Effect of potassium supplementation on renal tubular function, ambulatory blood pressure and pulse wave velocity in healthy humans

Matthesen, Solveig Klok; Larsen, Thomas; Vase, Henrik; Lauridsen, Thomas Guldager; Pedersen, E. B.

doi:10.3109/00365513.2011.635216

Cited by 43 publications

(38 citation statements)

References 37 publications

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“…Several studies have investigated the effect of a dietary potassium increase on vascular function as assessed by augmentation index. Findings consistently show no change in AI, following potassium supplementation [28,29,54].…”

Section: Potassium and Vascular Functionmentioning

confidence: 84%

“…However Berry et al [28] found no change in PWV following increases of 20 mmol/d and 40 mmol/d of potassium from fruit and vegetables or a 40 mmol/d potassium citrate supplement when compared to placebo. In contrast, Matthesen et al [54] found a moderate deterioration in PWV following four weeks of 100 mmol/d potassium chloride supplementation. However this increase was accompanied by an increase in plasma aldosterone which has previously been directly associated with increases in PWV [55].…”

Section: Potassium and Vascular Functionmentioning

confidence: 90%

“…We have recently shown that an increase in dietary potassium (48 mmol) from bananas and potatoes significantly reduced serum E-selectin [26]. In contrast in a study with a high dose of daily potassium supplementation (100 mmol/ d) which increased plasma aldosterone there were no chanced in ET-1 [54]. Whereas a 60 mmol potassium dose attenuated a sodium induced increased in ET-1 [11].…”

Section: Potassium and Biochemical Markers Of Endothelial Dysfunctionmentioning

confidence: 96%

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A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

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Clifton

Keogh

2015

Nutrition, Metabolism and Cardiovascular Diseases

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Section: Potassium and Vascular Functionmentioning

confidence: 84%

Section: Potassium and Vascular Functionmentioning

confidence: 90%

Section: Potassium and Biochemical Markers Of Endothelial Dysfunctionmentioning

confidence: 96%

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A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

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Clifton

Keogh

2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…Our study showed no meal 3 time interaction for AIx. Previous studies showed no effect of potassium interventions on fasting AIx (15,39,40). One salt-substitution study (simultaneously reducing sodium and increasing potassium) showed significant improvements in measures of arterial stiffness (central pulse pressure and pulse wave reflection time) after 12 mo of intervention but did not see an effect on AIx (41).…”

Section: Discussionmentioning

confidence: 98%

Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

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Clifton

Petersen

et al. 2015

The American Journal of Clinical Nutrition

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Background: It is known that increased potassium and reduced sodium intakes can improve postprandial endothelial function. However, the effect of increasing potassium in the presence of high sodium in the postprandial state is not known. Objective: We aimed to determine the effect of high potassium and high sodium on postprandial endothelial function as assessed by using flow-mediated dilatation (FMD) and arterial compliance as assessed by using pulse wave velocity (PWV) and central augmentation index (AIx). Design: Thirty-nine healthy, normotensive volunteers [21 women and 18 men; mean 6 SD age: 37 6 15 y; BMI (in kg/m 2 ): 23.0 6 2.8] received a meal with 3 mmol K and 65 mmol Na (low-potassium, high-sodium meal (LKHN)], a meal with 38 mmol K and 65 mmol Na [high-potassium, high-sodium meal (HKHN)], and a control meal with 3 mmol K and 6 mmol Na (low-potassium, low-sodium meal) on 3 separate occasions in a randomized crossover trial. Brachial artery FMD, carotid-femoral PWV, central AIx, and blood pressure (BP) were measured while participants were fasting and at 30, 60, 90, and 120 min after meals. Results: Compared with the LKHN, the addition of potassium (HKHN) significantly attenuated the postmeal decrease in FMD (P-meal by time interaction , 0.05). FMD was significantly lower after the LKHN than after the HKHN at 30 min (P , 0.01). AIx decreased after all meals (P , 0.05). There were no significant differences in AIx, PWV, or BP between treatments over time. Conclusion: The addition of potassium to a high-sodium meal attenuates the sodium-induced postmeal reduction in endothelial function as assessed by FMD. This trial was registered at

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“…17 Limited studies have examined the effects of sodium or potassium on measures of arterial stiffness, with inconclusive results both for sodium [18][19][20][21][22][23][24][25] and potassium. [26][27][28][29] We performed a randomised, placebo-controlled, crossover study to examine the effects of sodium and potassium supplementation on office BP, ambulatory BP and arterial stiffness in Dutch subjects with untreated elevated BP. Supplementation took place while subjects were on a fully controlled diet that was relatively low in sodium and potassium, with all meals provided during the study.…”

Section: Introductionmentioning

confidence: 99%

Effects of sodium and potassium supplementation on blood pressure and arterial stiffness: a fully controlled dietary intervention study

et al. 2015

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We performed a randomised, placebo-controlled, crossover study to examine the effects of sodium and potassium supplementation on blood pressure (BP) and arterial stiffness in untreated (pre)hypertensive individuals. During the study, subjects were on a fully controlled diet that was relatively low in sodium and potassium. After a 1-week run-in period, subjects received capsules with supplemental sodium (3 g d(-1), equals 7.6 g d(-1) of salt), supplemental potassium (3 g d(-1)) or placebo, for 4 weeks each, in random order. Fasting office BP, 24-h ambulatory BP and measures of arterial stiffness were assessed at baseline and every 4 weeks. Of 37 randomized subjects, 36 completed the study. They had a mean pre-treatment BP of 145/81 mm Hg and 69% had systolic BP ⩾140 mm Hg. Sodium excretion was increased by 98 mmol per 24 h and potassium excretion by 63 mmol per 24 h during active interventions, compared with placebo. During sodium supplementation, office BP was significantly increased by 7.5/3.3 mm Hg, 24-h BP by 7.5/2.7 mm Hg and central BP by 8.5/3.6 mm Hg. During potassium supplementation, 24-h BP was significantly reduced by 3.9/1.6 mm Hg and central pulse pressure by 2.9 mm Hg. Pulse wave velocity and augmentation index were not significantly affected by sodium or potassium supplementation. In conclusion, increasing the intake of sodium caused a substantial increase in BP in subjects with untreated elevated BP. Increased potassium intake, on top of a relatively low-sodium diet, had a beneficial effect on BP. Arterial stiffness did not materially change during 4-week interventions with sodium or potassium.

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Effect of potassium supplementation on renal tubular function, ambulatory blood pressure and pulse wave velocity in healthy humans

Abstract: Potassium supplementation changed renal tubular function and increased water absorption in the distal part of the nephron. In spite of an increase in aldosterone in plasma, blood pressure remained unchanged after potassium supplementation.

Cited by 43 publications

References 37 publications

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

Effects of sodium and potassium supplementation on blood pressure and arterial stiffness: a fully controlled dietary intervention study

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