Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis

Asgary, Sedigheh; Karimi, Raheleh; Joshi, Tanuj; Kilpatrick, Kaitlyn L.; Moradi, Sajjad; Samimi, Zeinab; Mohammadi, Elham; Farzaei, Mohammad Hosein; Bishayee, Anupam

doi:10.1016/j.phymed.2020.153359

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…The present study did not find any significant differences on ICAM-1 with mango consumption. Similar to the results of the present study, other fruits, such as avocado, cloudy apple juice, and pomegranate juice consumption did not make changes in ICAM-1 concentrations [ 26 , 29 , 30 ]. However, daily consumption of two fresh apples decreased ICAM-1 concentrations [ 31 ] as well as apple juice [ 28 , 34 ].…”

Section: Discussionsupporting

confidence: 89%

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The effects of mango consumption on vascular health and immune function

Castro,

Pedroza,

Hong

2023

Metabolism Open

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Section: Discussionsupporting

confidence: 89%

“…Likewise, pomegranate juice and vitamin C-rich apple juice decreased VCAM-1 levels post intervention [ 27 , 28 ]. However, pomegranate and apple juice have shown mixed results because other studies have not found significant differences in VCAM-1 concentrations [ [29] , [30] , [31] ].…”

Section: Discussionmentioning

confidence: 99%

The effects of mango consumption on vascular health and immune function

Castro,

Pedroza,

Hong

2023

Metabolism Open

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“…One of the earliest stages of atherosclerotic infl ammation is the adhesion of monocytes to the activated endothelial cells due to the excessive expression of adhesion molecules on their surface [39]. We have analyzed changes in sICAM-1, a type 1 intercellular adhesion molecule, and sVCAM-1, a type 1 vascular endothelial adhesion molecule [40].…”

Section:  Discussionmentioning

confidence: 99%

Trimetazidine as a Modifier of Chemotherapy-Induced Endothelium Homeostasis Disturbances

Авагимян¹,

Кактурский²

2022

Кардиология В Беларуси

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Введение. Настоящее исследование направлено на изучение взаимосвязи между эндотелиальной дисфункцией, кардиотоксичностью АС-режима химиотерапии и триметазидином опосредованной вазопротекции.Цель. Изучить вазотоксический потенциал AC-режима химиотерапии наряду с одновременной оценкой вазопротекторного потенциала триметазидина.Материалы и методы. Проведенное исследование характеризуется как фундаментальное, рандомизированное, контролируемое, экспериментальное, in vivo. С целью проведения экспериментальной работы было задействовано 80 инбредных крыс линии Wistar, которые были рандомно разделены на 4 равные группы. Модель эндотелиальной дисфункции была получена с использованием химиотерапевтического коктейля, состоящего из доксорубицина и циклофосфамида. В качестве вероятного стабилизатора функционирования эндотелия был выбран триметазидин. Курсовая дозировка доксорубицина составила 15 мг/кг, циклофосфамида – 150 мг/кг, а триметазидина – 42 мг/кг. Продолжительность эксперимента – 14 дней.Результаты. В рамках настоящего исследования оценены девиации эндотелина-1, оксида азота, а также факторов адгезии VCAM и ICAM, маркер воспаления – С-реактивный белок. Полученные данные показали, что триметазидин модифицировал усиление эндотелиальной дисфункции.Выводы: 1. АС-режим химиотерапии оказывает выраженное эндотелий-дискоординирующее воздействие. 2. Триметазидин обладает значимым вазопротекторным потенциалом. Introduction. Our research was determined to investigate the link between endothelial dysfunction, AC-mode of chemotherapy and trimetazidine-driven vasoprotection.Purpose. To investigate the AC-mode of chemotherapy-induced endothelium dysfunction and rationality of TMZ prescription.Materials and methods. The conducted study is characterized as a fundamental, randomized, controlled, experimental in vivo study. To carry out the experimental work, 80 inbred Wistar rats were involved, which were randomly divided into 4 equal groups. A model of endothelial dysfunction was generated using a direct combination of doxorubicin and cyclophosphamide. Trimetazidine was used as a probable stabilizer of endothelial activity. Course dose of doxorubicin – 15 mg/kg, course dose of cyclophosphamide – 150 mg/kg, course dose of trimetazidine – 42 mg/kg. The duration of the experiment was 14 days.Results. Within the framework of this study, deviations of endothelin-1, nitric oxide, as well as adhesion factors VCAM and ICAM, and an inflammatory marker, C-reactive protein, were evaluated.Conclusions: 1. AC-mode of chemotherapy provide pronounced endothelium discoordinating impact. 2. TMZ has sufficient vasoprotective properties.

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“…However, a systematic review and meta-analysis on the effects of pomegranate juice on vascular adhesion factors revealed no significant effect on intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin. However, it indicated that pomegranate juice can significantly reduce interleukin-6 [30]. Thus, in future, prospective controlled randomized trials with longer intervention duration may help to further elucidate pomegranate juice effects.…”

Section: Pomegranate and Obesity Insulin Resistance And Cardiovascula...mentioning

confidence: 99%

The Therapeutic Alliance between Pomegranate and Health Emphasizing on Anticancer Properties

et al. 2023

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Pomegranate is a fruit bearing-plant that is well known for its medicinal properties. Pomegranate is a good source of phenolic acids, tannins, and flavonoids. Pomegranate juice and by-products have attracted the scientific interest due to their potential health benefits. Currently, the medical community has showed great interest in exploiting pomegranate potential as a protective agent against several human diseases including cancer. This is demonstrated by the fact that there are more than 800 reports in the literature reporting pomegranate’s anticancer properties. This review is an update on the research outcomes of pomegranate’s potential against different types of human diseases, emphasizing on cancer. In addition, perspectives of potential applications of pomegranate, as a natural additive aiming to improve the quality of animal products, are discussed.

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Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis

Cited by 11 publications

References 35 publications

The effects of mango consumption on vascular health and immune function

The effects of mango consumption on vascular health and immune function

Trimetazidine as a Modifier of Chemotherapy-Induced Endothelium Homeostasis Disturbances

The Therapeutic Alliance between Pomegranate and Health Emphasizing on Anticancer Properties

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