Effect of Pre- and postweaning nutrition on dietary induced obesity in B6D2F2 mice

Wainwright, P.E.; Francey, Carolyn

doi:10.1016/0031-9384(87)90134-x

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…Additional environmental and perhaps stochastic developmental influences must play a role. For example, as observed in other studies (41,63), we have found a significant influence of litter size on body weight and fat accumulation, presumably due to preweaning food competition in large litters. Such influences of early nutrition on adult body weight appear to be specific for some genetic backgrounds, such as tabw2, because an effect of litter size on measures of adiposity has not been observed in an intercross population of (LG/J ϫ SM/J) F2 mice (23).…”

Section: Discussionsupporting

confidence: 89%

Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity

Kim

Stewart

Zhang

et al. 2005

Physiological Genomics

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The TallyHo (TH) mouse strain is a polygenic model for Type 2 diabetes with obesity. Genetic analysis in backcross progeny from a cross between F1 [C57BL/6J (B6) x TH] and TH mice mapped a quantitative trait locus (QTL) named TH-associated body weight 2 (tabw2) to chromosome 6. The TH-derived allele is associated with increased body weight. As a first step to identify the molecular basis of this obesity QTL, we constructed a congenic line of mice on the B6 genetic background that carries a genomic region from TH mice containing tabw2. Congenic mice homozygous for tabw2 (B6.TH-tabw2/tabw2) fed a chow diet exhibited slightly, but significantly, higher body weight and body fat and plasma leptin levels compared with controls (B6.TH-+/+). This difference was exacerbated when the animals were maintained on a high-fat and high-sucrose (HFS) diet. The diet-induced obesity in tabw2 congenic mice is accompanied by hyperleptinemia, mild hyperinsulinemia, impaired glucose tolerance, and reduced glucose uptake in adipose tissue in response to insulin administration. Using F2 progeny fed a HFS diet from an intercross of B6.TH-tabw2/+ mice, we were able to refine the map position of the tabw2 obesity susceptibility locus to a 15-cM region (95% confidence interval) extending distally from the marker D6Mit102. In summary, tabw2 congenic mice are a new animal model for diet-induced obesity that will be valuable for the study of gene-diet interactions.

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Section: Discussionsupporting

confidence: 89%

Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity

Kim

Stewart

Zhang

et al. 2005

Physiological Genomics

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“…Certainly the effect on behavioral development of rearing in litters of 12 compared with litters of 8 (0.2 days) was small relative to previous work which showed an effect of prenatal protein malnutrition of 1.4 days (Wainwright & Russell, 1983). However, in support of the present data, there were large effects on overall growth, and recent work in our laboratory (Wainwright & Francey, 1987) has shown permanent deficits in adult body weight in this population of mice consequent on rearing in litters of 12, suggesting that they were indeed undernourished. It is also important to recognize that there may be behavioral measures other than those used here which are more sensitive to nutritional effects, and this should be addressed in future research.…”

Section: Discussionsupporting

confidence: 64%

The quantitative relationship between nutritional effects on preweaning growth and behavioral development in mice

Wainwright

Pelkman

Wahłsten

1989

Developmental Psychobiology

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Our objective was to establish whether nutritional effects on the behavioral development of preweaning mouse pups were linearly related to effects on body and brain growth or whether there was a threshold effect, with behavior being affected only by nutritional extremes. We also used a standardized scale of development to compare the relative magnitude of such effects on morphological and behavioral measures. The level of nutrient availability was manipulated continuously by rearing the pups in litter sizes ranging from 3 to 12. On Day 32 post-conception, measures were taken of body weight, brain weight, thickness of the cerebellar external granular layer (EGL), and behavioral development. The relationship between litter size and body weight, brain weight, and behavioral development was best described by a linear regression model; no threshold effect was apparent. By comparing measures on animals from different litter sizes at the same age (32 days) to standard developmental curves over a wide range of ages, we found that for every additional pup in a litter, body growth was retarded by the equivalent of 1.28 days, brain weight by 0.44 day, and behavioral development by 0.07 day. Although the variation in nutrient availability provided by this range of litter sizes does result in a linear relationship between growth and behavioral development, there is nevertheless considerable sparing of function.

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Effects of preweaning nutrition on weight gain during pregnancy in mice

Wainwright

McCutcheon

1988

Physiology & Behavior

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Effect of Pre- and postweaning nutrition on dietary induced obesity in B6D2F2 mice

Cited by 7 publications

References 9 publications

Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity

Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity

The quantitative relationship between nutritional effects on preweaning growth and behavioral development in mice

Effects of preweaning nutrition on weight gain during pregnancy in mice

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