Effect of pregnancy and lactation on a benign phyllodes tumour

Ooi, Li Yin; Lim, Geok Hoon; Gudi, Mihir

doi:10.1136/bcr-2021-247340

Cited by 1 publication

(1 citation statement)

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“…In a recent case report that conducted serial ultrasound measurements of a benign phyllodes tumor during pregnancy and lactation, the largest growth was observed during early pregnancy and no obvious milk retention was noted upon removal. [ 6 ]. Meanwhile, Likhitmaskul et al reported the case of a 36-year-old woman who was diagnosed with a 20 cm-sized benign phyllodes tumor at 32 week gestation, whose internal cystic cavity contained about 300 mL of milky liquid when the surgical specimen was resected [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

A case of phyllodes tumor with rapid growth during pregnancy and lactation period: a case report

Tohyama,

Horimoto,

Ushiyama

et al. 2024

surg case rep

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Background The age of onset of the phyllodes tumor is generally in the late 40 s, and diagnosis and treatment during pregnancy and lactation are rare. We herein present a case of a phyllodes tumor that rapidly increased in size during the pregnancy and lactation period. Case presentation A 39-year-old woman was referred to our hospital with a mass in the right breast that increased in size during the pregnancy and lactation period. On ultrasound (5 week postpartum), a well-defined lobulated mass with internal septations and fluid retention was observed. Magnetic resonance imaging of the breast at 8 week postpartum revealed a 70-mm-sized smooth-margin mass with multilocular cystic components. Marked proliferation of stromal cells with high cell density was observed in a biopsy specimen taken at the previous hospital. We diagnosed the mass as a phyllodes tumor of borderline malignancy and excised it at 13 week postpartum. The excised tumor was 85 mm in diameter and its interior was filled with a milk-like substance. Histologically, there was only a mild increase in stromal cell density but fibrosis with associated degeneration was prominent. The final diagnosis was benign phyllodes tumor with degeneration. Conclusions We report a case of a phyllodes tumor that rapidly increased in size during pregnancy and the lactation period. The accumulation of a milk-like substance was thought to be responsible for the rapid growth of the tumor.

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Section: Discussionmentioning

confidence: 99%