Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects

Abstract

IL-1a is closely related to the development and metastasis of cancer, and its polymorphisms have been reported affecting the susceptibility of malignancy tumors, yet the conclusions are controversial. Present an overall meta-analysis was performed to reach more general findings. Relevant literature was searched from Google Scholar, Web of Science, PubMed, EMBASE, CNKI database and Wanfang database, and the association among polymorphism and cancer risk was appraised by counting ORs and 95% CIs of overall and stratification analysis. The date from 15,586 cases and 18,430 controls in 40 publications were enrolled. There is significantly upregulated risk leads by rs3783553 in all genetic models, while the same tendency was found in all cancer types. The results also suggest a high risk of cancer susceptibility in patients carried rs1800587 polymorphism, of which draw out form allelic and homozygote models in overall studies, especially for cervical cancer. However, there are no significant results in analysis of rs17561. In a word, IL1A SNPs play an essential role in upregulating cancer susceptibility, and current analysis provides detail date for further study in the future.

Identification of Biomarkers Related to the Efficacy of Radiotherapy in Pancreatic Cancer

“…Another point is that IL-1α has been shown to act by recruiting adhesion, invasion, and angiogenesis molecules in pancreatic cancer cell lines co-cultured with fibroblasts (43). In addition, an important feature that demonstrates the centrality of this gene in tumor progression is its polymorphisms, where numerous SNPs of this gene were detected in different populations that can increase the predisposition and malignancy of different tumor types (44).…”

Association of angiogenesis and inflammation‑related gene functional polymorphisms with early‑stage breast cancer prognosis

“…The polymorphisms with proved functional activity are VEGFA (rs699947, rs833061, rs25648, rs1005230), IL-1β (rs1143634, rs16944), IL-1α (rs1800587) and IL-6 (rs1800795, rs1800797) (14)(15)(16)(17)(18)(19)(20)(21). Candidate gene studies as well as moderate-sized genome-wide association studies (GWAS) highlight the important role of these polymorphisms in BC risk and aggressiveness (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), although substantial heterogeneity across studies exists. The currently available results are inconsistent in terms of different ethnicity and cancer stage; therefore, it is necessary to further investigate the role of VEGFA, IL-1β, IL-1α and IL-6 gene polymorphisms in breast carcinogenesis and cancer progression.…”

“…Overexpression of the IL-1α promotes tumour invasiveness and metastasis by inducing the expression of angiogenic genes and growth factors (12). A large meta-analysis performed by Xia et al (30) showed that the IL-1α rs1800587 C allele and CC genotype are associated with increased cancer risk in general. The studies which investigated the associations between IL-1α rs1800587 polymorphism and BC survival are presented in Table VII.…”