Effect of Pre-pregnancy Maternal Body Mass Index on Obstetric Outcomes in a Tertiary Care Hospital in Goa, India

Naik, Rini; Karmali, Deepa; Nagarsenkar, Ajit; Mainath, Sneha; Pednekar, Guruprasad

doi:10.1007/s13224-021-01565-z

Cited by 3 publications

(4 citation statements)

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“…The sample size of our study was more extensive, which strengthened the credibility of the evidence. Similar findings have been found in Italian, Indian and Japanese populations 47–49. The pathogenesis of maternal pre-pregnancy overweight/obesity and pre-eclampsia and GDM during pregnancy is complex and not yet fully understood.…”

Section: Discussionsupporting

confidence: 85%

Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China

Sun

Luo

Wang

et al. 2023

BMJ Open Diab Res Care

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IntroductionTo investigate the independent and combined effects of advanced maternal age and pre-pregnancy body mass index (BMI) on the risk of pre-eclampsia and gestational diabetes mellitus (GDM).Research design and methodsLogistic regression models were used to estimate the OR and 95% CIs of pre-eclampsia and GDM with advanced maternal age and pre-pregnancy BMI, respectively, and the interaction between advanced maternal age and pre-pregnancy BMI. We also used causal mediation analysis to assess the mediating role of pre-pregnancy BMI on maternal age–pre-eclampsia/GDM associations.ResultsIn this study, 788 cases (2.31%) were diagnosed with pre-eclampsia and 5430 cases (15.92%) were diagnosed with GDM. We found that advanced maternal age was associated with a higher risk for pre-eclampsia and GDM, with adjusted ORs (aORs) of 1.74 (95% CI 1.49–2.05) and 1.76 (95% CI 1.65–1.89) after adjusting for potential confounders, respectively. In addition, maternal pre-pregnancy overweight/obesity was associated with the risk of pre-eclampsia and GDM, with the corresponding aORs of 3.64 (95% CI 3.12–4.24) and 1.71 (95% CI 1.60–1.85), respectively. We also observed the interaction between maternal age and pre-pregnancy BMI for the risk of pre-eclampsia/GDM (all p for interaction <0.001). In the mediating effect analysis, we found that maternal pre-pregnancy BMI mediated the associations between maternal age and the development of pre-eclampsia and GDM.ConclusionsAdvanced maternal age and pre-pregnancy BMI were respectively associated with the risk of pre-eclampsia/GDM, and there was an interaction between the two risk factors. In addition, we found that pre-pregnancy BMI served as a mediator of the association between advanced maternal age and the risk of pre-eclampsia/GDM, providing an essential target for the prevention of maternal overweight/obesity.

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Section: Discussionsupporting

confidence: 85%

Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China

Sun

Luo

Wang

et al. 2023

BMJ Open Diab Res Care

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“…In India, a large cohort study of pregnant women showed that the prevalence of anemia was significantly higher (32.1%) in the women with underweight compared with the prevalence of anemia in women with normal weight (4.2%) and with obesity (3.9%) [ 26 ]. Likewise, in Nepal, in 609 pregnant women, anemia was associated with a low BMI (AOR) [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several factors such as age and educational level are associated with obesity during pregnancy [ 17 ]. Previous studies have shown different levels of association between BMI and obesity and anemia or hemoglobin levels among pregnant women [ 16 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. While some studies have shown that hemoglobin levels were significantly higher among pregnant women with obesity [ 18 , 27 ] or that pregnant women with obesity were less likely to have anemia [ 22 , 23 , 28 ], other studies have shown that hemoglobin levels were significantly lower in women with obesity [ 29 ] and that obese pregnant women were at higher risk for anemia [ 16 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…While some studies have shown that hemoglobin levels were significantly higher among pregnant women with obesity [ 18 , 27 ] or that pregnant women with obesity were less likely to have anemia [ 22 , 23 , 28 ], other studies have shown that hemoglobin levels were significantly lower in women with obesity [ 29 ] and that obese pregnant women were at higher risk for anemia [ 16 , 24 ]. Some studies have shown no association between BMI and anemia among pregnant women [ 19 , 20 , 21 ], while other studies have shown that a lower BMI was associated with anemia [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Hemoglobin Levels, Anemia, and Their Associations with Body Mass Index among Pregnant Women in Hail Maternity Hospital, Saudi Arabia: A Cross-Sectional Study

et al. 2023

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The level of association between hemoglobin level/anemia and obesity during pregnancy is not yet fully understood. A cross-sectional study was conducted in Hail Maternity Hospital in northern Saudi Arabia from March to May 2023 to assess the associations between hemoglobin levels, anemia, and obesity among pregnant women. Reproductive history was gathered through a questionnaire. Body mass index (BMI) was calculated/computed from the women’s weight and height. Linear and binary regression analyses were performed. A total of 334 pregnant women were enrolled. The median (interquartile range (IQR)) age and parity were 33.2 (27.4–37.8) years and 3 (1–5), respectively. Of the 334 women, 52 (15.6%) were normal weight, while 87 (26.0%) were overweight and 195 (58.4%) were obese. In the multiple linear regression, parity (coefficient = −0.121, p = 0.001) and BMI (coefficient = 0.030, p = 0.006) were negatively associated with the hemoglobin level. Ninety-nine (26.9%) women had anemia. In the multivariate analysis, primiparity (adjusted odds ratio (AOR) = 0.54, 95% confidence interval (CI) = 0.30–0.97), increasing BMI (AOR = 0.93, 95% CI = 0.89–0.97), and obesity (AOR = 0.31, 95% CI = 0.16–0.61) were associated with decreased ORs of anemia. Increasing parity was associated with increased ORs of anemia (AOR = 1.18, 95% CI = 1.05–1.32). Being overweight was not associated with anemia (AOR = 0.56, 95% CI = 0.27–1.16). In the current study, a high hemoglobin level and lower prevalence of anemia were observed among obese pregnant women.

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Exploring the Impact of Prepregnancy Body Mass Index on Obstetric Outcomes: A Comprehensive Review

Vijay,

Dahifale

2024

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aim: Because pregnancy-related changes in a woman's body mass index (BMI) have a major impact on maternal and newborn health outcomes, these alterations have become a focus of attention in the fields of obstetrics and maternal-fetal medicine. We seek to clarify the complex relationships between prepregnancy BMI and perinatal outcomes, fetal health, and maternal health by critically analyzing and synthesizing a wide range of research findings. Materials and methods: A thorough search of the literature was part of our approach, and we used academic databases like PubMed, MEDLINE, Embase, Scopus, and Web of Science. We used a mix of pertinent MeSH terms and keywords associated with prepregnancy BMI and obstetric outcomes. We considered research that looked into the relationship between prepregnancy BMI and different obstetric outcomes, and that was published between 2020 and the present. Excluded studies did not have precise prepregnancy BMI-related outcomes or peer-reviewed validation. Prepregnancy BMI categories, obstetric outcomes, participant characteristics, sample size, and study design were all covered by the identical form used for data extraction. Using the proper instruments, a quality evaluation was carried out, assessing the study design, sample representativeness, exposure measurement, and result ascertainment. Results: Our thorough investigation shows that prenatal BMI has a significant impact on the health of both the mother and the fetus. Underweight women have an increased risk of preterm births, low birth weight babies, and inadequate gestational weight gain. On the other hand, women who are overweight or obese are more likely to experience adverse outcomes such as gestational diabetes, preeclampsia, macrosomia, and excessive prenatal weight gain. These results highlight the significance of encouraging a healthy pre-conception weight to improve obstetric outcomes and highlight the crucial role that prepregnancy BMI plays in prenatal care and risk assessment. Conclusion: This review highlights the need for targeted healthcare programs to reduce the negative effects of obesity and encourage healthier pregnancies, offering insightful information to researchers, politicians, and healthcare practitioners. The results support evidence-based practice and worldwide improvements in maternal and newborn health, making a valuable contribution to the continuing evolution of maternal-fetal medicine.

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Effect of Pre-pregnancy Maternal Body Mass Index on Obstetric Outcomes in a Tertiary Care Hospital in Goa, India

Cited by 3 publications

References 4 publications

Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China

Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China

Hemoglobin Levels, Anemia, and Their Associations with Body Mass Index among Pregnant Women in Hail Maternity Hospital, Saudi Arabia: A Cross-Sectional Study

Exploring the Impact of Prepregnancy Body Mass Index on Obstetric Outcomes: A Comprehensive Review

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