Effect of polyphenol compounds on<i>Helicobacter pylori</i>eradication: a systematic review with meta-analysis

Wang, Qiuxiang; Yao, Chengjiao; Li, Yilin; Luo, Lihong; Xie, Fengjiao; Xiong, Qin; Feng, Peimin

doi:10.1136/bmjopen-2022-062932

Cited by 14 publications

(13 citation statements)

References 71 publications

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“…Curcumin has been clinically studied in patients with inflammatory bowel disease, irritable bowel syndrome, ulcers, H pylori infections and even pancreatitis. Although early experimental studies did not confirm the eradication effect of H pylori ,18 more recent meta-analyses have demonstrated the potential additional benefits of polyphenol compounds when used in conjunction with standard triple therapy for H pylori eradication 19. Curcumin is effective in the treatment of gastric ulcers, erosions and dyspepsia,20 21 with ulcers and erosions reduced or even eradicated after administration of curcumin (3000 mg/day) for up to 12 weeks, while abdominal pain and discomfort were significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial

Kongkam,

Khongkha,

Lopimpisuth

et al. 2023

BMJ EBM

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ObjectiveTo compare the efficacy of curcumin versus omeprazole in improving patient reported outcomes in people with dyspepsia.DesignRandomised, double blind controlled trial, with central randomisation.SettingThai traditional medicine hospital, district hospital, and university hospitals in Thailand.ParticipantsParticipants with a diagnosis of functional dyspepsia.InterventionsThe interventions were curcumin alone (C), omeprazole alone (O), or curcumin plus omeprazole (C+O). Patients in the combination group received two capsules of 250 mg curcumin, four times daily, and one capsule of 20 mg omeprazole once daily for 28 days.Main outcome measuresFunctional dyspepsia symptoms on days 28 and 56 were assessed using the Severity of Dyspepsia Assessment (SODA) score. Secondary outcomes were the occurrence of adverse events and serious adverse events.Results206 patients were enrolled in the study and randomly assigned to one of the three groups; 151 patients completed the study. Demographic data (age 49.7±11.9 years; women 73.4%), clinical characteristics and baseline dyspepsia scores were comparable between the three groups. Significant improvements were observed in SODA scores on day 28 in the pain (−4.83, –5.46 and −6.22), non-pain (−2.22, –2.32 and −2.31) and satisfaction (0.39, 0.79 and 0.60) categories for the C+O, C, and O groups, respectively. These improvements were enhanced on day 56 in the pain (−7.19, –8.07 and −8.85), non-pain (−4.09, –4.12 and −3.71) and satisfaction (0.78, 1.07, and 0.81) categories in the C+O, C, and O groups, respectively. No significant differences were observed among the three groups and no serious adverse events occurred.ConclusionCurcumin and omeprazole had comparable efficacy for functional dyspepsia with no obvious synergistic effect.Trial registration numberTCTR20221208003.

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Section: Discussionmentioning

confidence: 99%

Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial

Kongkam,

Khongkha,

Lopimpisuth

et al. 2023

BMJ EBM

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“…While the raw sample from radish leaves did not show antibacterial activity, the digests did, regardless of whether they were nanoencapsulated or not, suggesting the participation of non-ITC compounds in the antibacterial response. For instance, the fiber in the sample after digestion produces the release of potential antibacterial compounds that could be retained in them, such as other phenolics not determined in this work, which are present in adult radish leaves and that have previously demonstrated their efficacy as antibacterial compounds against H. pylori [ 31 ]. Finally, none of the red radish root samples had antibacterial activity against H. pylori .…”

Section: Discussionmentioning

confidence: 99%

Influence of Source Materials, Concentration, Gastric Digestion, and Encapsulation on the Bioactive Response of Brassicaceae-Derived Samples against Helicobacter pylori

Garcia-Ibañez,

Silvan,

Moreno

et al. 2023

Microorganisms

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Isothiocyanates may have antibacterial activity against Helicobacter pylori, but there are different variables related to Brassicaceae-derived samples that could affect their efficacy. This work studied the influence of source variety, concentration, gastric digestion, and encapsulation of samples on their bioactive response against Helicobacter pylori. The antibacterial activity of raw sprouts (red cabbage and red radish) showed the highest antibacterial effect, which was consistent with a higher amount of isothiocyanates. It decreased with gastric digestion, regardless of sample encapsulation. By contrast, adult red radish leaves became antibacterial after gastric digestion. Antioxidant activity on H. pylori-infected gastric cells was similar in all samples and followed an equivalent pattern with the changes in isothiocyanates. Raw samples decreased intracellular reactive oxygen species production, but they lost this capacity after gastric digestion, regardless whether the compounds were free or encapsulated. Red cabbage sprouts, red radish sprouts, and red radish roots produced a decrease in nitric oxide production. It was consistent with a modulation of the inflammatory response and was associated to isothiocyanates concentration. Encapsulated sprout samples retained part of their anti-inflammatory activity after gastric digestion. Adult raw red radish leaves were not active, but after digestion, they became anti-inflammatory. The results obtained in this study have shown that several variables could have a significant impact on the bioactive properties of Brassicaceae-derived samples against H. pylori, providing a starting point for the design and standardization of samples with specific bioactivities (antibacterial, antioxidant, and anti-inflammatory) potentially useful for the treatment of H. pylori infection.

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“…This peptide was synthesized based on a tomato defensin and have shown antibacterial and anti-inflammatory effects against H. pylori and a variety of pathogens [120]. Other compounds from food sources, such as polyphenols, and carotenoids, have shown bactericidal effects against H. pylori, but not other peptides [106,121].…”

Section: Antimicrobialmentioning

confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

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Effect of polyphenol compounds onHelicobacter pylorieradication: a systematic review with meta-analysis

Cited by 14 publications

References 71 publications

Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial

Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial

Influence of Source Materials, Concentration, Gastric Digestion, and Encapsulation on the Bioactive Response of Brassicaceae-Derived Samples against Helicobacter pylori

Bioactive peptides as alternative treatment for Helicobacter pylori infection

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