Effect of Preconditioning With Triiodothyronine on Renal Ischemia/Reperfusion Injury and Poly(ADP-Ribose) Polymerase Expression in Rats

Ferreyra, C.; O’Valle, Francisco; Osorio, J.M.; Moreno, Juan Manuel; Rodríguez, Iliana Otero; Vargas, Félix; Osuna, Antonio

doi:10.1016/j.transproceed.2009.06.060

Cited by 14 publications

(11 citation statements)

References 6 publications

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“…This suggests that under conditions of demand ischemia, the ApoE−/−- mice had decreased acute stress response. Since the basal levels of PARP were increased in the ApoE mice, and demand ischemia subsequently reduced PAR activity, the reduced PAR activity could be due to preconditioning which has been described in other systems(28, 29). …”

Section: Resultsmentioning

confidence: 73%

Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE–/– mice

Crawford

Albadawi

Robaldo

et al. 2013

Journal of Surgical Research

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Introduction Studies were designed to determine whether the ApoE−/− phenotype modulates the local skeletal muscle and systemic inflammatory (plasma) responses to lower extremity demand ischemia. The ApoE−/− phenotype is an experimental model for atherosclerosis in humans. Methods Aged female ApoE −/− and C57BL6 mice underwent femoral artery ligation, then divided into sedentary and demand ischemia (exercise) groups on day 14. Baseline and post exercise limb perfusion and hind limb function were assessed. On day 14, animals in the demand ischemia group underwent daily treadmill exercise through day 28. Sedentary mice were not exercised. On day 28, plasma and skeletal muscle from ischemic limbs were harvested from sedentary and exercised mice. Muscle was assayed for angiogenic and pro-inflammatory proteins, markers of skeletal muscle regeneration, and evidence of skeletal muscle fiber maturation. Results Hind limb ischemia was similar in ApoE −/− and C57 mice prior to the onset of exercise. Under sedentary conditions, plasma VEGF, IL-6, but not KC or MIP-2 were higher in ApoE (P<0.0001). Following exercise, plasma levels of VEGF, KC and MIP-2, but not IL-6 were lower in ApoE (P<0.004). The cytokines KC and MIP-2 in muscle was greater in exercised ApoE−/− mice as compared to C57BL6 mice (p=0.01). Increased PAR activity, and mature muscle regeneration was associated with demand ischemia in the C57BL6 mice as compared to the ApoE −/− mice (p=0.01). Conclusion Demand limb ischemia in the ApoE−/− phenotype exacerbated the expression of select systemic cytokines in plasma and blunted indices of muscle regeneration.

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Section: Resultsmentioning

confidence: 73%

Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE–/– mice

Crawford

Albadawi

Robaldo

et al. 2013

Journal of Surgical Research

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“…Furthermore, T 3 induces microRNAs 30a and 29 having antiapoptotic and antifibrotic actions, respectively [65], an aspect that requires further investigation under IR conditions. Redox signaling by TH also operates in kidney PC against IR injury as it improves renal function by increasing inulin clearance [66] and diminishing serum creatinine and urea levels [67] and proteinuria [68].…”

Section: T H Y R O I D H O R M O N E -D E P E N D E N T Protection Ofmentioning

confidence: 99%

“…Redox-dependent mechanisms such as oxidative stress suppression [67][68][69] and HO-1 induction [67] (Figure 1) are accompanied by improvement in renal ATP levels [66] and anti-inflammatory responses [67]. Besides heart and kidney PC by THs, T 4 administration to rats significantly diminished brain injury caused by middle cerebral artery occlusion, which was associated with downregulation of the expression of the inflammatoryrelated pro-oxidant enzymes inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2), while restoring that of neurotrophins [70].…”

Section: T H Y R O I D H O R M O N E -D E P E N D E N T Protection Ofmentioning

confidence: 99%

Redox signaling associated with thyroid hormone action: perspectives in medical sciences

Videla¹

2016

Oxid Antioxid Med Sci

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Redox signaling, as a consequence of thyroid hormone (TH)-induced energy metabolism, triggers adaptive cellular changes to resume homeostasis. In the liver, this is associated with the activation of redox-sensitive transcription factors promoting cell protection and survival, including the upregulation of antioxidant, anti-apoptotic, antiinflammatory, and cell proliferation responses, with concomitant higher energy supply and detoxification potentials.

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“…This effect was mediated by a T3 transient oxidative stress, and thus, it was abrogated by the administration of antioxidant N-acetyl-cysteine [23]. Thyroxine was cytoprotective in toxic and ischemic injury in kidney [24, 26]. Thus, T3 administration 24 h prior to renal ischemia could precondition against ischemia-reperfusion (I/R) injury.…”

Section: Thyroid Hormone: the “Black Box Of Repair?”mentioning

confidence: 99%

“…This was evident by a marked decrease in I/R-induced proteinuria. T3 treatment also improved lipid peroxidation biomarkers and increased antioxidant enzymes [24]. In another study, T4 administration immediately or 24 h after ischemia resulted in higher Inulin clearance and preserved cellular integrity [26].…”

Section: Thyroid Hormone: the “Black Box Of Repair?”mentioning

confidence: 99%

Thyroid Hormone and Tissue Repair: New Tricks for an Old Hormone?

Mourouzis

Politi

Pantos

2013

Journal of Thyroid Research

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Although the role of thyroid hormone during embryonic development has long been recognized, its role later in adult life remains largely unknown. However, several lines of evidence show that thyroid hormone is crucial to the response to stress and to poststress recovery and repair. Along this line, TH administration in almost every tissue resulted in tissue repair after various injuries including ischemia, chemical insults, induction of inflammation, or exposure to radiation. This novel action may be of therapeutic relevance, and thyroid hormone may constitute a paradigm for pharmacologic-induced tissue repair/regeneration.

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Effect of Preconditioning With Triiodothyronine on Renal Ischemia/Reperfusion Injury and Poly(ADP-Ribose) Polymerase Expression in Rats

Cited by 14 publications

References 6 publications

Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE–/– mice

Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE–/– mice

Redox signaling associated with thyroid hormone action: perspectives in medical sciences

Thyroid Hormone and Tissue Repair: New Tricks for an Old Hormone?

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