[1] Two-and three-dimensional mechanical models simulating the seismic cycle along thrust faults are devoted to the active front of the Northern Apennines buried under the Plio-Pleistocene sediments of the eastern Po Plain. The models aim at understanding two peculiar characters of the stress field in the region: (1) analyses of borehole breakouts and other well data, integrated with seismological information and field evidence, show along-depth variations (from extensional to strike slip to compressional for increasing depth) of the stress style along the active Mirandola anticline and (2) seismic and borehole breakout data suggest strong lateral rotations of the stress axes along the frontal and lateral ramp portions of the Mirandola thrust fault. Modeling results allowed us to understand that the mechanical decoupling along faults strongly affects the stress distribution in their vicinity, under the form of strong rotations of the principal stress axes. As a consequence the slip (either fast or slow) along active blind thrust faults could drive to local stress fields very different from that associated with regional tectonics. This could explain, together with other processes (such as differential compaction), the along-depth variation of the stress field observed in the Mirandola region and the strong lateral rotations of the principal stress axes observed along the lateral ramp of the Mirandola thrust fault. Finally, the seismic activity along one of the thrust fault ramps along the Apennines front should not interfere with the state of stress along adjacent ramps.Citation: Carminati, E., and L. Vadacca (2010), Two-and three-dimensional numerical simulations of the stress field at the thrust front of the Northern Apennines, Italy,