension and 65.64% on the edemas induced by the 6% dextran solution).

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