Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture

Hüseyınoğlu, Ürfettin; Huseyinoglu, Nergiz; Hamurtekin, Emre; Aygün, Hayati; Sulu, Barlas

doi:10.1016/j.jocn.2011.02.029

Cited by 27 publications

(10 citation statements)

References 41 publications

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“…In this regard, it has been claimed in a number of studies that gabapentin and pregabalin can reduce PDPH via affecting this type of calcium channels. [8]…”

Section: Discussionmentioning

confidence: 99%

“…In the study by Huseyinoglu et al ., 5 days administration of pregabalin significantly lowered VAS scores after 2 nd day of treatment. [8] Furthermore in the case study of Zencirci, pregabalin was demonstrated to be able to significantly decrease PDPH in patients who had not responded to conventional treatments. [7] Beside studies which were mentioned above, very few studies have compared the efficacy of gabapentin and pregabalin in reducing PDPH.…”

Section: Discussionmentioning

confidence: 99%

“…[28] Gabapentin and pregabalin have been suggested in several studies to be efficient. Gabapentin is an antiepileptic drug and a structural analogue of gamma-Aminobutyric acid (GABA) but it does not act through GABA receptors.…”

Section: Introductionmentioning

confidence: 99%

“…Pregabalin, is also an antiepileptic agent and a ligand of the alpha2-delta type voltage-dependent calcium channels. [89] The aim of this study was to compare the effects of acetaminophen, gabapentin and pregabalin in controlling PDPH in patients who underwent surgery under spinal anesthesia.…”

Section: Introductionmentioning

confidence: 99%

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Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache

et al. 2014

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Introduction:Post-dural puncture headache (PDPH) is a common complication of lumbar puncture for any purpose. To avoid the need for invasive methods of treating PDPH such as blood patch, the search for novel pharmacological agents to manage PDPH continues. The aim of this study was to compare the effects of acetaminophen, gabapentin and pregabalin in controlling PDPH in patients who underwent surgery under spinal anesthesia.Materials and Methods:A total of 90 patients who underwent elective orthopedic surgery under spinal anesthesia and suffered from PDPH consequently were enrolled in this randomized trial. Patients were categorized randomly into three groups. Group A, B and C have received Acetaminophen, Gabapentin and Pregabalin (3 times a day for 3 days), respectively. The effect of medications on the severity of PDPH was evaluated and compared using visual analog scale (VAS).Results:The mean VAS score was significantly lower in pregabalin group compared with others 24, 48 and 72 h after the onset of headache (P = 0.001 for all of them) and lower in Gabapentin group compared with Acetaminophen group 24, 48 and 72 h after the onset of headache (P = 0.001 for all analyses). No adverse outcome was reported in groups.Conclusion:Pregabalin and gabapentin are both useful and safe in management of PDPH, but pregabalin is more effective in this regard.

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“…In this regard, it has been claimed in a number of studies that gabapentin and pregabalin can reduce PDPH via affecting this type of calcium channels. [8]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache

et al. 2014

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“…Cerebral vasodilators such as caffeine and the triptans are usually unsatisfactory, 23,24 and there is insufficient evidence that conventional analgesics are of benefit, although opioids arguably elevate mood and provide helpful sedation. Cosyntropin or repeat doses of intravenous hydrocortisone 25 and oral gabapentinoids 26,27 are the best supported and worth trying, but again require confirmatory evidence from larger trials.…”

mentioning

confidence: 99%

Iatrogenic headaches: giving everyone a sore head

Paech¹

2012

International Journal of Obstetric Anesthesia

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Drug therapy for treating post-dural puncture headache

Ona

Osorio

Cosp

2015

Cochrane Database of Systematic Reviews

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Background This is an updated version of the original Cochrane review published in Issue 8, 2011, on 'Drug therapy for treating post-dural puncture headache'. Post-dural puncture headache (PDPH) is the most common complication of lumbar puncture, an invasive procedure frequently performed in the emergency room. Numerous pharmaceutical drugs have been proposed to treat PDPH but there are still some uncertainties about their clinical e ectiveness. Objectives To assess the e ectiveness and safety of drugs for treating PDPH in adults and children. Search methods The searches included the Cochrane Central Register of Controlled Trials (

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Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture

Cited by 27 publications

References 41 publications

Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache

Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache

Iatrogenic headaches: giving everyone a sore head

Drug therapy for treating post-dural puncture headache

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