Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial

Martin, Paul; Feltbower, Richard; Brown, Julia; Mason, Su; Mason, James; Nathan, J.; Richards, ID Gerald; Dowell, Anthony; Axon, Anthony

doi:10.1016/s0140-6736(00)02236-4

Cited by 165 publications

(147 citation statements)

References 22 publications

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“…58,59 Lower compliance did not affect overall cost-effectiveness, though absolute gains fall because screening is a 'one-off' event and compliance is likely to have a simple linear relationship with the number of deaths prevented. Those who fail to turn up for screening and treatment give rise to few costs.…”

Section: Discussionmentioning

confidence: 98%

“…The question of whether H. pylori eradication can increase the incidence of oesophagitis has been debated, 78 but recent randomised controlled trials (RCTs) of H. pylori eradication have not demonstrated any increase in such symptoms. 59 Nevertheless, the impact of widespread eradication of infection on the efficacy of PPIs in gastro-oesophageal reflux disease is unknown. Furthermore there are no good data to support the suggestion of an increase in incidence of oesophageal cancer after eradication of H. pylori.…”

Section: Discussionmentioning

confidence: 99%

“…Levels of screening uptake and compliance were set higher than those given in recent primary care studies of H. pylori screening, 58,59 on the basis that these studies were not set up to prevent gastric cancer or peptic ulcer.…”

Section: Compliancementioning

confidence: 99%

See 2 more Smart Citations

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

Roderick

Davies

Raftery

et al. 2003

Health Technol Assess

113

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

Roderick

Davies

Raftery

et al. 2003

Health Technol Assess

113

View full text Add to dashboard Cite

show abstract

“…2 The incidence of symptomatic or endoscopic GERD developing in ulcer patients cured of the infection, however, has ranged widely in other reports. [3][4][5][6][7] The results of H. pylori eradication in non-ulcer dyspepsia have been mixed, with some studies showing no benefit and others demonstrating improvement in symptoms and prevention of future ulcer disease. [8][9][10] A recent meta-analysis demonstrated modest efficacy for H. pylori eradication in alleviating dyspeptic symptoms with a number needed to treat of 19. 11 A subsequent meta-analysis using individual patient data suggested that the benefit of eradication was similar whether patients with predominant epigastric pain or predominant heartburn were studied.…”

Section: Introductionmentioning

confidence: 99%

Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro‐oesophageal reflux disease in Western patients with non‐ulcer dyspepsia

Vakil

Talley

Stolte

et al. 2006

Aliment Pharmacol Ther

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“…In the United Kingdom, Moayyedi et al found that dyspepsia-related expenditures declined after H. pylori was eradicated and that the savings were greater than the initial cost of a 'test and treat' strategy [Moayyedi et al 2000]. Lane et al also confirmed that the 'test and treat' strategy could reduce the costs associated with dyspepsia by 30% at two years after eradication [Lane et al 2006].…”

Section: Introductionmentioning

confidence: 99%

Review: Eradication of Helicobacter pylori to prevent gastroduodenal diseases: Hitting more than one bird with the same stone

Lee

Liou

et al. 2008

Therap Adv Gastroenterol

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Abstract:Helicobacter pylori (H. pylori ) are gram-negative bacteria that selectively colonizes the gastric mucosa. The prevalence of H. pylori infection varies from 20 to 50% in industrialized countries to over 80% in developing countries. The infection may persist lifelong without specific treatment. Prolonged infection and inflammation due to bacterial virulence and host genetic factors will lead to chronic gastritis. A certain portion of infected patients then develop more severe pathologies such as peptic ulcer (10-15%), gastric cancer (1%), and mucosaassociated lymphoid tissue lymphoma (50.01%). Although the majority of infected patients remain asymptomatic, much of the evidence has shown that eradication of H. pylori infection can reduce the recurrence of peptic ulcer and benefit a substantial portion of patients with nonulcer dyspepsia. Though controversial in population-based clinical trials, several cost-effectiveness analyses also reveal that H. pylori eradication is cost effective in the primary prevention of gastric cancer. Therefore, the discovery of H. pylori offers the chance to prevent several gastroduodenal diseases by means of their eradication. In other words, gastroenterologists could hit more than one bird with one stone. However, there are concerns regarding application of a 'test and treat' strategy in the general population. In this review, we will focus on current evidence of H. pylori eradication in the primary and secondary prophylaxis of gastric cancer and peptic ulcer disease.

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Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial

Cited by 165 publications

References 22 publications

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro‐oesophageal reflux disease in Western patients with non‐ulcer dyspepsia

Review: Eradication of Helicobacter pylori to prevent gastroduodenal diseases: Hitting more than one bird with the same stone

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