This paper presents the design and analysis of a conditioning circuit for Metal-Oxide Semiconductor (MOS) gas sensors within an electronic nose system. By effectively addressing the challenges of signal amplification, filtering, and stabilization, the proposed circuit enhances the reliability and accuracy of gas detection. The system architecture, which includes temperature control and signal modulation, is optimized for precise Odor identification in various applications, ranging from industrial safety to healthcare diagnostics. Simulation results demonstrate the circuit’s ability to improve sensor performance, ensuring accurate and reproducible measurements.