One hundred and twenty single-root teeth were selected to evaluate the bonding durability of three different adhesive resin cements to intra-radicular dentin and the effect of ethylenediaminetetraacetic acid (EDTA) irrigation on bonding durability, over six months of water storage. We found that water storage, type of cement, post space pretreatment, and root region were significant factors affecting the push-out bond strength. Water storage reduced the bond strength of RelyX Unicem (RU), especially in the apical region (P<0.05). Super Bond C&B (SB) was stronger than the other two cements, sometimes significantly so. The apical region had the lowest bond strength in all circumstances, although the difference was not always statistically significant. Irrigation with EDTA improved the bond strengths of Panavia F (PF) and RU significantly in each root region (P<0.05). These results showed that water storage decreased the bonding effectiveness of the adhesive resin cements. Irrigation with EDTA after post space preparation was a valuable procedure, especially when used in conjunction with self-etching adhesive or self-adhesive resin cements.As most bonding failures occur at the dentincement interface rather than at the post-cement interface (Faria e Silva et al., 2007;Radovic et al