Effect of positive perioperative donor and recipient respiratory bacterial cultures on early post‐transplant outcomes in lung transplant recipients

Abstract

We did not identify an association between antibiotic appropriateness and 30-day mortality, hospital LOS, or ICU LOS in post-LT recipients.

Microbiological findings in bronchoalveolar lavage fluid from lung transplant patients in Sweden

“…Similar results have been reported in other studies, where the first three post‐operative months have been defined as the critical period for infections in lung transplanted patients, especially for bacterial etiology . Consistent with previous studies, we found no significant association between positive donor cultures and later microbiological findings in the absence or presence of lung infections …”

Effectiveness of short vs long‐course perioperative antibiotics in lung transplant recipients with donor positive respiratory cultures

“…1,3,4,[11][12][13][14] Staphylococcus aureus was isolated from 87 (59%) donor respiratory cultures which also aligns with recently published data that evaluated perioperative antibiotic selection in lung transplant recipients, demonstrating a predominance of Staphylococcus aureus in donor respiratory cultures. 1 In contrast, recipient respiratory cultures post-transplant were predominated by Gram-negative organisms with a higher incidence of Enterobacteriales and Pseudomonas spp. Of note, Stenotrophomonas maltophilia and Acinetobacter baumannii were more prevalent in the long-course group which may have driven prescribing of longer treatment due to recommended average treatment duration of 10-14 days for these pathogens.…”

Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients

“…While no randomized controlled trials exist to determine the optimal peri-operative antimicrobial management, retrospective studies suggest treatment with susceptibility-targeted antimicrobials is ideal. [16][17][18][19][20][21][22] Individuals with CF are often infected with organisms with changing sensitivity profiles, due to variation in the dominant strain(s) and susceptibilities. The number and range of organisms may vary due to overgrowth of a predominant organism limiting the ability of the laboratory to identify all organisms present.…”