Effect of polymeric stabilizers on the size and stability of PLGA paclitaxel nanoparticles

Sakhi, Mirina; Khan, Abad; Khan, Ismail; Khan, Saeed Ahmad; Khan, Sumaira Irum; Khattak, Muzna Ali; Uddin, Mohammad Nasir; Kazi, Mohsin; Nasir, Fazli

doi:10.1016/j.jsps.2023.101697

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Size, PDI, and surface charge are used to characterize the stability of nanoparticles. Because surface energy and the surface-to-volume ratio both rise at the nanoscale, the stability of nanoparticles is a crucial parameter [ 25 ]. Important factors for physical targeting or drug delivery to particular regions are size, PDI, surface charge and %EE.…”

Section: Methodsmentioning

confidence: 99%

“…However, as Table 4 indicates, there were notable modifications to the physicochemical characteristics when the product was held at 25 • C. These alterations could be related to the clumping of particles during extended storage; however, at low temperatures, the low kinetic energy of the particles inhibits the clustering of particles and hence prevents particle collisions. Based on these findings, nanoformulations should be stored at 4 • C to ensure optimal efficacy in therapy and to avoid physical as well as chemical instability [25].…”

Section: Stability Of Nanoparticles Containing Mczmentioning

confidence: 99%

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Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Namazi,

Alrbyawi,

Alanezi

et al. 2024

Pharmaceutics

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The objective of this research was to develop a mucoadhesive delivery system that improves permeation for the administration of poorly absorbed oral medications. Thiolation of xanthan gum (XGM) was carried out by esterification with mercaptobutyric acid. Fourier-transformed infrared spectroscopy was used to confirm thiol-derivatization. Using Ellman’s technique, it was revealed that the xanthan-mercaptobutyric acid conjugate had 4.7 mM of thiol groups in 2 mg/mL of polymeric solution. Using mucosa of sheep intestine, the mucoadhesive properties of XGM and thiolated xanthan gum (TXGM) nanoparticles were investigated and we found that TXGM had a longer bioadhesion time than XGM. The disulfide link that forms between mucus and thiolated XGM explains why it has better mucoadhesive properties than XGM. A study on in vitro miconazole (MCZ) release using phosphate buffer (pH 6.8) found that TXGM nanoparticles released MCZ more steadily than MCZ dispersion did. A 1-fold increase in the permeation of MCZ was observed from nanoparticles using albino rat intestine compared to MCZ. Albino rats were used to test the pharmacokinetics of MCZ, and the results showed a 4.5-fold increase in bioavailability. In conclusion, the thiolation of XGM enhances its bioavailability, controlled release of MCZ for a long period of time, and mucoadhesive activity.

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Section: Methodsmentioning

confidence: 99%

Section: Stability Of Nanoparticles Containing Mczmentioning

confidence: 99%

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Namazi,

Alrbyawi,

Alanezi

et al. 2024

Pharmaceutics

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“… 48 Additionally, the production process for polymeric nanoparticles is relatively straightforward; stabilizers are not required as the polymer itself serves this function. 49 This inherent simplicity streamlines manufacturing processes and significantly reduces production costs, rendering polymeric nanoparticles an appealing option for drug delivery applications. With their unparalleled versatility, precise control over drug release kinetics, and ease of production, polymeric nanoparticles offer a promising avenue for advancing targeted drug delivery systems.…”

Section: Chitosan and Alginate As Basis For Nanoparticle Delivery Systemmentioning

confidence: 99%

Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery

Wathoni,

Herdiana,

Suhandi

et al. 2024

IJN

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Nanoparticle systems integrating alginate and chitosan emerge as a promising avenue to tackle challenges in leveraging the potency of pharmacological active agents. Owing to their intrinsic properties as polysaccharides, alginate and chitosan, exhibit remarkable biocompatibility, rendering them conducive to bodily integration. By downsizing drug particles to the nano-scale, the system enhances drug solubility in aqueous environments by augmenting surface area. Additionally, the system orchestrates extended drug release kinetics, aligning well with the exigencies of chronic drug release requisite for antibacterial therapeutics. A thorough scrutiny of existing literature underscores a wealth of evidence supporting the utilization of the alginate-chitosan nanoparticle system for antibacterial agent delivery. Literature reviews present abundant evidence of the utilization of nanoparticle systems based on a combination of alginate and chitosan for antibacterial agent delivery. Various experiments demonstrate enhanced antibacterial efficacy, including an increase in the inhibitory zone diameter, improvement in the minimum inhibitory concentration, and an enhancement in the bacterial reduction rate. This enhancement in efficacy occurs due to mechanisms involving increased solubility resulting from particle size reduction, prolonged release effects, and enhanced selectivity towards bacterial cell walls, stemming from ionic interactions between positively charged particles and teichoic acid on bacterial cell walls. However, clinical studies remain limited, and there are currently no marketed antibacterial drugs utilizing this system. Hence, expediting clinical efficacy validation is crucial to maximize its benefits promptly.

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“…Nano formulations for the delivery of PCL have been previously reported by many researchers [ 10 , 11 , 12 ] and shown a 10 times increase in solubility and 30% loading of PCL in nanoparticles. In the present research work, the LA-CMCS conjugate enhances the solubility and loading capacity of PCL in micelles.…”

Section: Introductionmentioning

confidence: 99%

Conjugated Linoleic Acid–Carboxymethyl Chitosan Polymeric Micelles to Improve the Solubility and Oral Bioavailability of Paclitaxel

Mubeen,

Abbas,

Shah

et al. 2024

Pharmaceutics

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Oral delivery, the most common method of therapeutic administration, has two significant obstacles: drug solubility and permeability. The challenges of current oral medicine delivery are being tackled through an emerging method that uses structures called polymeric micelles. In the present study, polymeric micelles were developed using conjugates of linoleic acid–carboxymethyl chitosan (LA-CMCS) for the oral delivery of paclitaxel (PCL). The developed micelles were evaluated by particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). When PCL was contained within micelles, its solubility increased by almost 13.65 times (around 60 µg/mL). The micelles’ zeta potentials were −29 mV, their polydispersity indices were 0.023, and their particle diameters were 93 nm. Micelles showed PCL loading and entrapment efficiencies of 67% and 61%, respectively. The sustained release qualities of the PCL release data from micelles were good. In comparison to the pure PCL suspension, the permeability of the PCL from micelles was 2.2 times higher. The pharmacokinetic data revealed that PCL with LA-CMCS micelles had a relative bioavailability of 239.17%, which was much greater than the PCL in the suspension. The oral bioavailability of PCL was effectively increased by LA-CMCS micelles according to an in vivo study on animals. The polymer choice, maybe through improved permeability, plays an essential role when assessing oral bioavailability enhancement and solubility improvement (13.65 times). The outcomes demonstrated that PCL’s solubility and pharmacokinetics were improved in the micelles of the LA-CMCS conjugate.

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Effect of polymeric stabilizers on the size and stability of PLGA paclitaxel nanoparticles

Cited by 7 publications

References 21 publications

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery

Conjugated Linoleic Acid–Carboxymethyl Chitosan Polymeric Micelles to Improve the Solubility and Oral Bioavailability of Paclitaxel

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