Effect of potassium channel openers on intraocular pressure in rabbits

Kaushal, Jyoti; Gupta, Manish Kumar; Goyal, Sarita; Verma, Savita

doi:10.4103/0253-7613.81486

Cited by 1 publication

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“…However, Melena et al 16 results did not support this hypothesis because a decrease in IOP was noted even at very high concentrations of diltiazem; furthermore, and in agreement to results of the present study, Melena et al 16 have not found a clear bilateral effect of diltiazem when administered to only one eye. Suggesting that diltiazem and other CCBs lack a contralateral effect in betamethasone induced rise in IOP in rabbits, and this agreed with Jani et al 23 who found that not clear bilateral effect of verapamil and diltiazem when administered to only one eye, suggesting that these CCBs lack a contralateral effect in these animal models for glaucoma. Appeared in contrast to those of Segarra et al 24 who found an IOP reduction, although not dose-related, in the contralateral eye after unilateral topical application of verapamil and diltiazem in albino rabbits.…”

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confidence: 85%

Effect of Diltiazem on Intraocular Pressure in Normal and Ocular Hypertensive Rabbits

A. Abdul-Hussein,

A. Alzubaidy,

A. Radi

2017

Qad Med J

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Background; Glaucoma is a multifactorial disease involving progressive optic neuropathy and altered intraocular hemodynamics; furthermore, glaucoma can cause blindness if it is left untreated.Aim of the study: To explore effects of topical diltiazem on intraocular pressure (IOP) in each of normal and ocular hypertensive rabbits.Materials and methods: A group of 54 males of the rabbits were included in the present study. Induction of ocular hypertension was achieved by injection of hydroxy propyl methylcellulose in the anterior chamber of rabbits right eye. In addition to distilled water (as negative control), each of timolol (as positive control) and diltiazem (the tested drug) eye drops were instilled 3 times daily to right eye prophylactically for 4 days and therapeuticallyResults: Part Î™: Diltiazem (0.5%) caused highly significant (P < 0.01) reduction in intraocular pressure of right eye . Part Î™Î™: diltiazem, at both concentrations (0.5% and 0.25%) caused highly significant reduction (P < 0.01) in IOP at 5th and 10th days post treatment.Conclusions: Diltiazem exerted a detectable ocular hypotensive effect on the eye of rabbits when applied at concentration (0.5%) or (0.25%) 3 times daily.

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