Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes

Akbulut, Sami; Barut, Bora; Garzali, Ibrahım Umar; Sarici, Kemal Baris; Tamer, M. Akram; Unsal, Selver; Karabulut, Ertuğrul; Başkıran, Adil; Bayındır, Yaşar; Yilmaz, Sezai

doi:10.1016/j.transproceed.2023.01.024

Cited by 1 publication

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…61 Some reports indicated that young female patients with LT have a better prognosis, which may be related to estrogen. 62,63 After LT, some individuals went through stress responses, including hypertension, renal metabolic dysfunction, and hyperlipidemia, elevated the probability of SARS-CoV-2 infection. 60,64 Immunosuppressive agents are necessary to prevent allogeneic organ transplant rejection in LT patients while increase the likelihood of opportunistic infections in them.…”

Section: Acetaminophenmentioning

confidence: 99%

“…ELITA/ELTR Multi‐center European Study have indicated that age older than 70 had a negative impact on LT patients infected with SARS‐CoV‐2 61 . Some reports indicated that young female patients with LT have a better prognosis, which may be related to estrogen 62,63 . After LT, some individuals went through stress responses, including hypertension, renal metabolic dysfunction, and hyperlipidemia, elevated the probability of SARS‐CoV‐2 infection 60,64 .…”

Section: Influence Of Liver Disease To Covid‐19mentioning

confidence: 99%

See 1 more Smart Citation

COVID‐19‐associated liver injury: Adding fuel to the flame

Wang,

Shen,

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

COVID‐19 is mainly characterized by respiratory disorders and progresses to multiple organ involvement in severe cases. With expansion of COVID‐19 and SARS‐CoV‐2 research, correlative liver injury has been revealed. It is speculated that COVID‐19 patients exhibited abnormal liver function, as previously observed in the SARS and MERS pandemics. Furthermore, patients with underlying diseases such as chronic liver disease are more susceptible to SARS‐CoV‐2 and indicate a poor prognosis accompanied by respiratory symptoms, systemic inflammation, or metabolic diseases. Therefore, COVID‐19 has the potential to impair liver function, while individuals with preexisting liver disease suffer from much worse infected conditions. COVID‐19 related liver injury may be owing to direct cytopathic effect, immune dysfunction, gut−liver axis interaction, and inappropriate medication use. However, discussions on these issues are infancy. Expanding research have revealed that angiotensin converting enzyme 2 (ACE2) expression mediated the combination of virus and target cells, iron metabolism participated in the virus life cycle and the fate of target cells, and amino acid metabolism regulated immune response in the host cells, which are all closely related to liver health. Further exploration holds great significance in elucidating the pathogenesis, facilitating drug development, and advancing clinical treatment of COVID‐19‐related liver injury. This article provides a review of the clinical and laboratory hepatic characteristics in COVID‐19 patients, describes the etiology and impact of liver injury, and discusses potential pathophysiological mechanisms.

show abstract