Effect of post-prandial lipemia on canine biochemical parameters

Oliveira, Paula Lima de; Bonatto, Natália Camila Minucci; Bosculo, Maria Rachel Melo; Floriano, Beatriz Perez; Barros, Luiz Daniel de; Almeida, Breno Fernando Martins de

doi:10.1007/s00580-020-03130-y

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…24,25 However, post-prandial lipemia does not markedly influence serum creatinine concentrations in dogs. 26 Kidney injury was present in 30% of dogs treated with TPE in our study. The incidence of AKI was lower among this cohort if exposed to kidney-or CNS-toxic doses compared with dogs that did not undergo TPE.…”

Section: Discussionmentioning

confidence: 49%

“…In vitro lipemia has a negative bias on creatinine measurement in dogs, which might have contributed to this finding 24,25 . However, post‐prandial lipemia does not markedly influence serum creatinine concentrations in dogs 26 …”

Section: Discussionmentioning

confidence: 94%

“… 24 , 25 However, post‐prandial lipemia does not markedly influence serum creatinine concentrations in dogs. 26 …”

Section: Discussionmentioning

confidence: 99%

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Outcomes of 434 dogs with non‐steroidal anti‐inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange

Chalifoux

Butty

Mauro

et al. 2022

Veterinary Internal Medicne

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Background Traditional management of non‐steroidal anti‐inflammatory drug (NSAID) intoxication includes gastrointestinal decontamination, intravenous administration of fluids (IVF), and gastroprotection. Intravenous administration of lipid emulsion (ILE) and therapeutic plasma exchange (TPE) are popular novel therapeutic strategies. Hypothesis Compare outcomes of dogs treated with IVF, ILE, and TPE for NSAID intoxications and evaluate outcome predictors for drug subgroups. Animals Four hundred thirty‐four dogs with NSAID intoxications (2015‐2020). Methods Multicenter retrospective study of ibuprofen, carprofen, and naproxen intoxication. An ordinal outcome was defined as mild gastrointestinal, moderate kidney, or signs of severe central nervous system disease. Results Signs of neurological disease were overrepresented and acute kidney injury underrepresented in the TPE group among dogs exposed to kidney‐ or CNS‐toxic doses (P = .05), though all TPE dogs with signs of neurological disease had evidence of neurotoxicity at presentation. Dogs treated with IVF had a higher maximal creatinine concentration (median, 1.1 mg/dL; range, 0.4‐8.44 mg/dL) compared with IVF + ILE (median, 0.9 mg/dL; range, 0.4‐6.2 mg/dL; P = .01). Increased maximum time to presentation (P < .001), higher baseline creatinine (P < .001) and PCV (P = .007), and absence of induced emesis (P < .001) were associated with greater clinical severity. Ibuprofen toxicosis was associated with more severe clinical signs compared with carprofen (P = .03). Overall survival rate was 99%. Conclusions and Clinical Importance NSAID toxicosis generally carries an excellent prognosis in dogs. Despite similar outcomes of lower incidence of AKI in the TPE group, and slightly lower maximal creatinine concentration in dogs treated with ILE vs IVF alone, ILE and TPE should be considered in the management of severe NSAID toxicosis.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 94%

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Outcomes of 434 dogs with non‐steroidal anti‐inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange

Chalifoux

Butty

Mauro

et al. 2022

Veterinary Internal Medicne

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“…CBC was performed as previously described (Costa et al 2020;Oliveira et al 2020). Brie y, red blood cells (RBC), white blood cells (WBC) and platelet (PLT) concentrations, mean corpuscular volume (MCV), red cell distribution width (RDW), mean platelet volume (MPV) and hemoglobin were examined in a veterinary automated cell counter (ABX Micros ESV 60, Paris, France) previously calibrated and checked with commercial controls (ABX Minotrol 16, Paris, France).…”

Section: Collection Of Blood Samples and Laboratory Analysismentioning

confidence: 99%

Feline Obesity Causes Hematological And Biochemical Changes And Oxidative Stress

Martins

Ramos

Possidônio

et al. 2022

Preprint

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Obesity, an extremely important factor in feline clinical practice, is estimated to affect up to one third of the feline population. Moreover, it can trigger chronic inflammation, which could predispose to oxidative stress by increasing reactive oxygen species, thereby generating potentially irreversible cellular damage. This study analyzed hematological, biochemical and oxidative stress profiles at various degrees of feline obesity. Forty-five cats were selected and divided into three groups: control (n=17), overweight (n=13) and obese (n=15), after clinical and laboratory evaluation and body condition score. Biochemical and oxidative stress analyses were performed using a photocolorimeter and hematological analyses were performed in a veterinary cell counter. The hematological profile of obese cats showed increased mean corpuscular volume (MCV) and red cell distribution width (RDW), while their biochemical profile revealed increased HDL cholesterol and triglycerides and decreased activity of gamma-glutamyl transferase (GGT). As for oxidative stress, obese cats showed higher total antioxidant capacity (TAC), by the inhibition of 2,2’-Azino-Bis-3-Ethylbenzthiazoline-6-Sulfonic Acid (ABTS), inhibition of ABTS associated with horseradish peroxidase (ABTS+HRP), cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, while overweight cats had a higher TAC-ABTS+HRP and TAC-FRAP. We conclude that the conditions of natural obesity and overweight in the feline species alter its hematological, biochemical and oxidative stress parameters.

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“…Marked hypertriglyceridemia can cause interference in measuring specific analytes. [6][7][8] The dog's severe hypertriglyceridemia presented a diagnostic challenge due to the inability to rely on biochemical and hematological data, and provided an opportunity to evaluate effects of naturally occurring lipemia on analysis.…”

mentioning

confidence: 99%

Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog

Guarino

Cagle

Ehrhardt

et al. 2022

J Vet Emergen Crit Care

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Objective: To describe the therapeutic protocol used to normalize severe hypertriglyceridemia in a dog.Case Summary: A 7-month-old, 1.2-kg female Pomeranian presented with acute polyuria, polydipsia, and ocular discoloration. Diagnoses included diabetic ketosis, severe hypertriglyceridemia (>225 mmol/L [>20,000 mg/dl]), lipemia retinalis, and bilateral uveitis. The triglyceride concentration was near normal within 2 days of initiating treatment with fenofibrate, regular insulin constant rate infusion (CRI), manual therapeutic plasma exchange (TPE), and a low-fat diet. All clinical signs resolved. The dog has had no relapse of hypertriglyceridemia at the time of writing the manuscript, 6 months later, with continued treatment of diabetes mellitus.New or Unique Information Provided: This is the first case report documenting the combination of fenofibrate, insulin CRI, and manual TPE for treatment of severe hyperlipidemia in a dog. Detailed protocols for manual TPE and a novel insulin CRI are provided. A discussion of multiple spurious biochemical and hematologic errors associated with the severe hypertriglyceridemia is also provided. K E Y W O R D Sfenofibrate, glargine U300, insulin constant rate infusion, lipemia retinalis, manual therapeutic plasma exchange INTRODUCTIONHypertriglyceridemia is a negative prognostic indicator in hospitalized dogs. 1 In people, severe hypertriglyceridemia (>11.

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Effect of post-prandial lipemia on canine biochemical parameters

Cited by 9 publications

References 12 publications

Outcomes of 434 dogs with non‐steroidal anti‐inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange

Outcomes of 434 dogs with non‐steroidal anti‐inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange

Feline Obesity Causes Hematological And Biochemical Changes And Oxidative Stress

Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog

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