2019
DOI: 10.1021/acs.jpcc.9b04089
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Effect of Polyol Chain Length on Proton Relaxivity of Gadolinium Oxide Nanoparticles for Enhanced Magnetic Resonance Imaging Contrast

Abstract: We present the impact of surface modifications on the magnetic resonance imaging (MRI) contrast enhancement abilities of gadolinium oxide nanoparticles. A series of gadolinium oxide nanoparticles surface-coated with polyols of different reductive abilities such as diethylene glycol (DEG), triethylene glycol (TEG), tetraethylene glycol (TeEG), and polyethylene glycol (PEG 200) were synthesized. Particle sizes of synthesized Gd2O3 nanoparticles were found to be in correlation with the chain length of glycol. An … Show more

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Cited by 23 publications
(37 citation statements)
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“…The parameters used for inversion recovery pulse sequence were as follows: matrix size = 256 × 320, slice thickness = 2 mm, spacing gap = 0, field of view (FOV) = 15 cm, phase (FOV) = 1, repetition time (TR) = 5000 ms, time of echo (TE) = 12 ms and inversion time (TI) = 100 to 4000 ms. T 2 weighted images were obtained at echo times with matrix size = 410 × 512, the repetition time (TR) = 6000 ms, and the spin echo time (TE) from 40 to 230 ms. Other parameters were similar to that of inversion recovery sequence. The signal intensity of the appropriate region of interest (ROI) were obtained at each TI and TE for the T 1 - and T 2 -weighted images, respectively, using the Siemens software and the corresponding T 1 and T 2 relaxation times were obtained by fitting these MRI signal amplitude with the nonlinear least-squares regression eqs and as given below and described previously in detail The r 1 and r 2 relaxivities were calculated from the slope of the plots of inverse relaxation times (1/ T 1 and 1/ T 2 ) versus Mn concentration, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…The parameters used for inversion recovery pulse sequence were as follows: matrix size = 256 × 320, slice thickness = 2 mm, spacing gap = 0, field of view (FOV) = 15 cm, phase (FOV) = 1, repetition time (TR) = 5000 ms, time of echo (TE) = 12 ms and inversion time (TI) = 100 to 4000 ms. T 2 weighted images were obtained at echo times with matrix size = 410 × 512, the repetition time (TR) = 6000 ms, and the spin echo time (TE) from 40 to 230 ms. Other parameters were similar to that of inversion recovery sequence. The signal intensity of the appropriate region of interest (ROI) were obtained at each TI and TE for the T 1 - and T 2 -weighted images, respectively, using the Siemens software and the corresponding T 1 and T 2 relaxation times were obtained by fitting these MRI signal amplitude with the nonlinear least-squares regression eqs and as given below and described previously in detail The r 1 and r 2 relaxivities were calculated from the slope of the plots of inverse relaxation times (1/ T 1 and 1/ T 2 ) versus Mn concentration, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…These results were, to some extent, consistent with those reported results. For instance, the relaxivity went higher as the chain length of ligand increased 26 . Meanwhile, GONs coating with PAA manifested outstanding T1 relaxivity, which previously was ascribed to the hydrogen bonds between PAA and water molecules.…”
Section: The Mri Contrast Affected By the Isoelectric Pointmentioning
confidence: 99%
“…Although the mechanism of the contrast enhancement has been substantially understood, practically, significant variation of r1 of the GONs with similar structure and surface chemistry arise the question on the influences from parameters. For example, for PAA coated Gd2O3 nanoplates with a core diameter of 2 nm, the longitudinal relaxivity showed huge variation ranging from 13.28 to 70.20 mM -1 •s -1 at 1.5 T. 17,24,29 While the r1 value of GONs coated by polyethylene glycol (PEG) mentioned in three reports also varied from 5.75 to 29.00 mM -1 •s -1 at 3 T. 26,30 The remarkable difference of r1 implied that attributing a high r1 value only to the above mentioned parameters might be limited.…”
Section: Introductionmentioning
confidence: 96%
See 1 more Smart Citation
“…Guleria, A. et al [52] reported the effect of polyol chain length on size and proton relaxivity of Gd 2 O 3 NPs for enhanced magnetic resonance imaging contrast. The authors studied the influence of various polyols with different reductive abilities on the size and morphology of prepared Gd 2 O 3 surface-coated NPs.…”
Section: Polyol Protocolmentioning
confidence: 99%