Effect of preemptive dexamethasone and etoricoxib on postoperative period following impacted third molar surgery - a randomized clinical trial

Abstract

Background The aim of this study was to compare the anti-inflammatory effects of dexamethasone and etoricoxib after third molar extraction. Material and Methods A prospective, randomized, controlled, split-mouth study was conducted. 19 volunteers were allocated randomly to receive 90mg etoricoxib 1 hour prior to the procedure or 4mg intramuscular dexamethasone immediately after anesthesia. Baseline measurements were obtained preoperatively, and subsequent assessments were made on immediate postoperative, at 72 hours and 7 days after surgery to measure postoperative facial swelling by use of linear measurements, interincisal mouth opening width and visual analog scale score for pain. The amount of analgesics consumed was recorded. Descriptive statistics and the independent-samples t-test were used to compare the two groups at P < 0.05. Results Dexamethasone was effective in the control roasted edema for measurements of the mandibular angle - wing of the nose and mandibular angle - labial commissure 72 hours after surgery. And for the measurement mandibular angle - mentum, in the time of 72 hours and 7 days. There was no statistically significant difference in relation to pain and trismus. Conclusions Considering significant results for some measures of the variable edema for the group that used intramuscular dexamethasone and the difference without statistical significance between groups for the other variables studied, we seem to reflect the intramuscular indication of the corticosteroid in a single dosage in relation to the use of etoricoxib as pre-emptive medication. Key words:Corticosteroids, COX-2 selective, third-molar surgery.

Pre-emptive analgesic efficacy of injected ketorolac in comparison to other agents for third molar surgical removal: a systematic review

“…Oral Etirocoxib [10,22], celecoxib [11], acetaminophen [11], dexamethasone [17,21,24,25,35,36,39], diclofenac [17,36], codeine [17], ketorolac [19,21,43], methylprednisolone [25,35], paracetamol [26,48], dexketoprofen [26], ibuprofen [39,47,48], tramadol [40], nimesulide [40], ketoprofen [44], diflunisal [46], lornaxicam [46], rofecoxib [47].…”

“…Intramuscular Dexamethasone [10], diclofenac [18,27], ketorolac [18,30], tramadol [19,30,42,45], ketoprofen [27], meloxicam [42], 3.…”

Comparing pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life: a prospective quasi-experimental study

“…Participants were eligible if all inclusion criteria were met: (1) age 18 years or older; (2) absence of systemic diseases with patients classified as ASA I according to American Society of Anesthesiologists (ASA) classification criteria; (3) abstinence from the use of analgesic, anti-inflammatory, and/or antipyretic drugs in the previous seven days; (4) absence of patient allergy to the molecule and/or excipients of the drugs used; (5) absence of infectious foci at the surgical site and/or absence of symptoms; and (6) mandibular third molars with complete clinical-radiographic indication of disodontiasis of the included or semi-included mandibular third molar intended for extraction [ 10 , 18 , 19 ]. Ineligibility for study participation was verified if participants met at least one of the following exclusion criteria: (1) pregnant or breastfeeding; (2) history of gastrointestinal ulcer or peptic ulcer events; (3) allergy to aspirin or other non-steroidal anti-inflammatory drugs; (4) systemic diseases affecting the kidneys, liver, blood, or central nervous system; (5) abuse of psychostimulant substances, analgesics, steroids, and/or non-steroidal anti-inflammatory drugs; and (6) use of contraceptives [ 10 , 18 , 19 ]. Patients were excluded if they did not complete the study or strictly adhere to the study protocol.…”

Complications following alveolar ridge augmentation procedures

“…Often related to the aforementioned complications is the development of postoperative edema and swelling, 20,21,23,30,41 although it is not necessarily associated with hematoma or petechiae development. Evidence originating solely from impacted third molar extraction studies indicates that it is possible to limit postoperative swelling with pre‐emptive use of prescription anti‐inflammatory medication 42,43 ; however, there are no pertinent studies in the RAP literature.…”