This study assessed the bond strength of resin‐based restorative materials to fast‐setting calcium silicate cement (Aarhus Uinversity, Denmark) when treated with each of two one‐bottle universal adhesive systems. The cement surface (N = 256) was treated with a self‐priming adhesive and a self‐etch phosphate monomer‐containing adhesive with and without etching of the cement surface. Specimens then received either resin composite or compomer restorative materials (n = 32). The bond strength was measured after 1 day and 1500 thermocycles (n = 16). The failure type was visually inspected. The cement‐adhesive‐restorative material interface was visualized using scanning electron microscopy (SEM). The data were analyzed using multiple linear regression. Restorative material type, resin adhesive system, and thermocycling had a statistically significant effect on the bond strength. Compomer restorative material and self‐etch universal adhesive system demonstrated statistically significantly higher bond strength values to fast‐setting calcium silicate cement, predominantly exhibiting cement cohesive failure. Etching the cement surface enhanced the bond strength of the self‐priming universal adhesive. Thermocycling significantly reduced the bond strength. SEM showed self‐etch universal adhesive seemingly diffused over the etched cement surface compared to other groups. Self‐etch phosphate monomer‐containing universal adhesive and compomer resulted in the highest bond strength to fast‐setting calcium silicate cement.