Effect of Pre-Enucleation Irradiation on the Survival of Patients with Uveal Melanoma

Günalp, İlhan; Batıoğlu, Figen

doi:10.1159/000027298

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…Among our 136 patients there were 64 men and 72 women, aged between 20 and 92 years, mean age of 61.7 years being in conformity with the mean age between 44.8 and 65 years reported in other studies [14, 15, 20, 21], whereas the mean age for patients with cutaneous melanoma is usually lower with a nearly equal sex distribution [14, 19]. …”

Section: Discussionsupporting

confidence: 88%

Ocular Melanoma: Epidemiology, Clinical Presentation and Relationship with Dysplastic Nevi

Richtig

Langmann²,

Müllner³

et al. 2004

Ophthalmologica

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Purpose: Ocular melanoma is a rare entity compared to cutaneous malignant melanoma. We examined the frequency of the tumor in a defined geographic region, its clinical presentation and its relationship with dysplastic nevi in 136 patients. Methods: 136 patients (64 men and 72 women; mean age 61.7 years, range 20–92 years) with ocular melanoma were treated at the University Hospital of Graz between June 1996 and December 2001. 129 had primary uveal melanoma in one eye (117 choroidal melanomas, 11 melanomas of the ciliary body and 1 of the iris), 2 patients had uveal melanoma in both eyes, 4 patients had conjunctival melanoma and 1 patient had a melanoma of the lacrimal sac. Epidemiology, history, potential risk factors, clinical presentation and relationship with dysplastic (= atypical) nevi were documented. Results: 48 patients (35.3%) showed more than five dysplastic nevi, compared to only 1.2% in the general population (χ² test: p < 0.001). 5 (3.7%) had additional cutaneous melanoma and 7 (5.1%) had a family history of melanoma. The lifelong risk for the occurrence of an additional primary cutaneous melanoma was 2.9%, which is significantly higher than the usual estimate of 1% for the general population. Conclusions: Patients with primary ocular melanoma have an increased risk to develop cutaneous melanoma and should therefore be examined regularly by dermatologists.

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Section: Discussionsupporting

confidence: 88%

Ocular Melanoma: Epidemiology, Clinical Presentation and Relationship with Dysplastic Nevi

Richtig

Langmann²,

Müllner³

et al. 2004

Ophthalmologica

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“…9,21,22 Preenucleation radiotherapy did not decrease the number of short-term melanoma-related deaths. 12,15,23 Likewise, no beneficial effect of PER on survival was found in an uncontrolled prospective study of 80 patients with primary choroidal and ciliary body melanoma 12 or in an uncontrolled retrospective study of 26 patients with choroidal melanoma. 11 Moreover, preoperative radiation with 5 fractions of 400 rad (4 Gy) had a worse prognosis in a series of 41 nonrandomly selected patients.…”

Section: Commentmentioning

confidence: 99%

“…[5][6][7][8][9] However, clinical application of PER has been abandoned, because no significant difference in survival could be demonstrated between PER and enucleation only (EO) groups. [10][11][12][13][14][15][16] The mean follow-up time in these clinical studies ranged from 5 to 8 years. Based on theoretical models, clini-cally manifest metastases are likely to occur 5 or 6 years after onset of the systemic dissemination.…”

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confidence: 99%

Reduced Melanoma-Related Mortality in Uveal Melanoma by Preenucleation Radiotherapy

Kılıç

Stijnen²,

Jong³

et al. 2005

Arch Ophthalmol

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Background: Radiotherapy of an eye before enucleation, so called preenucleation radiotherapy (PER), of patients with uveal melanoma was initiated to reduce enucleation-induced systemic metastasis. Earlier studies with a short follow-up period have not demonstrated a significant effect on survival. Objective: To study the effect of PER on melanomarelated mortality after more than 9 years of follow-up. Design: In a prospective study, 167 patients with uveal melanoma were treated between 1978 and 1992 by irradiation with 800 rad (8 Gy) given in 2 fractions 2 days before enucleation. A group of 108 patients with uveal melanoma treated between 1971 and 1992 by enucleation only in the same hospital served as a historical control group. Patients were followed up until December 2002 or death. Results: Melanoma-related death occurred in 32.3% of the PER-treated group and in 40.7% of the enucleation only group. Mean follow-up was 9.25 years. After 48 months of follow-up, a significant difference in survival became evident in favor of the PER group. The estimated 15-year survival rates for patients with melanoma in the PER group and enucleation only group were 63.7% and 51.0%, respectively. For patients dying of all causes, these percentages were 47.5% and 25.2%, respectively. In both groups, women had a better prognostic outcome than men. Conclusion: This study suggests that PER improves longterm survival in patients with uveal melanoma.

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Radioterapia preoperatoria en el melanoma de coroides con afectación extraescleral

Segundo¹,

Alvarez²,

Meteos³

et al. 2002

Rev Oncol

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Effect of Pre-Enucleation Irradiation on the Survival of Patients with Uveal Melanoma

Cited by 8 publications

References 21 publications

Ocular Melanoma: Epidemiology, Clinical Presentation and Relationship with Dysplastic Nevi

Ocular Melanoma: Epidemiology, Clinical Presentation and Relationship with Dysplastic Nevi

Reduced Melanoma-Related Mortality in Uveal Melanoma by Preenucleation Radiotherapy

Radioterapia preoperatoria en el melanoma de coroides con afectación extraescleral

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