2021
DOI: 10.1155/2021/6681491
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Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats

Abstract: Background. Although hypothyroidism during pregnancy may develop grave outcomes for both mothers and offspring, management of which is still a challenge due to the insufficient understanding of this disease. The close correlation between hypothyroidism and preeclampsia is well documented, suggesting that preeclampsia is a potential risk factor for the development of maternal hypothyroidism. However, the exact role of preeclampsia in gestational hypothyroidism is still obscure. Objective. In this study, we expl… Show more

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“…A counterargument for this is that there was no association of TSH or FT4 with gestational hypertension in our previous study, which is opposite to the current study. Future studies are required to investigate any potential disruption of thyroid function during preeclampsia following experimental studies that show disruption of transthyretin physiology and hepatic deiodinase activity ( 23 , 24 ). This may indicate that current results and previous findings on FT4 and TSH could be spurious due to reverse causation.…”
Section: Discussionmentioning
confidence: 99%
“…A counterargument for this is that there was no association of TSH or FT4 with gestational hypertension in our previous study, which is opposite to the current study. Future studies are required to investigate any potential disruption of thyroid function during preeclampsia following experimental studies that show disruption of transthyretin physiology and hepatic deiodinase activity ( 23 , 24 ). This may indicate that current results and previous findings on FT4 and TSH could be spurious due to reverse causation.…”
Section: Discussionmentioning
confidence: 99%