Effect of pre-consultation testing on clinicians’ adherence to malaria test results and waiting time among children under 5 years in the Northern Zone of Volta Region of Ghana

Gmanyami, Jonathan Mawutor; Ameko, Asiwome; Ahiafe, Saviour Selase; Bosoka, Samuel Adolf; Kweku, Margaret; Ansah, Evelyn

doi:10.1186/s12936-020-03189-6

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…Therefore, efforts should be made to ensure adequate logistics and human resources to implement the guideline effectively and efficiently, and motivate positive health-seeking behavior among patients. An innovation such as pre-consultation testing has been shown to increase adherence to testing and treatment and reduced the time mothers of children spend at the OPD [ 28 ]. Both prescribers and caregivers of children preferred the pre-consultation testing to the usual consultation practice before laboratory testing [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Challenges with adherence to the ‘test, treat, and track’ malaria case management guideline among prescribers in Ghana

Kolekang

Afrane

Apanga

et al. 2022

Malar J

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Background Despite several efforts at addressing the barriers to adherence to the WHO-supported test, treat and track (T3) malaria case management guideline in Ghana, adherence remains a challenge. This study explored the challenges of prescribers regarding adherence to the T3 guideline. Methods This was an explorative study using key informant interviews amongst prescribers comprising medical doctors, physician assistants, nurses and a health extension worker from 16 health facilities in six districts in Ghana. The data was analysed using Nvivo 10 and organized into thematic areas. Results Prescribers lauded the guideline on testing and treatment as it ensures the quality of malaria case management, but irregular supply of malaria rapid diagnostic test kits (RDT), mistrust of laboratory tests, and the reluctance of prescribers to change from presumptive treatment were key barriers to testing. Patients with malaria test negative results if not treated, revisiting the facility with severe malaria, the experience of prescribers, lack of regular training and supervision for old and new staff and the inability of prescribers to investigate non-malaria fever hindered adherence to results-based treatment. Conclusion As malaria remains a significant cause of morbidity and mortality in Ghana, this study provides insights on gaps in adherence to the testing and treatment of malaria. While the diagnostic capacity for malaria case management is a challenge, the lack of training resulting in the inability of some prescribers to investigate non-malaria fever hinders adherence to the malaria case management guideline. Therefore, there is a need to train new prescribers, laboratory personnel, and other staff involved in malaria diagnosis and treatment on the malaria case management guideline before they assume duty. Equipping laboratory personnel and prescribers with the knowledge to investigate non-malaria fevers could improve adherence to the guideline for improved patient care.

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Section: Discussionmentioning

confidence: 99%

“…An innovation such as pre-consultation testing has been shown to increase adherence to testing and treatment and reduced the time mothers of children spend at the OPD [ 28 ]. Both prescribers and caregivers of children preferred the pre-consultation testing to the usual consultation practice before laboratory testing [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Challenges with adherence to the ‘test, treat, and track’ malaria case management guideline among prescribers in Ghana

Kolekang

Afrane

Apanga

et al. 2022

Malar J

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“…Malaria RDTs allow reductions in turnaround times in larger health facilities with laboratories, especially in high burden malaria regions, where a combination of patient load and inadequate staffing levels for microscopy can sometimes overwhelm laboratories. 16 In some countries, outpatient nurses are able to test suspected malaria patients using RDTs before patients seeclinicians. 16 Even when microscopes are available, inadequate support for items such as reagents, supplies, equipment maintenance, and training to provide consistent high-quality testing make RDTs a better choice for malaria diagnosis in some settings.…”

Section: Rdt Use In the Formal Public Health Sectormentioning

confidence: 99%

“…16 In some countries, outpatient nurses are able to test suspected malaria patients using RDTs before patients seeclinicians. 16 Even when microscopes are available, inadequate support for items such as reagents, supplies, equipment maintenance, and training to provide consistent high-quality testing make RDTs a better choice for malaria diagnosis in some settings.…”

Section: Rdt Use In the Formal Public Health Sectormentioning

confidence: 99%

Ten Years of Universal Testing: How the Rapid Diagnostic Test Became a Game Changer for Malaria Case Management and Improved Disease Reporting

Aidoo

Incardona

2022

The American Journal of Tropical Medicine and Hygiene

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In 2010, the World Health Organization changed its guidance on malaria case management, recommending parasitological confirmation of all suspected cases before treatment with an antimalarial. This recommendation was in large part as a result of the availability of quality assured malaria rapid diagnostic tests (RDTs) that made it possible for malaria diagnosis to be performed by laboratory staff in all health facilities irrespective of the facility’s place in the tiered health system. Community health workers and other non-laboratory health workers who traditionally did not perform malaria testing due to the technical and logistic demands of smear microscopy were now able to test for malaria. The use of RDTs has led to substantial increases in testing rates, improved quality of case management, as well as more accurate reporting of malaria cases. Although current RDTs have limitations, they remain one of the most important tools in contemporary malaria control. Further improvements to existing products, such as increased sensitivity for non-falciparum tests, diversification of Plasmodium falciparum antigen targets, along with strengthened health system support for current RDTs will further enhance their utility in malaria control and prevention.

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“…However, malaria cases have steadily risen in Africa since 2014 due to drug resistance in parasitic strains [2]. Among the five species, P. falciparum and P. vivax are the two greatest contributors for malaria and highest mortality rate to human, two species that have been confirmed to have developed a resistance to current antimalarial drugs [3]. Currently, Plasmodium vivax is the most prevalent and the cause of most malaria-related deaths across Sub-Saharan Africa.…”

Section: Introductionmentioning

confidence: 99%

Structure-Based Virtual Screening, Insilico Docking, ADME Prediction, and Molecular Dynamics Studies for Identification of Potential NMT Inhibitors Against Malaria

Anbuselvam¹,

Katherine

Anbuselvam

et al. 2021

Preprint

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One of the major public health problems globally, malaria, is mainly caused protozoan parasites from the genus Plasmodium, and commonly spreads to people through the bites of infected female mosquitoes of the genus Anopheles. Strategies for treatment, prevention, and control are available for malaria but the eradication of malaria still poses great challenge due to plasmodium’s drug resistance over the past decades. Development of novel antimalarial drugs remains a significant task to protect people from malaria. N-Myristoyl transferase is responsible for the N-Myristoylation catalysis process and the survival of Plasmodium species. Thus, it is considered a therapeutic drug target in protozoans and was recently validated as a significant target for Plasmodium vivax. In this present scenario, we endeavour to identify effective NMT inhibitors to prevent the onset of malaria in the human species. Initially, the structure-based virtual screening was executed against ZINC database and four potential candidates for NMT were identified. Furthermore, the four identified compounds were subjected to ADME prediction and all the four compounds found within adequate range with predicted ADME properties. Eventually, we conducted the molecular dynamics simulation to investigate the binding stability of top three protein-ligand complexes at different time scale by employing the tool Desmond. The molecular dynamics simulation studies revealed the protein-ligand complexes were stable throughout the entire simulation. Besides, we noticed that the residues ASN 365, PHE 103 and HIS 213 of NMT were crucially involved in the formation of various intermolecular interactions, significantly contributing to the stability of protein-ligand complexes. From this computational investigation, we suggest that the three identified potential compounds are extremely useful for further lead optimization and drug development.

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Effect of pre-consultation testing on clinicians’ adherence to malaria test results and waiting time among children under 5 years in the Northern Zone of Volta Region of Ghana

Cited by 8 publications

References 18 publications

Challenges with adherence to the ‘test, treat, and track’ malaria case management guideline among prescribers in Ghana

Challenges with adherence to the ‘test, treat, and track’ malaria case management guideline among prescribers in Ghana

Ten Years of Universal Testing: How the Rapid Diagnostic Test Became a Game Changer for Malaria Case Management and Improved Disease Reporting

Structure-Based Virtual Screening, Insilico Docking, ADME Prediction, and Molecular Dynamics Studies for Identification of Potential NMT Inhibitors Against Malaria

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