In this study TC4/TC17 titanium alloy dissimilar joints were obtained via vacuum electron beam welding. The compressivebehavior of base metals and joint at different strain levels was studied, along with microstructural and fracture surface observations. The true stress-strain curves of base metals and joint at different strains demonstrated smooth and continuous plastic deformation characteristics. The compressive yield strength of the joint was basically equivalent to that of TC17 alloy, which was significantly higher than that of TC4 alloy. However, the compressive fracture strain of the joint was lower than that of base metals. Comparison of the microstructures of base metals and joint deformed at different strains, it revealed that the equiaxed α phase in TC4 alloy mainly underwent the deformation, while the TC17 alloy mainly relied on the rotation of lamellar grains to resist the deformation. In the dissimilar joint with a large microstructural gradient, the compressive deformation of several zones, including the weld zone, far heat-affected zone and the base metal, was also related to the rotation of finer grains.