“…The PRISMA checklist result is reported in Table S4. Aghaie, 2014 [25] FAS (+) RASS (+) Ames, 2017 [26] NRS (+) Beaulieu-B, 2013 [27] − − − Serum cortisol (+) Blankfield, 1995 [28] Depression (−) Broscious, 1999 [29] NRS (−) Chan, 2007 [30] + + + UCLA (+) Chan, 2009 [31] + + + + Chiasson, 2013 [32] TVPS (−) Chlan, 1995 [33] − + + + − Mood states (+) Chlan, 1998 [34] − − STAI (+) Chlan, 2007 [35] + Biomarkers § (−) Chlan, 2013 [36] VAS (+) Urine cortisol (+) Ci gerci, 2016 [37] VAS (+) STAI (−) Conrad, 2007 [38] − Sedation level (+) Cooke, 2010 [39] NRS (−) FAS (−) Discomfort: NRS (−) Dijkstra, 2010 [40] − − − − Sedation level (+) Guilbaut, 2017 [41] NRS (+) Han, 2010 [42] + + + + − STAI (+) Hunter, 2010 [43] + + 98% less † Iblher, 2011 [44] − − − − Delirium: CAM (−) Jaber, 2007 [45] − − − − NRS (+) Jafari, 2012 [46] NRS (+) Korhan, 2011 [47] + + − + − Kyavar, 2016 [48] CPOT (+) Lee, 2017 [49] + − + STAI/VAS (+) Serum cortisol (+) Lee, 2005 [50] − − + + STAI (−) Mateu-C, 2019 [51] BPS (−) Sanjuan N, 2013 [52] NRS (−) STAI (+) Özer, 2013 [53] + VPIS (+) Phillips, 2007 [54] − − − Saadatmand, 2015 [55] VAS (+) Saadatmand, 2013 [56] + + FAS (+) RASS (+) Shultis, 2012 [57] VAS (−) Su, 2013 [58] + + Sleep quality (+) ‡ To, 2013 [59] − − − Ramsay scores (−) Voss, 2004 [60] VAS (+) Wong, 2001 [61] − STAI (+) Wu, 2008…”