Effect of Posture and Insulin Hypoglycemia on Catecholamine Excretion in the Newborn<sup>1</sup>

Greenberg, Robert E.; Lind, John; Euler, U. S. v.

doi:10.1111/j.1651-2227.1960.tb16088.x

Cited by 36 publications

(11 citation statements)

References 14 publications

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“…Noradrenaline excretion is unaffected by this stimulus. The response is uniform and has been elicited from the newborn infant as early as the second day of life [4].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Adrenal Medulla in the Hypoglycemia of Foetal Malnutrition

Stern¹,

Sourkes²,

Räihä³

1967

Neonatology

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“…Noradrenaline excretion is unaffected by this stimulus. The response is uniform and has been elicited from the newborn infant as early as the second day of life [4].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Adrenal Medulla in the Hypoglycemia of Foetal Malnutrition

Stern¹,

Sourkes²,

Räihä³

1967

Neonatology

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“…In the CORNBLATH series, the 3-and 5-h measurements were not made and the observations were discontinued after 6 h. Levels of catecholamine excretion, with means and standard error of the mean, are given in table III. The large patient-to-patient variability has been the experience of others [5,6,11,12,14]. Comparison of the means by groups revealed no significant differences in individual or total catecholamine excretions.…”

Section: Resultsmentioning

confidence: 96%

“…It is generally accepted that the human newborn can release catecholamines in response to specific stimuli during week 1 of life. GREENBERG «i aL [6] demonstrated a selective rise of epinephrine in the urine in seven infants, aged 2-7 days, whose blood sugars (HagedornJensen method) were reduced at least 30% by the injection of insulin. Norepinephrine excretion was unchanged by the hypoglycemic stimulus.…”

Section: Resultsmentioning

confidence: 99%

“…5 All infants except C5 had a normal course during the neonatal period; C5 had a rectal abscess. 6 Patients were examined three times during the first year of life: at 4 months, all were normal, but patients Al, A8, A10, All, and B2 were not examined; at 8 months, all were again normal, hut patients A13, B2, and C4 were not examined; at 1 year all were normal, but again patients A13, B2, and C4 were not examined. Patient C3 was examined again at 36 months and found to be normal.…”

Section: Resultsmentioning

confidence: 99%

“…In this study, all hypoglycemic infants appeared to have adequate stores of liver glycogen which were mobilized readily by exogenous epinephrine. It had previously been shown that newborn infants are capable of responding to insulin-induced hypoglycemia with increased excretion of epinephrine in the urine [6]. This seeming paradox raised the question of the capability of hypoglycemic newborns to release endogenous catecholamines in response to a hypoglycemic stimulus.…”

Section: Introductionmentioning

confidence: 99%

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Catecholamine Excretion in Spontaneously Occurring Asymptomatic Neonatal Hypoglycemia

et al. 1970

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ExtractTwenty-six full-term infants delivered vaginally were studied. There were 16 males and 10 females. Capillary blood samples for glucose were obtained hourly. When the infant voided spontaneously, the urine collection for determination of epinephrine (E), norepinephrine (NE), metanephrine (M), normetanephrine (NM), and vanillylmandelic acid (VMA) was discontinued. Using the value of 30 mg/100 ml as the lower limit of normal for glucose in blood, the study patients were divided into three groups: group A (16 subjects), all values over 30 mg/100 ml; group B (5 subjects), one value under 30 mg/100 ml; group G (5 subjects), two or more values less than 30 mg/100 ml.Comparison of the means by groups revealed no significant differences in individual or total catecholamine excretions. The two patients who were judged to be the most severely hypoglycemic, however, showed the lowest epinephrine excretions of the entire study group. Nonparametric statistical analysis was used to compare the epinephrine excretion of the 16 patients who maintained a normal glucose level with that of the 10 patients of groups B and C. A P value of less than 0.05 was obtained, suggesting that the ability to maintain adequate blood glucose was associated with a higher epinephrine excretion. Nonparametric statistical analyses did not show a significant difference in E+M or E +M+VMA excretion among the study groups. This negative finding does not support our hypothesis of deficient epinephrine release as a contributory factor in spontaneous neonatal hypoglycemia.Catecholamines in urine were determined in nine newborns who were treated in a fashion similar to the study groups except that they were not subjected to heel punctures as repeated unpleasant stimuli. The results, expressed as mean±SD were: E, 7.73±5.36; NE, 35.3±22.9; M, 52.8±33.9; NM, 201 ±140; and VMA, 899±356 ng/kg/h. The only significant difference between these values and those of the study group lay in the levels of epinephrine excretion where significant differences were found between these subjects and those in group A. It appears reasonable to attribute the observed difference to the lack of stimulation by heel punctures.A rise in blood glucose concentrations was observed after epinephrine injection in all groups, with no differences between them. SpeculationThese results suggest that in certain instances failure of endogenous epinephrine release may play a role in spontaneous hypoglycemia of the newborn. A major unresolved question is whether this failure of epinephrine release is itself primary, or whether asymptomatic hypoglycemia is not a sufficient stimulus for adrenal activation in these children.

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Thyroidal Radioiodine Uptake Rate Measurement in Infants

Fisher¹

1962

Arch Pediatr Adolesc Med

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Effect of Posture and Insulin Hypoglycemia on Catecholamine Excretion in the Newborn¹

Cited by 36 publications

References 14 publications

The Role of the Adrenal Medulla in the Hypoglycemia of Foetal Malnutrition

The Role of the Adrenal Medulla in the Hypoglycemia of Foetal Malnutrition

Catecholamine Excretion in Spontaneously Occurring Asymptomatic Neonatal Hypoglycemia

Thyroidal Radioiodine Uptake Rate Measurement in Infants

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Effect of Posture and Insulin Hypoglycemia on Catecholamine Excretion in the Newborn1

Cited by 36 publications

References 14 publications

The Role of the Adrenal Medulla in the Hypoglycemia of Foetal Malnutrition

The Role of the Adrenal Medulla in the Hypoglycemia of Foetal Malnutrition

Catecholamine Excretion in Spontaneously Occurring Asymptomatic Neonatal Hypoglycemia

Thyroidal Radioiodine Uptake Rate Measurement in Infants

Contact Info

Product

Resources

About

Effect of Posture and Insulin Hypoglycemia on Catecholamine Excretion in the Newborn¹