Effect of pre-treatment of melatonin on superovulation response, circulatory hormones, and miRNAs in goats during environmental heat stress conditions

Samir, Haney; Samir, Mohamed; Radwan, Faten; Mandour, Ahmed S.; El-Sherbiny, Hossam R.; Ahmed, Ahmed Ezzat; Al Syaad, Khalid M.; Al-Saeed, Fatimah A.; Watanabe, Gen

doi:10.1007/s11259-023-10239-2

Cited by 3 publications

(3 citation statements)

References 105 publications

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“…Melatonin is involved in regulating seasonal animal reproduction ( 20 , 32 ). In an environment with varying light intensity, MT secretion in the body also varied considerably ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats

Sun,

Lv,

Niu

et al. 2024

Front. Vet. Sci.

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In large-scale intensive farms, dairy goats often undergo frequent estrus synchronization (ES) treatment, which may result in a decline in reproductive performance; however, the underlying mechanism remains unclear. The present study aimed to investigate the effect of pregnant mare serum gonadotropin (PMSG) and progesterone (P4)-mediated ES treatment on fertility in dairy goats, while also identifying key metabolic and endocrine mechanisms that influence reproductive performance in does subjected to repeated ES treatment. Forty-eight Saanen does were randomly assigned to two groups (24 goats each) that received ES treatments either thrice fortnightly (3-PMSG) or once (1-PMSG) simultaneously with the third ES treatment of the 3-PMSG group during the breeding season. ES treatment was performed via the intravaginal insertion of a controlled internal drug release (CIDR) device impregnated with 300 mg P4, followed by 300 IU PMSG injections 48 h before CIDR withdrawal. Blood was collected to detect the level of hormones and blood biochemical indices. Additionally, estrus rate, fecundity rate, body weight, size, and lactation performance were measured. The results showed that repeated ES treatment markedly decreased the estrus rate and fecundity rate of goats. Among the does in all groups, there was no substantial difference in follicle stimulating hormone, luteinising hormone, gonadotropin-releasing hormone, melatonin, growth hormone, PMSG, total cholesterol, total protein, and glucose levels, as well as the body weight, body size, and lactation performance. Repeated ES treatment elevated estrogen (E2) levels 36, 48, and 72 h post-CIDR removal; increased P4 upon CIDR insertion; and raised PMSG antibody levels 24, 48, and 72 h post-CIDR removal. The results suggest that elevated anti-PMSG levels are the primary reason for the decline in ES efficiency, and that high E2 and P4 levels at some time points also impair reproductive performance. These findings provide novel insights into the metabolic effects of repeated PMSG stimulation in goats, guiding future reproductive hormone use in breeding practices.

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“…Melatonin is involved in regulating seasonal animal reproduction ( 20 , 32 ). In an environment with varying light intensity, MT secretion in the body also varied considerably ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats

Sun,

Lv,

Niu

et al. 2024

Front. Vet. Sci.

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“…Invasive techniques like laparotomies and electromagnetic probes were used in earlier studies to examine uterine blood flow (Sakamoto et al 1996 ). However, because Doppler ultrasonography allowed scientists and veterinarians to evaluate organ morphology and functions based on vascular perfusion (Lüttgenau and Bollwein 2014 ; El-Sherbiny et al 2022 ; Samir et al 2023a , b ), this technology has seen extensive use in various perspectives of animal reproduction practices. Color Doppler ultrasonography has been enacted for early detection of pregnancy status in buffaloes (Vecchio et al 2012 ; Lasheen et al 2018 ; Samir and Kandiel 2019 ; Samir et al 2019 ), cows (Pugliesi et al 2014 ), and small ruminants (Serin et al 2010 ; Elmetwally et al 2016a ).…”

Section: Introductionmentioning

confidence: 99%

Emotional temperaments in advanced pregnant goats and its relationship with the feto-maternal blood flow and placentome echotexture

Samir,

Swelum,

Farag

et al. 2024

Vet Res Commun

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The current study aimed to investigate the effect of xylazine sedation (non-sedated versus sedated conditions) and animal temperament on the fetal and maternal hemodynamics during the late stage of gestation in goats. In addition, it aimed to study the concentrations of cortisol and the echotexture of the placentome. Fourteen goats were assigned into two equal groups (n = 7, each) based on the animal’s emotional temperament (calm versus nervous groups). All goats were examined for assessment of the blood flow within the fetal aorta (FA), umbilical artery (UMA), and middle uterine artery (MUA) using color-pulsed Doppler ultrasonography. Goats were exposed to light sedation using the recommended dose of xylazine (0.05 mg/Kg Bw) intramuscularly. Goats in each group were reassessed for the studied parameters after sedation. Blood samples were drawn to determine the concentrations of cortisol. Placentome echotexture pixel intensity (PXI) was evaluated using computer image analysis software. Results revealed the significant impact of the xylazine sedation on the Doppler indices of the blood flow within the measured arteries (FA, UMA, and MUA), the PXI of placentome echotexture, and cortisol concentrations. The emotional temperament of goats had significant effects on the blood flow parameters of the MUA and UMA, concentrations of cortisol, and the PXI of the placentome. The interaction effect (sedation x temperament) was noticed in the measured parameters of the UMA blood flow, fetal heart rate, and cortisol concentrations. In conclusion, xylazine sedation and emotional temperaments induced alterations in the echotexture of the placentomes as well as the hemodynamic parameters of late-stage pregnant goats without affecting the pregnancy outcomes.

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“…To mitigate these effects, the use of external antioxidants is recommended to improve cellular antioxidant capacity and influence important biochemical pathways, including the activation of the Antioxidants 2024, 13, 597 2 of 34 nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This intervention aims to protect mammalian reproductive cells from oxidative damage and apoptosis [2,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A Narrative Review

Khan,

Huang

et al. 2024

Antioxidants

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Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses. It poses a significant threat to the physiological function of reproductive cells. Factors such as xenobiotics and heat can worsen this stress, leading to cellular damage and apoptosis, ultimately decreasing reproductive efficiency. The nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathway plays a crucial role in defending against oxidative stress and protecting reproductive cells via enhancing antioxidant responses. Dysregulation of Nrf2 signaling has been associated with infertility and suboptimal reproductive performance in mammals. Recent advancements in therapeutic interventions have underscored the critical role of Nrf2 in mitigating oxidative damage and restoring the functional integrity of reproductive cells. In this narrative review, we delineate the harmful effects of heat and xenobiotic-induced oxidative stress on reproductive cells and explain how Nrf2 signaling provides protection against these challenges. Recent studies have shown that activating the Nrf2 signaling pathway using various bioactive compounds can ameliorate heat stress and xenobiotic-induced oxidative distress and apoptosis in mammalian reproductive cells. By comprehensively analyzing the existing literature, we propose Nrf2 as a key therapeutic target for mitigating oxidative damage and apoptosis in reproductive cells caused by exposure to xenobiotic exposure and heat stress. Additionally, based on the synthesis of these findings, we discuss the potential of therapies focused on the Nrf2 signaling pathway to improve mammalian reproductive efficiency.

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Effect of pre-treatment of melatonin on superovulation response, circulatory hormones, and miRNAs in goats during environmental heat stress conditions

Cited by 3 publications

References 105 publications

Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats

Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats

Emotional temperaments in advanced pregnant goats and its relationship with the feto-maternal blood flow and placentome echotexture

Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A Narrative Review

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